1-ISOQUINOLIN-1-YL-ETHANONE
- CAS No.
- 58022-21-2
- Chemical Name:
- 1-ISOQUINOLIN-1-YL-ETHANONE
- Synonyms
- 1-(Isoquinolin-1-yl);1-acetylisoquinoline;1-ISOQUINOLIN-1-YL-ETHANONE;1-(1-Isoquinolinyl)ethanone;Ethanone, 1-(1-isoquinolinyl)-;1-(Isoquinolin-1-yl)ethan-1-one
- CBNumber:
- CB1770607
- Molecular Formula:
- C11H9NO
- Molecular Weight:
- 171.2
- MDL Number:
- MFCD08062665
- MOL File:
- 58022-21-2.mol
1-ISOQUINOLIN-1-YL-ETHANONE price More Price(20)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | I918550 | 1-(Isoquinolin-1-yl)ethanone | 58022-21-2 | 50mg | $90 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | CHM0069782 | ETHANONE, 1-(1-ISOQUINOLINYL)- 95.00% | 58022-21-2 | 1G | $1394.66 | 2021-12-16 | Buy |
| Crysdot | CD11100544 | 1-(Isoquinolin-1-yl)ethanone 95+% | 58022-21-2 | 10g | $1406 | 2021-12-16 | Buy |
| Alichem | 58022212 | 1-(Isoquinolin-1-yl)ethanone | 58022-21-2 | 10g | $1462.6 | 2021-12-16 | Buy |
| Ambeed | A221887 | 1-(Isoquinolin-1-yl)ethanone 97% | 58022-21-2 | 25g | $1652 | 2021-12-16 | Buy |
1-ISOQUINOLIN-1-YL-ETHANONE Chemical Properties,Uses,Production
Synthesis
1198-30-7
58022-21-2
General procedure for the synthesis of 1-acetylisoquinoline from 1-cyanoisoquinoline: An ether solution of methylmagnesium bromide (8.1 mL, 24.3 mmol) was dissolved in 16 mL of tetrahydrofuran under nitrogen protection in a pre-oven-dried 100 mL two-necked round-bottomed flask. The reaction system was cooled to 0 °C and 1-isoquinolinecarbonitrile (3.0 g, 19.5 mmol) was added after dilution with 8 mL of ether. The reaction mixture was heated to reflux for 1 h. Subsequently, the reaction was cooled to 0 °C and quenched with 20 mL of 6 M hydrochloric acid. The reaction solution was warmed to 50 °C and maintained for 2 h. After cooling, it was poured into 75 mL of 2 N sodium hydroxide solution. The mixture was extracted with ethyl acetate (3 x 80 mL), the organic phases were combined and dried over potassium carbonate. The dried organic phase was concentrated under vacuum to give the crude product as an amber colored oil. The crude product was purified by silica gel column chromatography (150 g, 230-400 mesh) with 10% acetone/hexane as eluent and 22 mL of fractions were collected. The fractions 16-26 were combined and concentrated to give 2.1 g of 1-acetylisoquinoline (62% yield). The product was analyzed by NMR hydrogen spectrum (CDCl3, TMS): δ 2.87 (s, 3H), 7.64-7.73 (m, 2H), 7.80 (d, J = 5.5 Hz, 1H), 7.83-7.88 (m, 1H), 8.58 (d, J = 5.5 Hz, 1H), 8.94-8.98 (m, 1H) ppm; NMR carbon spectrum ( CDCl3): δ 28.6, 124.6, 125.7, 126.9, 127.0, 129.1, 130.3, 137.0, 141.0, 152.8, 202.7 ppm confirmed. Thin layer chromatography (silica gel-60, F-254): Rf = 0.45 (acetone/hexane, 20%). IR spectrum (νmax, liquid film): 3054, 1694, 1582, 1358, 1239, 1133, 940, 833, 750 cm-1. Mass spectrum: [M/Z] (relative intensity): 171 (63). Elemental analysis: Calculated values (C11H9NO): C, 77.17; H, 5.30; N, 8.18. Measured values: C, 77.09; H, 5.33; N, 8.10.
References
[1] Patent: US6043248, 2000, A
1-ISOQUINOLIN-1-YL-ETHANONE Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
1-ISOQUINOLIN-1-YL-ETHANONE Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Accela ChemBio Inc. | +1-858-6993322 | info@accelachem.com | United States | 21193 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| Dayang Chem (Hangzhou) Co.,Ltd. | +86-0571-88938639 +8617705817739 | info@dycnchem.com | China | 52846 | 58 |
| Nanjing Hengbei Chemicals Co., Ltd. | +86-25-58393656 | sales@hengbeichem.cn | China | 6854 | 58 |
| PT CHEM GROUP LIMITED | +86-85511178; | peter68@ptchemgroup.com | China | 35425 | 58 |
| GIHI CHEMICALS CO.,LIMITED | +8618058761490 | info@gihichemicals.com | China | 49983 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131957 | 58 |
| NovoChemy Ltd. | 021-31261262/ 49 (0)17662837245 | sales@novochemy.com | Germany | 6328 | 58 |
| SynAsst Chemical. | 021-60343070 | China | 12740 | 55 | |
| Shanghai Sheepchem Co., Ltd. | +86 (21) 6715-7650 | sheepchem@163.com | China | 994 | 60 |
