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ChemicalBook >> CAS DataBase List >>Huperzine A

Huperzine A

CAS No.
120786-18-7
Chemical Name:
Huperzine A
Synonyms
SELAGINE;HUPERAZINE A;HUPERZINE A;[+/-]-SELAGINE;(+/-)-SELAGINE;(±)-Huperzine A;(+/-)-HuperzineA;(+/-)-HUPERZINE A;(+/-)-HUPERAZINE A;(±)-Huperzine A, >98%
CBNumber:
CB0308078
Molecular Formula:
C15H18N2O
Molecular Weight:
242.32
MDL Number:
MFCD00171439
MOL File:
120786-18-7.mol
MSDS File:
SDS
Last updated:2025-04-30 17:58:12

Huperzine A Properties

Boiling point 505.0±50.0 °C(Predicted)
Density 1.20±0.1 g/cm3(Predicted)
storage temp. 2-8°C
solubility DMSO : ≥ 50 mg/mL (206.34 mM)
pka 12.25±0.60(Predicted)
form solid
color White or off-white
InChI InChI=1S/C15H18N2O/c1-3-11-10-6-9(2)8-15(11,16)12-4-5-14(18)17-13(12)7-10/h3-6,10H,7-8,16H2,1-2H3,(H,17,18)/b11-3+
InChIKey ZRJBHWIHUMBLCN-QDEBKDIKSA-N
SMILES C12CC3/C(=C\C)/C(N)(C=1C=CC(=O)N2)CC(C)=C3
CAS DataBase Reference 120786-18-7
FDA UNII 0111871I23

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS06
Signal word  Danger
Hazard statements  H301+H311+H331-H315-H319-H335
Precautionary statements  P261-P280-P301+P310-P302+P352+P312-P304+P340+P311-P305+P351+P338
Hazard Codes  T
Risk Statements  23/24/25-36/37/38
Safety Statements  26-36/37/39-45
RIDADR  UN 1544 6.1/PG 2
WGK Germany  3
RTECS  PB9185700

Huperzine A price More Price(15)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich H5777 (±)-Huperzine A synthetic, ≥98% (TLC) 120786-18-7 1mg $269 2024-03-01 Buy
TRC H826003 (+/-)-HuperzineA 120786-18-7 5mg $65 2021-12-16 Buy
TRC H826003 (+/-)-HuperzineA 120786-18-7 10mg $110 2021-12-16 Buy
TRC H826003 (+/-)-HuperzineA 120786-18-7 25mg $200 2021-12-16 Buy
Biorbyt Ltd orb594012 Huperzine A 120786-18-7 20mg $238 2021-12-16 Buy
Product number Packaging Price Buy
H5777 1mg $269 Buy
H826003 5mg $65 Buy
H826003 10mg $110 Buy
H826003 25mg $200 Buy
orb594012 20mg $238 Buy

Huperzine A Chemical Properties,Uses,Production

Description

Huperzine A is an alkaloid extract derived from the Chinese club moss Huperzia serrata. It is an acetylcholinesterase inhibitor. This means it helps promote higher levels of acetylcholine in the brain. Higher levels of acetylcholine support ones ability to perform cognitive tasks such as learning new things, memorizing information, and focusing at the task at hand. Huperzine A is considered to be a nootropic supplement because it supports cognitive function. It is considered a focus and memory nootropic similar to alpha gpc, bacopa, phosphatidylcholine, cdp choline, sulbutiamine, and uridine. It is also considered a brain booster as it is used for brain health and support.
Huperzine A for many years has been widely used in traditional Chinese medicine to enhance memory and to treat fever and inflammation. In the United States it is commercially available as a food supplement, but has not been approved by the FDA as a treatment for AD or other cognition disorders.

Occurrence

The herbs of Lycopodium serratum.

Uses

Huperzine A is used for dementia in Alzheimer's disease and for muscle weakness in myasthenia gravis. In Alzheimer's disease, Huperzine A leads to significant improvements in memory and cognitive and behavioral function.

Application

(+/-)-Huperzine A is an NMDA antagonist. It has been used in anti-acetylcholinesterase bioautographic assay.

benefits

Huperzine A can help support learning and memory by protecting acetylcholine, a neurotransmitter that acts as a messenger molecule in the brain. Huperzine A may be used for both short-term "brain boost" needs, such as preparing for a test, as well as more long-term needs, such as reducing the mild memory loss associated with normal aging.
ACETYLCHOLINESTERASE INHIBITOR - Huperzine A acts as a reversible Acetylcholinesterase inhibitor meaning it supports levels of the neurotransmitter acetylcholine which plays a key role in cognitive function.
SUPPORTS COGNITIVE FUNCTION - Supports working memory, motivation, and problem solving ability.
SUPPORTS ENERGY AND STAMINA - Huperzine A supports mental energy, stamina, and sustained focus.

Biological Activity

Huperzine A is an effective acetylcholinesterase inhibitor and can cross the blood-brain barrier. Huperzine A is known to prevent cognitive defects, glutamate-induced nerve cell death.It is recognized for its use in the treatment of Alzheimer′s disease and organophosphate poisoning.

Side effects

When taken at recommended doses Huperzine A is well tolerated and presents few side effects. Rarely, side effects including nausea, diarrhea, and loss of appetite may occur. Adverse side effects are more likely when exceeding the recommended dosage.
Huperzine A is not recommended for people suffering from heart conditions, consult your physician before taking this product.

Mode of action

Huperzine A is a reversible acetycholinesterase inhibitor that can cross the blood-brain barrier. This constituent can inhibit the activity of acetycholinesterase in the brain for several hours, which allows for increased levels of acetylcholine in different areas of the brain. Because of its effects on acetylcholine, Huperzine A is considered a beneficial therapuetic agent in the treatment of memory impairment, myasthenia gravis, and dementia.
Herbs and Nutrients for the Mind A Guide to Natural Brain Enhancers By Chris D. Meletis, Jason E. Barker · 2004

Dosage forms

Huperzine A supplementation tends to be in the range of 50 - 200 mcg daily. Our tablets are 200 mcg each, but can be easily broken into halves or quarters for those wishing to take smaller doses.
Huperzine A has a long half-life (10-14 hours), so cycling this product is often recommended. We recommend taking it no more than 2-3 times per week, or if using it daily we recommend taking a 1 week break for every 2 weeks of use.

120786-17-6
120786-18-7
Synthesis of Huperzine A from 5,9-Methanocycloocta[b]pyridine-5(6H)-carboxylic acid, 11-ethylidene-9,10-dihydro-2-methoxy-7-methyl-, methyl ester, (11E)-
Global( 204)Suppliers
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Related articles

View Lastest Price from Huperzine A manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Huperzine A pictures 2025-05-17 Huperzine A
120786-18-7
 US $60.00 / G 1G 98% 99% 10000 Changsha Staherb Natural Ingredients Co., Ltd.
Huperzine A pictures 2025-05-17 Huperzine A
120786-18-7
 US $0.00-0.00 / kg 1kg 1-98% 1000kg Changsha Staherb Natural Ingredients Co., Ltd.
Huperzine A pictures 2025-05-16 Huperzine A
120786-18-7
 US $0.00 / kg 1kg 0.99 1000kg Shaanxi Xianhe Biotech Co., Ltd
  • Huperzine A pictures
  • Huperzine A
    120786-18-7
  • US $60.00 / G
  • 98% 99%
  • Changsha Staherb Natural Ingredients Co., Ltd.
  • Huperzine A pictures
  • Huperzine A
    120786-18-7
  • US $0.00-0.00 / kg
  • 1-98%
  • Changsha Staherb Natural Ingredients Co., Ltd.
  • Huperzine A pictures
  • Huperzine A
    120786-18-7
  • US $0.00 / kg
  • 0.99
  • Shaanxi Xianhe Biotech Co., Ltd

Huperzine A Spectrum

(+/-)-SELAGINE [+/-]-SELAGINE 1-Amino-13-ethylidene-11-methyl-6-aza-tricyclo[7.3.1.02,7]trideca-2(7),3,10-trien-5-one (+/-)-HUPERAZINE A (+/-)-HUPERZINE A HUPERZINE A ((plusmn))-Huperzine A (11E)-5-Amino-11-ethylidene-5,6,9,10-tetrahydro-7-methyl-5,9-methanocycloocta[b]pyridin-2(1H)-one (±)-Huperzine A, >98% Huperzia Serrata Extract (Standard) 5,9-Methanocycloocta[b]pyridin-2(1H)-one, 5-amino-11-ethylidene-5,6,9,10-tetrahydro-7-methyl-, (11E)- (+/-)-HuperzineA Huperzine A USP/EP/BP (±)-Huperzine A solution HUPERAZINE A SELAGINE (E)-5-amino-11-ethylidene-7-methyl-5,6,9,10-tetrahydro-5,9-methanocycloocta[b]pyridin-2(1H)-one Cholinesterase (ChE),inhibit,Inhibitor,(±)-Huperzine A,(±) Huperzine A,(±)Huperzine A (±)-Huperzine A, 10 mM in DMSO (±)-Huperzine A 120786-18-7 Cholinesterase, acetyl Enzyme Inhibitors Enzyme Inhibitors by Enzyme Enzymes, Inhibitors, and Substrates A to C Biochemicals and Reagents BioChemical Herb extract Natural Plant Extract Acetylcholine receptor