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ChemicalBook >> CAS DataBase List >>ST1481

ST1481

CAS No.
292618-32-7
Chemical Name:
ST1481
Synonyms
ST1481;Lbq707;STI481;CPT 184;GIMATECAN;Unii-7kks9R192f;ST1481: GIMATECAN;LBQ707; ST1481; CPT 184;ST1481 ST-1481 Gimatecan;Gimatecan, 10 mM in DMSO
CBNumber:
CB01011641
Molecular Formula:
C25H25N3O5
Molecular Weight:
447.488
MDL Number:
MFCD06795143
MOL File:
292618-32-7.mol
Last updated:2025-05-13 12:04:06

ST1481 Properties

Boiling point 780.6±70.0 °C(Predicted)
Density 1.37±0.1 g/cm3(Predicted)
storage temp. Store at -20°C
pka 11.20±0.20(Predicted)
form Solid
color Light yellow to yellow
NCI Dictionary of Cancer Terms gimatecan; ST1481
FDA UNII 7KKS9R192F
NCI Drug Dictionary gimatecan

ST1481 price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
ChemScene CS-0006524 Gimatecan 99.20% 292618-32-7 5mg $350 2021-12-16 Buy
American Custom Chemicals Corporation API0002825 GIMATECAN 95.00% 292618-32-7 1G $1091.48 2021-12-16 Buy
Product number Packaging Price Buy
CS-0006524 5mg $350 Buy
API0002825 1G $1091.48 Buy

ST1481 Chemical Properties,Uses,Production

Uses

Gimatecan (ST1481) is a potent topoisomerase I inhibitor. Gimatecan is an orally bioavailable camptothecin analogue with antitumor activity[1].

Biological Activity

Gimatecan (ST1481) is a potent topoisomerase I inhibitor. It is an orally active camptothecin analog with antineoplastic activity.

in vivo

Gimatecan (2 mg/kg; treatment per os, every fourth day for four times) is effective for inhibiting tumor growth.

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target

Animal Model: Athymic Swiss nude mice bearing HT1376 model
Dosage: 2 mg/kg
Administration: Treatment per os, every fourth day for four times
Result: Caused a marked tumor growth inhibition during treatment.

Topoisomerase I

IC 50

Topoisomerase I

References

[1] Paola Ulivi, et al. Cellular Basis of Antiproliferative and Antitumor Activity of the Novel Camptothecin Derivative, Gimatecan, in Bladder Carcinoma Models. Neoplasia. 2005 Feb;7(2):152-61. DOI:10.1593/neo.04397

ST1481 Preparation Products And Raw materials

Raw materials

Preparation Products

Global( 48)Suppliers
Supplier Tel Email Country ProdList Advantage
Shanghai Zheyan Biotech Co., Ltd. 		18017610038 zheyansh@163.com CHINA 3619 58
Hubei Jusheng Technology Co.,Ltd. 		18871490254 linda@hubeijusheng.com CHINA 28172 58
Shochem(Shanghai) Co.,Ltd 		86-21-50800795 info@shochem.com CHINA 288 58
CONIER CHEM AND PHARMA LIMITED 		+8618523575427 sales@conier.com China 49732 58
career henan chemical co 		+86-0371-86658258 +8613203830695 factory@coreychem.com China 29807 58
TargetMol Chemicals Inc. 		+17819995354 marketing@targetmol.com United States 32281 58
Zhejiang J&C Biological Technology Co.,Limited 		+1-2135480471 +1-2135480471 sales@sarms4muscle.com China 10473 58
Hangzhou MolCore BioPharmatech Co.,Ltd. 		+86-057181025280; +8617767106207 sales@molcore.com China 49734 58
Zhengzhou Anbu Chem Co.,Ltd 		+86-0371-88006763; +8615988602810 sales@anbuchem.com China 2998 58
Aladdin Scientific 		tp@aladdinsci.com United States 52924 58

View Lastest Price from ST1481 manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Gimatecan pictures 2025-05-13 Gimatecan
292618-32-7
 US $116.00-478.00 / mg 98.47% 10g TargetMol Chemicals Inc.
ST1481 pictures 2020-01-09 ST1481
292618-32-7
 US $1.00 / g 1g 99% 200kg Career Henan Chemical Co
  • Gimatecan pictures
  • Gimatecan
    292618-32-7
  • US $116.00-478.00 / mg
  • 98.47%
  • TargetMol Chemicals Inc.
  • ST1481 pictures
  • ST1481
    292618-32-7
  • US $1.00 / g
  • 99%
  • Career Henan Chemical Co

ST1481 Spectrum

GIMATECAN ST1481 ST1481: GIMATECAN (4S)-11-((E)-((1,1-Dimethylethoxy)imino)methyl)-4-ethyl-4-hydroxy-1,12-dihydro-14H-pyrano(3',4':6,7)indolizino(1,2-b)quinoline-3,14(4H)-dione 1H-Pyrano(3',4':6,7)indolizino(1,2-B)quinoline-11-carboxaldehyde, 4-ethyl-3,4,12,14-tetrahydro-4-hydroxy-3,14-dioxo-, 11-(o-(1,1-dimethylethyl)oxime), (C(E),4S)- 7-T-Butoxyiminomethylcamptothecin Lbq707 Unii-7kks9R192f CPT 184 LBQ707; ST1481; CPT 184 7-[(E)-tert-butyloxyiminomethyl]-camptothecin STI481 ST1481 ST-1481 Gimatecan (S,E)-4-Ethyl-4-hydroxy-3,14-dioxo-3,4,12,14-tetrahydro-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-11-carbaldehyde O-(tert-butyl) oxime Gimatecan, 10 mM in DMSO (S,E)-4-Ethyl-4-hydroxy-3,14-dioxo-3,4,12,14-tetrahydro-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-11-carbaldehyde O-(tert-butyl) oxime 292618-32-7