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Sb-742457

Sb-742457 Struktur
607742-69-8
CAS-Nr.
607742-69-8
Englisch Name:
Sb-742457
Synonyma:
CS-579;RVT-101;CS-2723;Sb-742457;Sb 742457;Gsk 742457;SB742457 ，S2894;SB-742457(RVT-101);Sb-742457 USP/EP/BP;SB 742457/GSK 742457
CBNumber:
CB92495263
Summenformel:
C19H19N3O2S
Molgewicht:
353.44
MOL-Datei:
607742-69-8.mol

Sb-742457 Eigenschaften

Siedepunkt:
608.3±45.0 °C(Predicted)
Dichte
1.292
storage temp. 
Store at -20°C
L?slichkeit
insoluble in H2O; ≥17.65 mg/mL in DMSO; ≥2.13 mg/mL in EtOH with gentle warming and ultrasonic
pka
8?+-.0.10(Predicted)
Aggregatzustand
solid
Farbe
Light yellow to yellow
InChI
InChI=1S/C19H19N3O2S/c23-25(24,16-6-2-1-3-7-16)17-13-15-5-4-8-18(19(15)21-14-17)22-11-9-20-10-12-22/h1-8,13-14,20H,9-12H2
InChIKey
JJZFWROHYSMCMU-UHFFFAOYSA-N
SMILES
N1C2C(=CC=CC=2N2CCNCC2)C=C(S(C2=CC=CC=C2)(=O)=O)C=1
Sicherheit
  • Risiko- und Sicherheitserkl?rung
  • Gefahreninformationscode (GHS)
Bildanzeige (GHS) GHS hazard pictograms
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H302 Gesundheitssch?dlich bei Verschlucken. Akute Toxizit?t oral Kategorie 4 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P270, P301+P312, P330, P501
H315 Verursacht Hautreizungen. Hautreizung Kategorie 2 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P280, P302+P352, P321,P332+P313, P362
H319 Verursacht schwere Augenreizung. Schwere Augenreizung Kategorie 2 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P280, P305+P351+P338,P337+P313P
H335 Kann die Atemwege reizen. Spezifische Zielorgan-Toxizit?t (einmalige Exposition) Kategorie 3 (Atemwegsreizung) Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" />
Sicherheit
P261 Einatmen von Staub vermeiden.
P305+P351+P338 BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen.

Sb-742457 Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

SB-742457 is an orally bioavailable antagonist of the serotonin (5-HT) receptor subtype 5-HT6 (Ki = 1.4 nM). SB-742457 (1 μM) also binds to 5-HT1B, 5-HT2A, 5-HT2B, and 5-HT2C receptors with high affinity. SB-742457 reduces 5-HT6 activation of Gs-mediated cAMP production in a concentration-dependent manner with an EC50 value of 21 nM in NG108-15 neuroblastoma cells. In vivo, SB-742457 (1.5 mg/kg, p.o.) reverses deficits in novel object recognition induced by scopolamine in rats. It also reverses age-induced impairments in spatial memory acquisition and retention in rats in the Morris water maze. SB-742457 (3.0 mg/kg, i.p.) reduces the number of licking bouts by 24% compared with control in rats trained to lick a glucose solution, indicating a role in satiety and obesity management.

Verwenden

SB 742457 is a selective 5-HT6 receptor antagonist which is known to be involved in improving cognitive function.

Sb-742457 Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Piperazin 607743-09-9 8-fluoro-3-(phenylsulfonyl)- Quinoline 1,4-Dioxan Natrium-2-methylpropan-2-olat

Downstream Produkte

Sb-742457 Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 147)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795
ivan@atkchemical.com China 33024 60
career henan chemical co 		+86-0371-86658258 +8613203830695
 sales@coreychem.com China 29855 58
BOC Sciences 		+1-631-485-4226
inquiry@bocsci.com United States 19552 58
TargetMol Chemicals Inc. 		+1-781-999-5354; +17819995354
 marketing@targetmol.com United States 32376 58
Dideu Industries Group Limited 		+86-29-89586680 +86-15129568250
 1026@dideu.com China 22162 58
Hefei Hirisun Pharmatech Co., Ltd 		+8615056975894
 shawn@hirisunpharm.com CHINA 9911 58
Zhejiang J&C Biological Technology Co.,Limited 		+1-2135480471
sales@sarms4muscle.com China 10473 58
InvivoChem 		+1-708-310-1919 +1-13798911105
 sales@invivochem.cn United States 6391 58
Nantong HI-FUTURE Biology Co., Ltd. 		+undefined18051384581
 sales@chemhifuture.com China 3135 58
ShenZhen Trendseen Biological Technology Co.,Ltd. 		13417589054
 trendseenbio@gmail.com China 11681 58

607742-69-8()Verwandte Suche:

  • Gsk 742457
  • Sb 742457
  • Sb-742457
  • 3-Phenylsulfonyl-8-(piperazin-1-yl)quinoline
  • SB 742457/GSK 742457
  • Quinoline, 3-(phenylsulfonyl)-8-(1-piperazinyl)-
  • SB742457:Intepirdine
  • Intepirdine(SB742457)
  • 3-(BENZENESULFONYL)-8-(PIPERAZIN-1-YL)QUINOLINE
  • SB 742457;RVT 101;SB742457;RVT101
  • CS-579
  • SB-742457(RVT-101)
  • RVT-101
  • CS-2723
  • RVT101. intepirdine.
  • SB742457; SB 742457; SB-742457; RVT-101; RVT 101; RVT101. INTEPIRDINE.
  • Sb-742457 USP/EP/BP
  • Intepirdine (SB-742457, RVT-101）
  • Intepirdine HCl (SB-742457
  • SB 742457/GSK 742457/SB742457
  • SB742457 (Intepirdine), 5-HT6 antagonist
  • Intepirdine, 10 mM in DMSO
  • SB742457 ，S2894
  • 607742-69-8
  • Inhibitors
  • API
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