Bilirubin
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- CAS-Nr.
- 635-65-4
- Bezeichnung:
- Bilirubin
- Englisch Name:
- Bilirubin
- Synonyma:
- Cholerythrin;BILIRUBIN MIXED ISOMERS;Biliyubin;Bilibubin;filirubin;BILIRUBIN;hemetoidin;HEMATOIDIN;1,19-dioxo-;BilirubinGr
- CBNumber:
- CB8693422
- Summenformel:
- C33H36N4O6
- Molgewicht:
- 584.66
- MOL-Datei:
- 635-65-4.mol
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Bilirubin Eigenschaften
- Schmelzpunkt:
- 192 °C
- Siedepunkt:
- 641.7°C (rough estimate)
- Dichte
- 1.2163 (rough estimate)
- Brechungsindex
- 1.6000 (estimate)
- storage temp.
- -20°C
- L?slichkeit
- aqueous acid: soluble
- Aggregatzustand
- powder
- pka
- 4.62±0.10(Predicted)
- Farbe
- orange
- Wasserl?slichkeit
- practically insoluble
- Sensitive
- Light Sensitive
- Merck
- 14,1218
- BRN
- 74376
- Stabilit?t:
- Stable. Refrigerate.
- EPA chemische Informationen
- Bilirubin (635-65-4)
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| Bildanzeige (GHS) |
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| Alarmwort |
Warnung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H302 |
Gesundheitssch?dlich bei Verschlucken. |
Akute Toxizit?t oral |
Kategorie 4 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P270, P301+P312, P330, P501 |
| H315 |
Verursacht Hautreizungen. |
Hautreizung |
Kategorie 2 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P280, P302+P352, P321,P332+P313, P362 |
| H319 |
Verursacht schwere Augenreizung. |
Schwere Augenreizung |
Kategorie 2 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P280, P305+P351+P338,P337+P313P |
| H335 |
Kann die Atemwege reizen. |
Spezifische Zielorgan-Toxizit?t (einmalige Exposition) |
Kategorie 3 (Atemwegsreizung) |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
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| Sicherheit |
| P261 |
Einatmen von Staub vermeiden. |
| P305+P351+P338 |
BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen. |
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Bilirubin Chemische Eigenschaften,Einsatz,Produktion Methoden
R-S?tze Betriebsanweisung:
R62:Kann m?glicherweise die Fortpflanzungsf?higkeit beeintr?chtigen.
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
R20/21/22:Gesundheitssch?dlich beim Einatmen,Verschlucken und Berührung mit der Haut.
S-S?tze Betriebsanweisung:
S22:Staub nicht einatmen.
S24/25:Berührung mit den Augen und der Haut vermeiden.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
Beschreibung
Bilirubin is a yellow breakdown product of heme catabolism, formed when heme is cleaved by heme oxygenase. This reaction produces carbon monoxide and biliverdin, which is rapidly reduced to bilirubin by biliverdin reductase. Bilirubin has key roles as a free radical scavenger with antioxidant and anti-inflammatory actions. Free and albumin-bound bilirubin can also scavenge nitric oxide (NO) and NO-related species. Unconjugated bilirubin is highly water-insoluble and must be conjugated with glucuronides to become water soluble and subsequently excreted by the liver and kidney.
Chemische Eigenschaften
Light Orange to Deep Redish-Brown Crystalline Solid
Verwenden
Bilirubin is widely utilized to monitor the liver function and their disease, such as hepatitis or cirrhosis; or the effects of medicines which are damage the liver. It acts as a pigment in certain algae to capture light energy. Its double bonds are isomerizes in the presence of light, which is employed in phototherapy of jaundiced newborns babies. It is used to detect the blocking in bile ducts.
Definition
Red coloring matter of bile. Also occurs in blood serum as decomposition product of hemoglobin.
Allgemeine Beschreibung
Bilirubin, a heme catabolism end-product is produced by the reduction of its metabolic precursor biliverdin by the action of enzyme biliverdin reductase.
l?uterung methode
An acyclic tetrapyrrole bile pigment with impurities which can be eliminated by successive Soxhlet extraction with diethyl ether and MeOH. It crystallises from CHCl3 as deep red-brown rhombs, plates or orange-red prisms from chlorobenzene (m 330o dec) and is dried to constant weight at 80o under vacuum. [Gray et al. J Chem Soc 2264, 2276 1961, Beilstein 26 III/IV 3268.]
Bilirubin Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
3-α,6-α-Dihydroxy-5-β-cholan-24-sure
Atificial Cow-bezoar
3,17-Divinyl-1,10,19,22,23,24-hexahydro-2,7,13,18-tetramethyl-1,19-dioxo-21H-biline-8,12-dipropionic acid
Bilirubin Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 607)Lieferanten
635-65-4(Bilirubin)Verwandte Suche:
- 1，10，19，22，23，24-hexahydro-2，7，13，17-tetramethyl-1，19-dioxo-3，18-divinylbilidiene-8，12-dipropionic acid
- (Z,Z)-Bilirubin
- Biline-8,12-dipropionic acid, 1,10,19,22,23,24-hexahydro-2,7,13,17-tetramethyl-1,19-dioxo-3,18-divinyl-
- Bilirubin,99%
- Bilirubin, synthesis grade
- Bilibubin
- Biliyubin
- Bilirubin, 99% 1GR
- Bilirubin, 99% 500MG
- 12-dipropanoicacid,2,17-diethenyl-1,10,19,22,23,24-hexahydro-3,7,13,18-tetramethyl-1,19-dioxo-21H-Biline-8
- 18-divinyl-19-dioxo-3
- 21h-biline-8,12-dipropanoicacid,2,17-diethenyl-1,10,19,22,23,24-hexahydro-3,7
- bilirubinix-alpha
- 1,10,19,22,23,24-hexahydro-3,7,13,18-tetramethyl-
- 1,19-dioxo-
- 21H-Biline-8,12-dipropanoicacid,2,17-diethenyl-
- BILIRUBIN extrapure AR
- ,13,18-tetramethyl-1,19-dioxo-
- 1,10,19,22,23,24-hexahydro-2,7,13,17-tetramethyl-biline-12-dipropionicacid
- hemetoidin
- principalbilepigment
- BILIRUBIN CALIBRATOR, TOTAL & DIRECT
- BILIRUBIN CONTROL, TOTAL AND DIRECT*ELEVATED
- BILIRUBIN LIN-TROL TOTAL & DIRECT
- BILIRUBIN STANDARD
- BILIRUBIN CONTROL, TOTAL AND DIRECT*NORMAL
- BILIRUBIN LIN-TROL PREDILUTED SET
- BILIRUBIN: 21H-BILINE-8,12-DIPROPANOICACID,2,17-DIETHENYL-1,10,19,22,23,24-HEXAHYDRO-3,7,13,18-TETRAMETHYL-1,19-DIOXO-,
- D-BiotinForBiochemistry(VitaminH)
- BilirubinGr
- Bilirubin,97%
- 2,17-Diethenyl-1,10,19,22,23,24-hexahydro-3,7,13,18-tetrametyl-1,19-dioxo-21H-biline-8,12-dipropanoic Acid
- Bilirubin IXa
- 21H-Biline-8,12-dipropanoic acid, 2,17-diethenyl-1,10,19,22,23,24-hexahydro-3,7,13,18-tetramethyl-1,19-dioxo-
- 3-[2-[[3-(2-carboxyethyl)-5-[(Z)-(3-ethenyl-4-methyl-5-oxo-pyrrol-2-ylidene)methyl]-4-methyl-1H-pyrrol-2-yl]methyl]-5-[(Z)-(4-ethenyl-3-methyl-5-oxo-pyrrol-2-ylidene)methyl]-4-methyl-1H-pyrrol-3-yl]propanoic acid
- filirubin
- 12-dipropanoic acid, 2,17-diethenyl-1,10,19,22,23,24-hexahydro-3,7,13,18-tetramethyl-1,19-dioxo-21H-Biline-8
- BILIRUBIN REAGENT-GRADE
- Bilirubin from Porcine
- 3-{2-({3-(2-Carboxyethyl)-4-methyl-5-[(Z)-(3-methyl-5-oxo-4-vinyl-1,5-dihydro-2H-pyrrol-2-ylid
- Obeticholic Acid2
- HEMATOIDIN
- BILIRUBIN (EX PIG)
- BILIRUBIN
- BILIRUBIN (ALPHA)
- 21H-BILINE-8,12-DIPROPANOIC ACID,2,17-DIETHENYL-1,10,19,22,23,24-HEXAHYDRO-3,7,13,18-TETRAMETHYL-1,19-DIOXO-
- 2,17-Diethenyl-1,10,19,22,23,24-hexahydro-3,7,13,18-tetramethyl-1,19-dioxo-21H-biline-8,12-dipropanoic acid
- Bilirubin - CAS 635-65-4 - Calbiochem
- Indirect bilirubin
- Bilirubin USP/EP/BP
- 3-(2-((3-(2-Carboxyethyl)-4-methyl-5-((Z)-(3-methyl-5-oxo-4-vinyl-1H-pyrrol-2(5H)-ylidene)methyl)-1H-pyrrol-2-yl)methyl)-4-methyl-5-((Z)-(4-methyl-5-oxo-3-vinyl-1H-pyrrol-2(5H)-ylidene)methyl)-1H-pyrrol-3-yl)propanoic acid
- Bilirubin, GR 99%+
- 3-[2-[[3-(2-carboxyethyl)-5-[(3-ethenyl-4-methyl-5-oxo-2-pyrrolylidene)methyl]-4-methyl-3H-pyrrol-2-yl]methyl]-5-[(4-ethenyl-3-methyl-5-oxo-2-pyrrolylidene)methyl]-4-methyl-3H-pyrrol-3-yl]propanoic ac
- Cholerythrin
- BILIRUBIN MIXED ISOMERS
- bilirubin?powder
- 3- (2- (3- (2-carboxyethyl) -4-methyl-5- ((Z) - (3-methyl-5-oxy-4-vinyl-1H-pyrrole-2 (5H) - subunit) methyl) -1H-pyrrole-2-yl) methyl) -4-methyl-5- (Z) - (4-methyl-5-oxy-3-vinyl-1H-pyrrole-2 (5H) - subunit) methyl) -1H-pyrrole-3-yl) propionic acid
- Bilirubin Impurity
