Acetohydrazid Chemische Eigenschaften,Einsatz,Produktion Methoden
R-S?tze Betriebsanweisung:
R22:Gesundheitssch?dlich beim Verschlucken.
R36/38:Reizt die Augen und die Haut.
S-S?tze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Chemische Eigenschaften
White moist crystals and chunks
Definition
ChEBI: A carbohydrazide that is hydrazine in which one of the hydrogens is replaced by an acetyl group.
Sicherheitsprofil
Poison by ingestion, subcutaneous, and intraperitoneal routes. Mutation data reported. Exposure can cause hemolysis and liver damage. See also PHENYLHYDRAZINE. When heated to decomposition it emits toxic fumes of NOX,.
Synthese
A kind of preparation method of acethydrazide include the following steps: Under nitrogen protection, by acetic
acid, hydrazine hydrate
It is put into catalyst in the reaction kettle with rectifying column,
opens stirring, be heated to reflux, after steam enters rectifying
column,
Vapor are produced in tower top temperature for 98 DEG C~100 DEG C, when
reaction 4~6 is small at a reflux temperature, when rectifying tower
top frozen-free current
Reaction terminates after going out, and continues heating distillation,
and the acetic acid and hydrazine hydrate of reaction are had neither
part nor lot in 100 DEG C~120 DEG C extraction of tower top temperature,
After acetic acid and hydrazine hydrate are all steamed, liquid in
kettle is poured out into filtering while hot, filtrate is through
crystallisation by cooling, pure water, very
Acethydrazide finished product is obtained after sky is dry.
l?uterung methode
Acetic hydrazide crystallises as needles from EtOH. It reduces NH3/AgNO3. [Beilstein 2 H 191, 2 IV 435.]
Einzelnachweise
[1] S. Nzikayel, A. Ec, Akpan Ij. “Synthesis, FTIR and Electronic Spectra Studies of Metal (II) Complexes of Acethydrazide Derivative.” Medicinal Chemistry 8 1 (2018): 26–28.
[2] S. Pakdehi, A. S. Moghaddam, M. Sohrabi. “Liquid phase hydrogenation of acethydrazone to N’-methyl acethydrazide over Pd/γ-Al2O3 catalyst.” Brazilian Journal of Chemical Engineering 27 1 (2010): 145–152.
Acetohydrazid Upstream-Materialien And Downstream Produkte
Upstream-Materialien
2-Butoxyethylmethacrylat
Acetamide,N-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)-
NSC45006
2-butanone (1-methylpropylidene)hydrazone
Hydrazinecarboxylic acid, 2-acetyl-, 1,1-dimethylethyl ester (9CI)
2,2'-Ethylendithiodiethanol
1-Ethoxyethylidenammoniumchlorid
1,3-Diphenylpropan-1,3-dion
1-Phenylbutan-1,3-dion
Acetamid
Downstream Produkte
5-Methyl-1,3,4-thiadiazol-2(3H)-thion
5-Methyl-1,3,4-oxadiazol-2(3H)-one
FlubroMazolaM
5-Methyl-1,3,4-thiadiazol-2-ylamin
Ethyl 5-Methyl-1,3,4-thiadiazole-2-carboxylate
Methylammoniumnitrat
5-METHYL-1,3,4-OXADIAZOL-2-YLAMINE
(R)-(-)-tert-Butyl 2-(4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetate
