Olodaterol Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

In 2013, olodaterol (also known BI-1744 CL) was approved for the treatment of chronic obstructive pulmonary disease (COPD) in Russia (March), Canada (June), and the EuropeanUnion (October). Olodaterol is delivered via the Respimat? Soft Mist? inhaler. Olodaterol was discovered from an effort to identify a β2-adrenergic receptor agonist that could be given once daily and with a superior safety profile over known β2- adrenergic receptor agonists. Olodaterol is a potent β2 agonist (EC₅₀=0.1 nM, intrinsic activity=88%) and is highly selective for the β2 receptor over β1 and β3 receptors. In preclinical models in guinea pigs and dogs, olodaterol had a rapid onset of action and provided bronchoprotection over 24 h. Mechanistic studies indicated that olodaterol forms a highly stable complex with the β2-adrenergic receptor, with a dissociation half-life of 17.8 h. The synthesis of olodaterol proceeds through an (R)-styrene epoxide that is prepared via enantioselective reduction of an α-chloroketone intermediate. Ring opening of the epoxide with 1-(4- methoxyphenyl)-2-methylpropan-2-amine provides olodaterol.

Definition

ChEBI: A member of the class of benzoxazine that is 6-hydroxy-1,4-benzoxazin-3-one in which the hydrogen at position 4 is replaced by a (1R)-1-hydroxy-2-{[1-(4-methoxyphenyl)-2-methylpropan-2-yl]amino}ethyl group. Used (as its hydrochloride salt) for long-term treatment of airflow obstruction in patients with chronic obstructive pulmonary disease including chronic bronchitis and/or emphysema.

Olodaterol Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

Olodaterol Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Firmenname	Telefon	E-Mail	Land	Produktkatalog	Edge Rate
Hebei Yanxi Chemical Co., Ltd.	+8618531123677	faithe@yan-xi.com	China	5853	58
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	33024	60
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29855	58
BOC Sciences	+1-631-485-4226	inquiry@bocsci.com	United States	19552	58
Hebei Miaobian Biotechnology Co., Ltd	+8617733850068		CHINA	967	58
Baoji Guokang Bio-Technology Co., Ltd.	0917-3909592 13892490616	gksales1@gk-bio.com	China	9257	58
changzhou huayang technology co., ltd	+8615250961469	2571773637@qq.com	China	9647	58
InvivoChem	+1-708-310-1919 +1-13798911105	sales@invivochem.cn	United States	6391	58
Hefei TNJ Chemical Industry Co.,Ltd.	+86-0551-65418684 +8618949823763	sales@tnjchem.com	China	25356	58
Hebei Yinsheng Technology Co., Ltd.	+86-17331136691	lemon@hbyinsheng.com	China	597	58

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• 6-Hydroxy-8-[(1R)-1-hydroxy-2-[[2-(4-methoxyphenyl)-1,1-dimethylethyl]amino]ethyl]-2H-1,4-benzoxazin-3(4H)-one
• 2H-1,4-Benzoxazin-3(4H)-one, 6-hydroxy-8-[(1R)-1-hydroxy-2-[[2-(4-methoxyphenyl)-1,1-dimethylethyl]amino]ethyl]-
• BI 1744(Olodaterol
• Striverdi Respimat)
• Olodaterol
• Olodaterol ImpurityＡ 　
• BI-1744
• Striverdi
• Olodaterol, 98%, a long acting β2-adrenoceptor agonist
• OLODATEROL;BI-1744;STRIVERDI
• Olodaterol, 6-Hydroxy-8-[(1r)-1-hydroxy-2-[[2-(4-methoxyphenyl)-1,1-dimethylethyl]amino]ethyl]-2h-1,4-benzoxazin-3(4h)-one
• STRIVERDI RESPIMAT; BI 1744; BI1744
• (R)-6-hydroxy-8-(1-hydroxy-2-((1-(4-methoxyphenyl)-2-methylpropan-2-yl)amino)ethyl)-2H-benzo[b][1,4]oxazin-3(4H)-one
• 6 - hydroxy - 8 - [(1 r) - 1 - hydroxy - 2 - [[2 - (4 - methoxy phenyl) - 1, 1-2 methyl ethyl] amino] ethyl] - 2 h - 1, 4 - benzo oxazine - 3 (4 h) - one
• Olodaterol USP/EP/BP
• Olodaterol Discontinued
• OLODATEROL D3
• Olodaterol D3 HydrochlorideQ: What is Olodaterol D3 Hydrochloride Q: What is the CAS Number of Olodaterol D3 Hydrochloride Q: What are the applications of Olodaterol D3 Hydrochloride
• Olodaterol free base
• 6-hydroxy-8-(1-hydroxy-2-((2-(4-methoxyphenyl)-1,1-dimethylethyl)amino)ethyl)-2H-1,4-benzoxazin-3(4H)-one
• Odaro
• 868049-49-4