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Merck SIP Agonist

Merck SIP Agonist Struktur
635701-59-6
CAS-Nr.
635701-59-6
Englisch Name:
Merck SIP Agonist
Synonyma:
CS-126;CAY10734;Merck SIP Agonist;SHQNRSGKLNMHOS-UHFFFAOYSA-N;1-(4-(5-(4-Isobutylphenyl)-1,2,4-oxadiazol-3-yl)benzyl)azetidine-3-carboxylic acid;butylphenyl)-1,2,4-oxadiaz1-(4-(5-(4-isool-3-yl)benzyl)azetidine-3-carboxylic acid;1-[4-[5-[4-(2-Methylpropyl)phenyl]-1,2,4-oxadiazol-3-yl]benzyl]azetidine-3-carboxylic acid;1-[[4-[5-[4-(2-methylpropyl)phenyl]-1,2,4-oxadiazol-3-ly]phenyl]methyl]-3-Azetidinecarboxylic acid;3-Azetidinecarboxylic acid, 1-[[4-[5-[4-(2-methylpropyl)phenyl]-1,2,4-oxadiazol-3-yl]phenyl]methyl]-
CBNumber:
CB51872315
Summenformel:
C23H25N3O3
Molgewicht:
391.46
MOL-Datei:
635701-59-6.mol

Merck SIP Agonist Eigenschaften

Siedepunkt:
565.9±60.0 °C(Predicted)
Dichte
1.228±0.06 g/cm3(Predicted)
storage temp. 
Store at -20°C
L?slichkeit
DMF: 5 mg/ml; DMF:PBS (pH 7.2) (1:10): 0.1 mg/ml; Ethanol: Partially soluble
Aggregatzustand
A crystalline solid
pka
2.66±0.20(Predicted)

Sicherheit

Merck SIP Agonist Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

CAY10734 is an agonist of sphingosine-1-phosphate receptor 1 (S1P1; IC50 = 0.6 nM). It selectively binds S1P1 over S1P2, S1P3, and S1P4 receptors (IC50s = >10,000, 12,000, and 70 nM, respectively) but does also bind S1P5 receptors (IC50 = 1 nM) in radioligand binding assays. CAY10734 reduces the number of peripheral blood lymphocytes in mice, rats, and dogs, with the maximal response achieved when administered at doses of 10, 0.5, and 0.5 mg/kg, respectively. It increases graft survival in a rat skin allograft model when administered at a dose of 5 mg/kg per day in combination with cyclosporin A (CsA; ).

Merck SIP Agonist Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

Merck SIP Agonist Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 28)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Alchem Pharmtech,Inc. 		8485655694
sales@alchempharmtech.com United States 63687 58
CONIER CHEM AND PHARMA LIMITED 		+8618523575427
 sales@conier.com China 49732 58
TargetMol Chemicals Inc. 		+17819995354
 marketing@targetmol.com United States 32282 58
Hangzhou MolCore BioPharmatech Co.,Ltd. 		+86-057181025280; +8617767106207
 sales@molcore.com China 49734 58
BOC Sciences 1-631-485-4226; 16314854226
 info@bocsci.com United States 12952 65
Nanjing Norris-Pharm Technology Co., Ltd 13901585132
 799750417@qq.com China 8878 55
AdooQ BioScience, LLC +1 (866) 930-6790
info@adooq.com United States 2782 58
BOC Sciences 16314854226
 info@bocsci.com United States 9923 65
Shanghai EFE Biological Technology Co., Ltd. 021-65675885 18964387627
 info@efebio.com China 9803 58
Nanjing KaiMubo Pharmaceutical Co., Ltd. 025-66162170
China 7181 55
  • Merck SIP Agonist
  • butylphenyl)-1,2,4-oxadiaz1-(4-(5-(4-isool-3-yl)benzyl)azetidine-3-carboxylic acid
  • 1-(4-(5-(4-Isobutylphenyl)-1,2,4-oxadiazol-3-yl)benzyl)azetidine-3-carboxylic acid
  • 3-Azetidinecarboxylic acid, 1-[[4-[5-[4-(2-methylpropyl)phenyl]-1,2,4-oxadiazol-3-yl]phenyl]methyl]-
  • 1-[4-[5-[4-(2-Methylpropyl)phenyl]-1,2,4-oxadiazol-3-yl]benzyl]azetidine-3-carboxylic acid
  • CS-126
  • CAY10734
  • SHQNRSGKLNMHOS-UHFFFAOYSA-N
  • 1-[[4-[5-[4-(2-methylpropyl)phenyl]-1,2,4-oxadiazol-3-ly]phenyl]methyl]-3-Azetidinecarboxylic acid
  • 635701-59-6
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