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Dotinurad

Dotinurad Struktur
1285572-51-1
CAS-Nr.
1285572-51-1
Englisch Name:
Dotinurad
Synonyma:
Dotinurad;Duotenuode;Duotenuolei;Doltenolil control;Dotinurad (FYU-981);Dotinurad, 10 mM in DMSO;3-(3,5-dichloro-4-hydroxybenzoyl)-1,1-dioxo-2,3-dihydro-1,3-benzothiazole;(3,5-Dichloro-4-hydroxyphenyl)(1,1-dioxido-3(2H)-benzothiazolyl)methanone;(3,5-dichloro-4-hydroxyphenyl)(1,1-dioxidobenzo[d]thiazol-3(2H)-yl)methanone;Methanone, (3,5-dichloro-4-hydroxyphenyl)(1,1-dioxido-3(2H)-benzothiazolyl)-
CBNumber:
CB44667832
Summenformel:
C14H9Cl2NO4S
Molgewicht:
358.2
MOL-Datei:
1285572-51-1.mol

Dotinurad Eigenschaften

Schmelzpunkt:
188 - 191°C
Siedepunkt:
614.8±55.0 °C(Predicted)
Dichte
1.662±0.06 g/cm3(Predicted)
storage temp. 
-20°C Freezer, Under inert atmosphere
L?slichkeit
Chloroform (Slightly, Sonicated), DMSO (Sparingly)
pka
4.60±0.25(Predicted)
Aggregatzustand
Solid
Farbe
White to Off-White
InChI
InChI=1S/C14H9Cl2NO4S/c15-9-5-8(6-10(16)13(9)18)14(19)17-7-22(20,21)12-4-2-1-3-11(12)17/h1-6,18H,7H2
InChIKey
VOFLAIHEELWYGO-UHFFFAOYSA-N
SMILES
C(C1=CC(Cl)=C(O)C(Cl)=C1)(N1C2=CC=CC=C2S(=O)(=O)C1)=O

Sicherheit

Dotinurad Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

Dotinurad is an organic compound with the chemical Name (3,5-dichloro-4-hydroxyphenyl)(1,1-dioxidobenzo[d]thiazol-3(2H)-yl)methanone. This compound is a newer urate-lowering agent that suppresses uric acid reabsorption through the selective inhibition of urate transporter 1 (URAT1) in the proximal renal tubules, and it was first approved in Japan in 2020 for the treatment of hyperuricemia, irrespective of gout[1].

Verwenden

Dotinurad is a useful drug for treating hyperuricemia and gout.

Trademarks

URECE

Synthese

Aminothiophenol (152) reacts with hydrated formaldehyde to give dihydrobenzothiazole 153. Acid chloride 155 is generated from acid 154. Dihydrobenzothiazole 153 is condensed with acid chloride 155 to form amide 156. Thiazole is oxidized using mCPBA. Methyl ether is removed in the presence of lithium chloride to give doxenolide.
Dotinurad

Dotinurad Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

Dotinurad Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 130)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Zhejiang Hengkang Pharmaceutical Co.Ltd. 		+undefined13858064988
 wujiling@hengkangpharm.cn China 44 58
BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD.
+86-18600796368 +86-18600796368
 sales@sjar-tech.com China 485 58
ShenZhen H&D Pharmaceutical Technology Co., LTD 		+8618627948422
 sale@hdimpurity.com China 3681 58
Guangzhou Tosun Pharmaceutical Ltd 		+86-020-61855200-902 +8618124244216
 info@upharm.cn China 897 58
TargetMol Chemicals Inc. 		+17819995354
 marketing@targetmol.com United States 32281 58
Henan Alfa Chemical Co., Ltd 		+8615838112936
 alfa10@alfachem.cn China 13184 58
Nextpeptide Inc 		+86-0571-81612335 +8613336028439
 sales@nextpeptide.com China 19908 58
InvivoChem 		+1-708-310-1919 +1-13798911105
 sales@invivochem.cn United States 6391 58
Huadong Medicine (Xi'an)Bodyguard Pharmaceutical Co.,Ltd. 		+86-029-86185165 +8618629664246
 guoyuan@eastchinapharm.com China 1615 58
Hangzhou MolCore BioPharmatech Co.,Ltd. 		+86-057181025280; +8617767106207
 sales@molcore.com China 49734 58
  • Dotinurad
  • Methanone, (3,5-dichloro-4-hydroxyphenyl)(1,1-dioxido-3(2H)-benzothiazolyl)-
  • Dotinurad (FYU-981)
  • (3,5-dichloro-4-hydroxyphenyl)(1,1-dioxidobenzo[d]thiazol-3(2H)-yl)methanone
  • uricosuric,Inhibitor,Dotinurad,URAT1,urate,reabsorption,SLC22A12,Urate transporter 1,inhibit,transporter
  • (3,5-Dichloro-4-hydroxyphenyl)(1,1-dioxido-3(2H)-benzothiazolyl)methanone
  • 3-(3,5-dichloro-4-hydroxybenzoyl)-1,1-dioxo-2,3-dihydro-1,3-benzothiazole
  • Dotinurad, 10 mM in DMSO
  • Doltenolil control
  • Duotenuolei
  • Duotenuode
  • 1285572-51-1
  • API
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