Tivozanib (hydrate) Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

Tivozanib is an orally available, selective VEGFR inhibitor with IC₅₀ values of 0.21, 0.16, and 0.24 nM for VEGFR1, VEGFR2, and VEGFR3, respectively. It can also inhibit c-Kit and PDGFRβ with IC₅₀ values of 1.63 and 1.72 nM, respectively. When administered to athymic rats, tivozanib was shown to decrease the microvessel density within tumor xenografts and attenuate VEGFR2 phosphorylation levels in tumor endothelium. It also displays antitumor activity against a wide variety of human tumor xenografts, including lung, breast, colon, ovarian, pancreas, and prostate cancer.

Tivozanib (hydrate) Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

Tivozanib (hydrate) Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Firmenname	Telefon	E-Mail	Land	Produktkatalog	Edge Rate
Shanghai Hanhong Scientific Co., Ltd.	+undefined17612118332	Lucky@hanhonggroup.com	China	6035	58
BOC Sciences	--	info@bocsci.com	USA	0	65
ChemeGen(Shanghai) Biotechnology Co.,Ltd.	18818260767	sales@chemegen.com	China	11218	58
MedBioPharmaceutical Technology Inc	021-69568360 18916172912	order@med-bio.cn	China	8140	58
Shanghai Yifei Biotechnology Co. , Ltd.	021-65675885 18964387627	customer_service@efebio.com	China	11973	58
Cayman Chemical Company	800-364-9897	sales@caymanchem.com	China	6838	58
ApexBio Technology	--	sales@apexbt.com	United States	6251	58
Shenzhen Science Biology Co., Ltd.	18617181553		CHINA	0	58
Guangzhou Squirrel Biotechnology Co., Ltd.	17765276361		CHINA	0	58
Guangzhou Chuangze Biotechnology Co., Ltd.	18312220236		CHINA	0	58

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• Tivozanib (hydrate)
• N-[2-chloro-4-[(6,7-dimethoxy-4-quinolinyl)oxy]phenyl]-N'-(5-methyl-3-isoxazolyl)-urea,monohydrate
• 682745-40-0
• C22H19ClN4O5H2O