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Rifamycin

RIFAMYCIN SV Struktur
6998-60-3
CAS-Nr.
6998-60-3
Bezeichnung:
Rifamycin
Englisch Name:
RIFAMYCIN SV
Synonyma:
rifocyn;rifocin;rifamicinesv;RIFAMYCIN SV;RIFAMYCIN INN;Rifamycin S-Na;Rifamycin (9CI);RIFAMYCIN SV USP/EP/BP;Rifaximin EP Impurity C;Rifaximin impurity C (EP)
CBNumber:
CB2731058
Summenformel:
C37H47NO12
Molgewicht:
697.77
MOL-Datei:
6998-60-3.mol

Rifamycin Eigenschaften

Schmelzpunkt:
300° (dec 140°)
alpha 
D20 -4° (methanol)
Siedepunkt:
701.9°C (rough estimate)
Dichte
1.2275 (rough estimate)
Brechungsindex
1.5350 (estimate)
pka
5.17±0.70(Predicted)

Sicherheit

Toxizit?t LD50 in mice (mg/kg): 550 i.v.; 625 i.p.; 2120 orally (Bergamini, Fowst)

Rifamycin Chemische Eigenschaften,Einsatz,Produktion Methoden

Verwenden

Rifogal (Rifaximin EP Impurity C NA) is a antibacterial drug which functions by inhibiting bacterial RNA polymerase (RNAP), is an important part of the antibacteral armamentarium. Also, it is one of the few drugs in a multidrug regimens for treating lung disease (LD) due to Mycobacterium avium complex (MAC).

Definition

ChEBI: A member of the class of rifamycins that exhibits antibiotic and antitubercular properties.

Pharmazeutische Anwendungen

The simplest rifamycin in clinical use, obtained by elimination of a glycolic moiety from rifamycin B. Formulated as sodium salt for parenteral administration. Also available for topical use. Its activity, general properties and pharmacokinetics are very similar to those of rifamide. It is orally absorbed and excreted mainly in the bile. Intramuscular doses of 250 mg produce mean plasma levels of about 2 mg/L. The plasma half-life is around 2 h.
In addition to uses similar to those of rifamide, it is administered topically in surgery and has been proposed for the treatment of synovitis by intra-articular injections. A topical preparation is used for application to wounds and bedsores. Cases of anaphylactic reactions have been reported after local administration of the drug.

l?uterung methode

Rifamycin SV gives yellow-orange crystals from Et2O/pet ether or aqueous EtOH, is very soluble in MeOH, EtOH, Me2CO and EtOAc, and is less soluble in Et2O and HCO3-, but slightly soluble in H2O and pet ether. Its UV has max at 223, 314 and 445nm ( 1cm 586, 322 and 204) in phosphatebuffer pH 7. [NMR: Bergamini & Fowst Arzneim.-Forsch 15 951 1965.]

Rifamycin Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Rifamycin Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 94)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Shanghai Daken Advanced Materials Co.,Ltd
+86-2158073036
info@dakenam.com China 19886 58
Shanghai Bojing Chemical Co.,Ltd.
+86-86-02137122233 +8613795318958
bj1@bj-chem.com China 299 55
Henan Tianfu Chemical Co.,Ltd.
+86-0371-55170693 +86-19937530512
info@tianfuchem.com China 21626 55
Hubei Jusheng Technology Co.,Ltd.
18871490254
linda@hubeijusheng.com CHINA 28172 58
Standardpharm Co. Ltd.
86-714-3992388
overseasales1@yongstandards.com United States 14332 58
BOC Sciences
+1-631-485-4226
inquiry@bocsci.com United States 19552 58
career henan chemical co
+86-0371-86658258 +8613203830695
factory@coreychem.com China 29807 58
TargetMol Chemicals Inc.
+17819995354
marketing@targetmol.com United States 32277 58
Hefei TNJ Chemical Industry Co.,Ltd.
+86-0551-65418671 +8618949823763
sales@tnjchem.com China 34563 58
Hebei Zhanyao Biotechnology Co. Ltd
15369953316 +8615369953316
admin@zhanyaobio.com China 2123 58

6998-60-3(Rifamycin)Verwandte Suche:


  • RIFAMYCIN SV
  • 17,19,21-hexahydroxy-23-methoxy-2,4,12,16,18,20,22-heptamethyl-21-acetate
  • rifamicinesv
  • rifocin
  • rifocyn
  • Rifamycin S-Na
  • Rifaximin EP Impurity C
  • 19,21,25(29),26-octaen-13-yl acetate
  • Rifaximin impurity C (EP)
  • Rifaximin Impurity 3 (Rifaximin EP Impurity C)
  • Rifampicin Impurit Ⅱ:rifamycin SV
  • Rifaximin EP Impurity C (Rifamycin SV)
  • Rifamycin (9CI)
  • RIFAMYCIN SV USP/EP/BP
  • (2S,12Z,14E,16S,17S,18R,19R,20R,21S,22R,23S,24E)-21-(Acetyloxy)-5,6,9,17,19-pentahydroxy-23-methoxy-2,4,12,16,18,20,22-heptamethyl-2,7-(epoxypentadeca[1,11,13]trienimino)naphtho[2,1-b]furan-1,11(2H)-dione
  • RifamycinQ: What is Rifamycin Q: What is the CAS Number of Rifamycin Q: What is the storage condition of Rifamycin Q: What are the applications of Rifamycin
  • RIFAMYCIN INN
  • Rifaximin EP Impurity C (Rifamycin)
  • 6998-60-3
  • C37H47NO12
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