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ANTI-FIBROBLAST GROWTH FACTOR RECEPTOR-2 (FGFR-2), EXTRACELLULAR

ANTI-FIBROBLAST GROWTH FACTOR RECEPTOR-2 (FGFR-2), EXTRACELLULAR Struktur
CAS-Nr.
Englisch Name:
ANTI-FIBROBLAST GROWTH FACTOR RECEPTOR-2 (FGFR-2), EXTRACELLULAR
Synonyma:
Anti-FGFR-2;ANTI-FIBROBLAST GROWTH FACTOR RECEPTOR-2 (FGFR-2), EXTRACELLULAR;Anti-Fibroblast Growth Factor Receptor-2, Cytoplasmic antibody produced in rabbit;Anti-Fibroblast Growth Factor Receptor-2, Extracellular antibody produced in rabbit
CBNumber:
CB2281311
Summenformel:
Molgewicht:
0
MOL-Datei:
Mol file

ANTI-FIBROBLAST GROWTH FACTOR RECEPTOR-2 (FGFR-2), EXTRACELLULAR Eigenschaften

storage temp. 
-20°C
Aggregatzustand
buffered aqueous solution
Biologische Quelle
rabbit

Sicherheit

WGK Germany  2

ANTI-FIBROBLAST GROWTH FACTOR RECEPTOR-2 (FGFR-2), EXTRACELLULAR Chemische Eigenschaften,Einsatz,Produktion Methoden

Verwenden

Anti-Fibroblast Growth Factor Receptor-2, Extracellular antibody produced in rabbit has been used in immunoprecipitation and immunoblotting.

Allgemeine Beschreibung

Fibroblast growth factors receptors (FGFRs) are members of the tyrosine kinase family of growth factor receptors. They are glycosylated 110-150 k Da proteins that are constructed of an extracellular ligand binding region with either two or typically three immunoglobulin (Ig)-like domains and an eight amino acid ′acidic box′, a transmembrane region and a cytoplasmic split tyrosine kinase domain that is activated following ligand binding and receptor dimerization. At the mRNA level, FGFR-2 is highly expressed in developing human tissues including the brain (preferentially in glial cells), choroid plexus, skin, lung, kidney and bone. It is widely expressed in many adult human and animal tissues. It may be found in several anchorage-dependent cells, such as normal and malignant breast cancer cells.

Biochem/physiol Actions

Fibroblast growth factors (FGFs) are potent physiological regulators normal development, wound healing and repair, angiogenesis, a variety of neurotrophic activities, in hematopoiesis as well as in tissue remodeling and maintenance. FGFRs exhibit overlapping recognition and redundant specificity. Signal transduction by FGFRs requires dimerization or oligomerization and autophosphorylation of the receptors through their tyrosine kinase domain. Subsequent association with cytoplasmic signaling molecules leads to DNA synthesis or differentiation. The signaling and biological responses elicited by distinct FGFRs substantially differ. FGFR-2 is highly expressed in developing human tissues including the brain (preferentially in glial cells), choroid plexus, skin, lung, kidney and bone. It may be found in several anchorage-dependent cells, such as normal and malignant breast cancer cells.

ANTI-FIBROBLAST GROWTH FACTOR RECEPTOR-2 (FGFR-2), EXTRACELLULAR Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


ANTI-FIBROBLAST GROWTH FACTOR RECEPTOR-2 (FGFR-2), EXTRACELLULAR Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 15)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Atlas antibodies 46-854595850
order@atlasantibodies.com China 6586 58
Merck KGaA 21-20338288
ordercn@merckgroup.com China 6394 58
Guangzhou Kati Biotechnology Co., Ltd. 13128698830
CHINA 0 58

  • Anti-Fibroblast Growth Factor Receptor-2, Cytoplasmic antibody produced in rabbit
  • Anti-Fibroblast Growth Factor Receptor-2, Extracellular antibody produced in rabbit
  • ANTI-FIBROBLAST GROWTH FACTOR RECEPTOR-2 (FGFR-2), EXTRACELLULAR
  • Anti-FGFR-2
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