DL-TBOA
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DL-TBOA Eigenschaften
- Siedepunkt:
- 421.7±45.0 °C(Predicted)
- Dichte
- 1.392±0.06 g/cm3(Predicted)
- storage temp.
- Desiccate at -20°C
- L?slichkeit
- <23.92mg/ml in DMSO;insoluble in H2O
- Aggregatzustand
- solid
- pka
- 2.07±0.27(Predicted)
- Farbe
- White
Sicherheit
DL-TBOA Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
DL-TBOA is an inhibitor of excitatory amino acid transporters (EAATs), with IC50 values of 67 and 5.5 μM for glutamate uptake in COS-1 cells expressing human EAAT1 and EAAT2, respectively. It inhibits inward currents induced by L-aspartate in EAAT4-expressing Xenopus oocytes (Ki = 4.4 μM) and by L-glutamate in EAAT5-expressing oocytes (Ki = 3.2 μM) voltage-clamped at -60 mV. In vivo, DL-TBOA (500 μM, intrahippocampal perfusion) increases extracellular aspartate, glutamate, and alanine levels in rat hippocampus. Intrahippocampal injection of DL-TBOA increases lesion volume in the rat CA1 region in a dose-dependent manner and induces hyperexcitability, wet-dog shakes, salivation, forelimb myoclonus, limbic seizures, and epileptic EEG discharges at a dose of 25 nmol. DL-TBOA (5 and 10 μg, intrathecal) induces antinociception in the second phase of the formalin test in rats when administered 10 minutes prior to formalin.Verwenden
DL-TBOA is a non-transportable excitatory amino acid transporter (EAAT) inhibitor (1). DL-TBOA is a glutamate uptake inhibitor.DL-TBOA Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
DL-TBOA Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 43)Lieferanten
Firmenname | Telefon | Land | Produktkatalog | Edge Rate | |
---|---|---|---|---|---|
TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 |
marketing@targetmol.com | United States | 32376 | 58 |
Aladdin Scientific | |
tp@aladdinsci.com | United States | 52924 | 58 |
3B Pharmachem (Wuhan) International Co.,Ltd. | 821-50328103-801 18930552037 |
3bsc@sina.com | China | 15839 | 69 |
EMMX Biotechnology LLC | 888-539-0666 |
info@emmx.com | United States | 8447 | 60 |
Fan De(Beijing) Biotechnology Co., Ltd. | 15911056312 |
liming@bio-fount.com | China | 9729 | 58 |
BOC Sciences | -- |
info@bocsci.com | USA | 0 | 65 |
Jiangsu Hongmin Pharmaceutical Co., Ltd. | 18221292452 |
fannieliu@glschina.com | China | 6798 | 58 |
MedBioPharmaceutical Technology Inc | 021-69568360 18916172912 |
order@med-bio.cn | China | 8140 | 58 |
Energy Chemical | 021-58432009 400-005-6266 |
marketing@energy-chemical.com | China | 44918 | 58 |
Beijing Jin Ming Biotechnology Co., Ltd. | 010-60605840 15801484223; |
psaitong@jm-bio.com | China | 29770 | 58 |
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