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Phenoxybenzamin

phenoxybenzamine Struktur
59-96-1
CAS-Nr.
59-96-1
Bezeichnung:
Phenoxybenzamin
Englisch Name:
phenoxybenzamine
Synonyma:
Phenoxy;Dibenyline;Phenoxybenzamin;phenoxybenzamine USP/EP/BP;N-Benzyl-N-(2-chloroethyl)-1-phenoxypropan-2-aMine;N-(2-Chloroethyl)-N-(1-methyl-2-phenoxyethyl)benzylamine;BENZYLAMINE,N-(2-CHLOROETHYL)-N-(1-METHYL-2-PHENOXYETHYL)-;Benzenemethanamine, N-(2-chloroethyl)-N-(1-methyl-2-phenoxyethyl)-
CBNumber:
CB1933947
Summenformel:
C18H22ClNO
Molgewicht:
303.83
MOL-Datei:
59-96-1.mol

Phenoxybenzamin Eigenschaften

Schmelzpunkt:
38-40°
Siedepunkt:
381.5±27.0 °C(Predicted)
Dichte
1.0513 (rough estimate)
Brechungsindex
1.5600 (estimate)
pka
6.58±0.50(Predicted)
Farbe
Crystals from pet ether
CAS Datenbank
59-96-1
EPA chemische Informationen
N-(2-Chloroethyl)-N-(1-methyl-2-phenoxyethyl)benzenemethanamine (59-96-1)

Sicherheit

Giftige Stoffe Daten 59-96-1(Hazardous Substances Data)
Toxizit?t LD50 oral in rat: 2500mg/kg

Phenoxybenzamin Chemische Eigenschaften,Einsatz,Produktion Methoden

Verwenden

Antihypertensive.

Weltgesundheitsorganisation (WHO)

Phenoxybenzamine, a long-acting alpha-adrenoreceptor antagonist, was introduced in 1953 and has been used in a variety of peripheral vascular disorders. In 1982 it was shown to have mutagenic activity and in 1985 it was found to be carcinogenic in the rat. Its approved use was subsequently restricted by several regulatory authorities and phenoxybenzamine is currently used to manage hypertensive episodes associated with phaeochromocytoma, as an adjunct to the short-term management of urinary retention due to neurogenic bladder, in the short-term treatment of benign prostatic hypertrophy in patients awaiting surgery, and in inoperable benign prostatic hypertrophy.

Sicherheitsprofil

Confirmed carcinogen with experimental carcinogenic and neoplastigenic data. Poison by intravenous and intracerebral routes. Moderately toxic by ingestion. Human reproductive effects by ingestion: spermatogenesis. Experimental reproductive effects. When heated to decomposition it emits very toxic fumes of Cland NOx.

l?uterung methode

The free base is crystallised from pet ether, and the HCl is crystallised from EtOH/diethyl ether. [Beilstein 12 IV 2204.]

Phenoxybenzamin Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Phenoxybenzamin Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 23)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
TargetMol Chemicals Inc.
+1-781-999-5354 +1-00000000000
marketing@targetmol.com United States 32159 58
Shaanxi Dideu Medichem Co. Ltd
+86-029-89586680 +86-18192503167
1026@dideu.com China 7722 58
Finetech Industry Limited
+86-27-87465837 +8618971612321
info@finetechnology-ind.com China 9638 58
Dayang Chem (Hangzhou) Co.,Ltd.
571-88938639 +8617705817739
info@dycnchem.com China 52849 58
GIHI CHEMICALS CO.,LIMITED
+8618058761490
info@gihichemicals.com China 49985 58
Beijing HuaMeiHuLiBiological Chemical 010-56205725
waley188@sohu.com China 12335 58
Finetech Industry Limited 027-87465837 19945049750
sales@finetechnology-ind.com China 9647 58
Chengdu Saint - Kay Biotechnology Co., Ltd. 028-85157043 15882256948
676046971@qq.com China 4399 58
Wuhan pengyin Pharmaceutical Co., Ltd 13163333255
1939328613@qq.com China 395 58

59-96-1(Phenoxybenzamin)Verwandte Suche:


  • Phenoxybenzamin
  • Phenoxy
  • BENZYLAMINE,N-(2-CHLOROETHYL)-N-(1-METHYL-2-PHENOXYETHYL)-
  • Dibenyline
  • N-(2-Chloroethyl)-N-(1-methyl-2-phenoxyethyl)benzylamine
  • N-Benzyl-N-(2-chloroethyl)-1-phenoxypropan-2-aMine
  • Benzenemethanamine, N-(2-chloroethyl)-N-(1-methyl-2-phenoxyethyl)-
  • phenoxybenzamine USP/EP/BP
  • 59-96-1
  • Isotopically Labeled Pharmaceutical Reference Standard
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