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"6,7-diphenyl-2-sulfanylidene-1H-pteridin-4-one

14892-97-8
CAS-Nr.
14892-97-8
Englisch Name:
"6,7-diphenyl-2-sulfanylidene-1H-pteridin-4-one
Synonyma:
-2-suL;6,7-diphenyL;SCR7 pyrazine;SCR7; SCR-7; SCR 7.;6,7-Diphenyl-2-thiolumazine;SCR7 pyrazine, 10 mM in DMSO;SCR7 pyrazine, NHEJ inhibitor;6,7-Diphenyl-2-sulfanylpteridin-4-ol;"6,7-diphenyl-2-sulfanylidene-1H-pteridin-4-one;2,3-Dihydro-6,7-diphenyl-2-thioxo-4(1H)-pteridinone
CBNumber:
CB12741690
Summenformel:
C18H12N4OS
Molgewicht:
332.38
MOL-Datei:
14892-97-8.mol

"6,7-diphenyl-2-sulfanylidene-1H-pteridin-4-one Eigenschaften

Schmelzpunkt:
209 °C
Dichte
1.42±0.1 g/cm3(Predicted)
storage temp. 
room temp
L?slichkeit
DMSO (Slightly), Methanol (Slightly)
pka
4.14±0.60(Predicted)
Aggregatzustand
powder
Farbe
faintly yellow to dark yellow
CAS Datenbank
14892-97-8
Sicherheit
  • Risiko- und Sicherheitserkl?rung
  • Gefahreninformationscode (GHS)
HS Code  2933.59.8000
Bildanzeige (GHS) GHS hazard pictograms
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H302 Gesundheitssch?dlich bei Verschlucken. Akute Toxizit?t oral Kategorie 4 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P270, P301+P312, P330, P501
Sicherheit

"6,7-diphenyl-2-sulfanylidene-1H-pteridin-4-one Chemische Eigenschaften,Einsatz,Produktion Methoden

Verwenden

SCR7 pyrazine has been used as a non-homologous end joining (NHEJ) modulator to study its effect on CRISPR/Cas9-mediated editing.

Allgemeine Beschreibung

SCR7 pyrazine is an inhibitor of DNA ligase IV.

Biochem/physiol Actions

SCR7 pyrazine is reported to be an inhibitor of non-homologous end joining (NHEJ) and has been shown to enhance the efficiency of CRISPR-Cas9 genome editing. The effect of SCR7 pyrazine on the efficiency and targeting precision of CRISPR applications has been shown to be cell type specific and context dependent. SCR7 pyrazine is a product of spontaneous cyclization of SCR7, first reported by Srivastava, M., et al.

"6,7-diphenyl-2-sulfanylidene-1H-pteridin-4-one Upstream-Materialien And Downstream Produkte

Upstream-Materialien

4,5-Diamino-2-mercaptopyrimidin-6-ol Benzaldehyd Benzoin Benzil

Downstream Produkte

"6,7-diphenyl-2-sulfanylidene-1H-pteridin-4-one Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

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  • "6,7-diphenyl-2-sulfanylidene-1H-pteridin-4-one
  • 6,7-Diphenyl-2-thiolumazine
  • SCR7 pyrazine
  • 6,7-Diphenyl-2-sulfanylpteridin-4-ol
  • 2,3-Dihydro-6,7-diphenyl-2-thioxo-4(1H)-pteridinone
  • SCR7; SCR-7; SCR 7.
  • 6,7-diphenyL
  • 4(1H)-Pteridinone, 2,3-dihydro-6,7-diphenyl-2-thioxo-
  • -2-suL
  • 6,7-Diphenyl-2-thioxo-2,3-dihydropteridin-4(8H)-one
  • 6,7-Diphenyl-2-thioxo-2,3-dihydropteridin-4(1H)-one
  • phosphorylation,nonhomologous,Caspase 9,Inhibitor,gene,DNA/RNA Synthesis,end-joining,Apoptosis,DNA,SCR7 pyrazine,replacement,SCR-7 pyrazine,CRISPR/Cas9,ligase-IV,Caspase 3,inhibit,anticancer
  • SCR7 pyrazine, NHEJ inhibitor
  • SCR7 pyrazine, 10 mM in DMSO
  • 14892-97-8
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