Flavin-adenin-dinucleotid Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

Flavin adenine dinucleotide (FAD) is a cofactor for cytochrome-b5 reductase, the enzyme that maintains hemoglobin in its functional reduced state, and for glutathione reductase. This enzyme also protects erythrocytes from oxidative damage. FAD is a redox cofactor of several essential reactions in metabolism. This cofactor exists in two redox states, with FAD and FADH2 being the oxidized and reduced forms, respectively. FAD is formed of a riboflavin moiety (vitamin B2) coupled to a phosphate group of an ADP molecule. The reaction starts with the conversion of riboflavin into flavin mononucleotide catalyzed by riboflavin kinase. Flavin mononucleotide is subsequently transformed into FAD by adding an AMP moiety from ATP catalyzed by FAD-synthase. Therefore, FAD availability is tightly dependent on vitamin B2 and energy metabolism[1].

Chemische Eigenschaften

solid

Verwenden

Labelled Flavine Adenine xidase. Riboflavin kinase tumor necrosis factor receptor 1 NADPH oxidase

Definition

An adenine nucleotide containing two phosphate groups esterified to the sugar moiety at the 5′-position.

l?uterung methode

Small quantities of FAD are purified by paper chromatography using tert-butyl alcohol/water, cutting out the main spot and eluting with water. Larger amounts can be precipitated from water as the uranyl complex by adding a slight excess of uranyl acetate to a solution at pH 6.0, dropwise and with gentle stirring. The solution is set aside overnight in the cold, and the precipitate is centrifuged off, washed with small portions of cold EtOH, then with cold peroxide-free diethyl ether. It is dried in the dark under vacuum over P2O5 at 50-60o. The uranyl complex is suspended in water, and, after adding sufficient 0.01M NaOH to adjust the pH to 7, the precipitate of uranyl hydroxide is removed by centrifugation [Huennekens & Felton Methods Enzymol 3 954 1957]. It can also be crystallised from water. It should be kept in the dark. More recently it was purified by elution from a DEAE-cellulose (Whatman DE 23) column with 0.1M phosphate buffer pH 7, and the purity was checked by TLC. [Holt & Cotton, J Am Chem Soc 109 1841 1987, Beilstein 26 III/IV 3632.]

Flavin-adenin-dinucleotid Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

Flavin-adenin-dinucleotid Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Firmenname	Telefon	E-Mail	Land	Produktkatalog	Edge Rate
Maintain Biotech Co., Ltd.	+86-75589664337 +86-15112661142	cami@maintain-bio.com	China	63	58
Hebei Chuanghai Biotechnology Co., Ltd	+8617732866630	abby@chuanghaibio.com	China	8773	58
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21622	55
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29855	58
Hubei xin bonus chemical co. LTD	86-13657291602	linda@hubeijusheng.com	CHINA	22963	58
Shaanxi Dideu Medichem Co. Ltd	+86-29-87569262 +86-15003564040	1087@dideu.com	China	3298	58
Hebei Mujin Biotechnology Co.,Ltd	+86-13288715578	sales@hbmojin.com	China	12647	58
TargetMol Chemicals Inc.	+1-781-999-5354; +17819995354	marketing@targetmol.com	United States	32376	58
Dideu Industries Group Limited	+86-29-89586680 +86-15129568250	1026@dideu.com	China	22162	58
Sense Chemicals (Shanghai) Co., Ltd.	+86-21-52751036; +8613818977689	david.dai@sensechemicals.com	China	225	58

146-14-5(Flavin-adenin-dinucleotid)Verwandte Suche:

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• adenine-flavindinucleotide
• adenine-flavinedinucleotide
• adenine-riboflavindinuceotide
• flavitan
• isoalloxazine-adeninedinucleotide
• riboflavin5’-(trihydrogendiphosphate),5’.fwdarw.5’-esterwithadenosine
• riboflavin5’-(trihydrogendiphosphate),5’-5’-esterwithadenosine
• riboflavin-adeninedinucleotide
• riboflavine-adeninedinucleotide
• FLAVIN ADENINE DINUCLEOTIDE
• Flavine-adenine dinucleotide
• adenine-riboflavindinucleotide
• adenosine5’-(trihydrogenpyrophosphate),5’-5’-esterwithriboflavine
• flavinadenindinucleotide
• flavinadeninedinucleotidedisodium
• flavinat
• flavineadeninedinucleotide,disodiumflavineadeninedinucleotide
• flavineadenosinediphosphate
• FLAVIN ADENINE DINUCLEOTIDE 2NA (FAD)
• Riboflavine 5'-adenosine diphosphate
• Adenine-riboflavine dinucleotide
• Adenosine 5'-(trihydrogen pyrophosphate), 5'→5'-ester with riboflavine (8CI)
• Fademin
• NSC 112207
• Riboflavin 5'-adenosine diphosphate
• Riboflavine, 5'-ester with adenosine 5'-diphosphate (8CI)
• FLAVINE ADENINE DINUCLEOTIDE SODIUM SALT extrapure
• flavin adenosine dinucleotide
• Riboflavin 5-(trihydrogen diphosphate), P?5-ester with adenosine
• Riboflavin 5'-(trihydrogen diphosphate)
• 5'-ester with adenosine
• Riboflavin5'-(trihydrogen diphosphate), P'®
• Flavinin
• Wakadenin
• Flavine-adenine dinucleotide,96%
• Flavine Adenine
• Flavin adenine dinucleotide ,95%
• Flavine Adenine Dinucleotide Sodium Salt (FAD) extrapure, 95%
• flavine Adenine Dinucleotide-13C5 Ammonium SaltQ: What is flavine Adenine Dinucleotide-13C5 Ammonium Salt Q: What is the CAS Number of flavine Adenine Dinucleotide-13C5 Ammonium Salt
• FLAVIN ADENINE DINUCLEOTIDE USP/EP/BP
• DISODIUM FLAVINE ADENINE DINUCLEOTIDE
• FAD Powder
• (((2R,3S,4R,5R)-5-(6-Amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl)methoxy)(((((2R,3S,4S)-5-(7,8-dimethyl-2,4-dioxo-2H,3H,4H,10H-benzo[g]pteridin-10-yl)-2,3,4-trihydroxypentyl)oxy)(hydroxy)phosphoryl)oxy)phosphinic acid
• Flavine adenine dinucleotide,FAD
• Riboflavin5'-(trihydrogen diphosphate), P'?5'-ester with adenosine
• Active vitamin B2 disodium salt
• 146-14-5
• C2213C5H31N9Na2O15P2
• C27H31N9O15P2Na2
• C27H33N9O15P2
• C27N33N9O15P2
• Metabolic Pathways
• Metabolomics
• Electron Transport and Cellular Respiration
• Cofactors and Substrates
• BioChemical
• Biochemistry
• Vitamin Derivatives