乙氫去甲奎寧
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- CAS號:
- 522-60-1
- 英文名:
- ETHYLHYDROCUPREINE
- 英文別名:
- optochin;numoquin;optoquine;Optochine;Numoquine;Ethylhydrocuprein;ETHYLHYDROCUPREINE;hydrocupreineethylether;Hydrocupureine ethyl ether;6’-ethoxy-hydrocinchonidin
- 中文名:
- 乙氫去甲奎寧
- 中文別名:
- 乙氫去甲奎寧;乙基氫化脫甲奎寧;乙基氫化銅色樹堿;乙基氫化銅色金雞納堿;化合物 ETHYLHYDROCUPREINE;(R)-(6-乙氧基喹啉-4-基)((1S,2S,4S,5R)-5-乙基奎寧-2-基)甲醇
- CBNumber:
- CB4490364
- 分子式:
- C21H28N2O2
- 分子量:
- 340.46
- MOL File:
- 522-60-1.mol
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乙氫去甲奎寧化學性質(zhì)
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熔點:
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123-128° when solvent-free
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比旋光度:
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D25 -136.2° (alcohol)
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沸點:
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476.25°C (rough estimate)
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密度:
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1.1027 (rough estimate)
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折射率:
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1.6180 (estimate)
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儲存條件:
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2-8°C
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乙氫去甲奎寧性質(zhì)、用途與生產(chǎn)工藝
Ethylhydrocupreine (Optochin) 是一種具有抗菌作用的奎寧衍生物，具有抗肺炎鏈球菌 (S. pneumoniae) 的活性。Ethylhydrocupreine 還具有抗 Plasmodium falciparum 的抗瘧活性，IC50 為 25.75 nM。Ethylhydrocupreine 是一種 Gallus gallus 2 受體 (ggTas2r1，ggTas2r2 和 ggTas2r7) 激動劑。
S. pneumoniae
IC50: 25.75 nM (
Plasmodium falciparum
)
ggTas2r1,
ggTas2r2 and ggTas2r7
The mutation rate to Ethylhydrocupreine (Optochin) resistance is estimated using fluctuation analysis in three capsulated
S. pneumoniae
strains (
S. pneumoniae
D39 NCTC 7466,
S. pneumoniae
R6 ATCC BAA-255 and
S. pneumoniae
ATCC 49619). The exposure to subinhibitory concentrations of penicillin increased the mutation rate (expressed as mutation per cell division) to Ethylhydrocupreine (Optochin) resistance between 2.1- and 3.1-fold for all three strains studied.
The injection of 1 cc. of a 24 hour dextrose blood broth culture of virulent Type I pneumococci into the right pleural cavity of guinea pigs produces acute suppurative pleuritis on both sides associated with suppurative pericarditis. The injection of 1 cc. of 1:500 solutions of Ethylhydrocupreine hydrochloride into each pleural cavity of guinea pigs at varying intervals up to 24 hours after pleural infection has usually shown a marked curative influence. Similar results are observed with dogs.
乙氫去甲奎寧
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下游產(chǎn)品
522-60-1, 乙氫去甲奎寧 相關搜索:
- Miscellaneous
- 抑制劑
- 藥靶配體
- 乙氫去甲奎寧
- Analytical Chromatography Product Catalog
- Alphabetic
- Analytical Standards
- EQ - EZ
- C21H28N2O2
- 化合物 ETHYLHYDROCUPREINE
- (R)-(6-乙氧基喹啉-4-基)((1S,2S,4S,5R)-5-乙基奎寧-2-基)甲醇
- 乙基氫化銅色樹堿
- 乙基氫化銅色金雞納堿
- 乙基氫化脫甲奎寧
- 乙氫去甲奎寧
- 522-60-1
- (R)-(6-Ethoxyquinolin-4-yl)((1S,2S,4S,5R)-5-ethylquinuclidin-2-yl)methanol
- Cinchonan-9-ol, 6'-ethoxy-10,11-dihydro-, (8α,9R)-
- ETHYLHYDROCUPREINE
- o(sup6’)-ethyl-hydrocuprein
- numoquin
- hydrocupreineethylether
- 6’-ethoxy-hydrocinchonidin
- 6’-ethoxy-10,11-dihydro-,(8-alpha,9r)-cinchonan-9-o
- Cinchonan-9-ol,6'-ethoxy-10,11-dihydro-, (8a,9R)-
- Hydrocupureine ethyl ether
- Ethylhydrocuprein
- Optochine
- Numoquine
- ethylhydrocupreine free base*crystalline
- optoquine
- optochin