906-33-2
906-33-2 結(jié)構(gòu)式
基本信息
新綠原酸
5-咖啡奎寧酸
5-咖啡?？鼘幩?BR>5-咖啡酰奎尼酸
5-二咖啡?？鼘幩?BR>新綠原酸 10MG
新綠原酸(標(biāo)準(zhǔn)品)
新綠原酸(5-咖啡酰奎寧酸)
5-二咖啡?？鼘幩?新綠原酸
Einecs 212-997-1
Neochlorogenic aci
Nochlorogenic acid
Neochlorogenic acid
5-Caffeoylquinic acid
5-O-CAFFEOYLQUINICACID
Neochlorogenic acid(3')
5-Dicaffeoylquinic Acid
(E)-Neochlorogenic Acid
物理化學(xué)性質(zhì)
常見問題列表
綠原酸亦稱“綠吉酸”、“咖啡單寧酸”。分子式C16H18O9。分子量354.32。由水中得針狀結(jié)晶，為半水合物，110℃變?yōu)闊o(wú)水合物。熔點(diǎn)208℃，[α]D25-33.5°(水，C=1)，K=2.2×10-3(27℃)。有弱酸味并具收斂性。25℃時(shí)在水中溶解度為4%，較易溶于熱水，溶于乙醇、丙酮，微溶于乙酸乙酯，不溶于氯仿、乙醚和二硫化碳。與濃鹽酸共沸得藍(lán)色染料。能使溴水褪色，與濃碘化氫共沸得苯甲酸，與水在230℃共熱分解為苯酚，與稀鹽酸共熱分解為咖啡酸和金雞納酸等，室溫與稀堿作用只得咖啡酸和金雞納酸。
綠原酸為植物代謝的重要因素，綠原酸及其異構(gòu)體異綠原酸和新綠原酸也存在于雙子葉植物的果實(shí)、葉及其他組織中。綠原酸為3-咖啡酸喹寧酸。新綠原酸為5-咖啡酸喹寧酸。異綠原酸含三種咖啡酰喹寧酸類物質(zhì)，分別為4，5-二咖啡酰喹寧酸，3，4-二咖啡酰喹寧酸，3，5-二咖啡酰喹寧酸。
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p65
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IL-1β
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TNF-α
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COX-2
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Neochlorogenic acid (NCA) shows a reduction of lipopolysaccharide (LPS)-induced NO production by suppressing iNOS and COX-2 protein expression and production of pro-inflammatory cytokines, such as TNF-α and IL-1β, in BV2 microglia cells. In addition, phosphorylated p38 MAPK and NF-κB p65 are also inhibited by Neochlorogenic acid in activated microglia. iNOS and COX-2 levels are increased in LPS-induced BV2 cells, but this increase is significantly inhibited after treatment with 50 and 100 μM Neochlorogenic acid.