6631-94-3
6631-94-3 結(jié)構(gòu)式
基本信息
2-乙酰吩噻嗪
LABOTEST-BB LT00012652
methyl phenothiazin-2-yl ketone
2-Acetyl-10H-phenothiazine
物理化學(xué)性質(zhì)
制備方法
23699-65-2
6631-94-3
以1-(3-苯基氨基苯基)-乙酮為原料合成2-乙?；脏玎旱囊话悴襟E如下：首先，將苯胺與間乙酰基苯酚以1.2:1的質(zhì)量比加入反應(yīng)容器中，加熱至溶解。隨后，加入三氟甲磺酸（加入量為間乙?；椒淤|(zhì)量的0.025倍），在190℃下進(jìn)行脫水反應(yīng)。反應(yīng)過程中分離生成的水分。反應(yīng)6小時后終止。通過減壓蒸餾去除過量的苯胺，得到暗紅色固體，即3-乙?；桨罚ɑ衔顰）。接下來，將化合物A與硫（化合物A與硫的摩爾比為1:2.3）及250毫升丙酮（硫與單質(zhì)的總質(zhì)量為1摩爾）加入反應(yīng)容器中，加熱溶解形成透明液體。然后，加入碘（加入量為化合物A質(zhì)量的0.0125倍），在170℃下攪拌回流反應(yīng)。25分鐘后，反應(yīng)基本完成，停止攪拌，逐漸冷卻至120℃，此時可見黃色和黑色分層。小心傾出上層黃色液體，室溫冷卻后析出黃色固體。粗產(chǎn)物通過乙醇-水混合溶劑重結(jié)晶，得到淡黃色固體，即目標(biāo)產(chǎn)物2-乙?；脏玎?。本實(shí)施例的總收率為90.5%，HPLC純度為99.7%。
參考文獻(xiàn)：
[1] Patent: CN105461655, 2016, A. Location in patent: Paragraph 0033
[2] Patent: CN105481793, 2016, A. Location in patent: Paragraph 0038; 0041
| 報(bào)價日期 | 產(chǎn)品編號 | 產(chǎn)品名稱 | CAS號 | 包裝 | 價格 |
| 2025/05/22 | HY-12805 | 2-乙酰基吩噻嗪 ML171 | 6631-94-3 | 100mg | 200元 |
| 2025/05/22 | HY-12805 | 2-乙?；脏玎?BR>ML171 | 6631-94-3 | 10mM * 1mLin DMSO | 220元 |
| 2025/05/22 | A2815 | 2-乙酰基吩噻嗪 2-Acetylphenothiazine | 6631-94-3 | 5g | 370元 |
常見問題列表
| Target | Value |
|
NOX1
(HEK293) | 0.25 μM |
|
NOX3
(HEK293) | 3 μM |
|
NOX2
(HEK293) | 5 μM |
|
NOX4
(HEK293) | 5 μM |
|
xanthine oxidase
(HEK293) | 5.5 μM |
Nox1-dependent ROS generation has been shown to play a pivotal role in cell signaling, cell growth, angiogenesis, motility and blood pressure regulation. ML171 strongly blocks ROS generation in HT29 cells (IC 50 =0.129 μM) and only increasing over-expression of Nox1 can overcome the blockage of ROS generation caused by ML171 treatment in HEK293 cell system reconstituted with all the components required Nox1-dependent ROS generation. ML171 efficiently blocks ROS production measured by carboxy-H2-DCFDA staining as well as DPI used as a positive control. When ML171 is tested in HEK293-Nox1 reconstituted cell system, higher potency in blocking Nox1-dependent ROS generation is observed compared with the parental compound.