25990-37-8
中文名稱
印苦楝內(nèi)酯
英文名稱
nimbolide
CAS
25990-37-8
分子式
C27H30O7
分子量
466.52
MOL 文件
25990-37-8.mol
更新日期
2025/03/13 22:35:02
25990-37-8 結(jié)構(gòu)式
基本信息
中文別名
印苦楝內(nèi)酯 英文別名
nimbolideNSC 309909
(17R)-7α,15β:21,23-Diepoxy-6α-hydroxy-4,8-dimethyl-1-oxo-11-methoxycarbonyl-18,24-dinor-11,12-seco-5α-chola-2,13,20,22-tetrene-4α-carboxylic acid γ-lactone
methyl [(2aR,5aR,6S,6aR,8R,9aR,10aS,10bR,10cR)-8-furan-3-yl-2a,5a,6a,7-tetramethyl-2,5-dioxo-2a,5a,6,6a,8,9,9a,10a,10b,10c-decahydro-2H,5H-cyclopenta[d]naphtho[2,3-b:1,8-b''c'']difuran-6-yl]acetate
2H,5H-Cyclopenta[d']naphtho[1,8-bc:2,3-b']difuran-6-acetic acid, 8-(3-furanyl)-2a,5a,6,6a,8,9,9a,10a,10b,10c-decahydro-2a,5a,6a,7-tetramethyl-2,5-dioxo-, methyl ester, (2aR,5aR,6S,6aR,8R,9aR,10aS,10bR,10cR)-
所屬類別
化學(xué)試劑：其他酯類化合物物理化學(xué)性質(zhì)
熔點(diǎn)>223°C (dec.)
沸點(diǎn)608.6±55.0 °C(Predicted)
密度1.32±0.1 g/cm3(Predicted)
儲存條件Hygroscopic, -20°C Freezer, Under Inert Atmosphere
溶解度可溶于氯仿、乙酸乙酯
形態(tài)粉末
顏色淺米色至黃色
安全數(shù)據(jù)
警示詞警告
危險性描述H302
防范說明P301+P312+P330
RTECS號GY2370000
毒性hamster,LD50,intraperitoneal,> 500mg/kg (500mg/kg),Toxicology Letters. Vol. 30, Pg. 159, 1986.
應(yīng)用領(lǐng)域
用途1
Nimbolide, a natural triterpenoid present in the edible parts of the neem tree (Azadirachta indica), was found to be growth-inhibitory in human colon carcinoma HT-29 cells. Nimbolide treatment of cell
s at 2.5 - 10 渭M resulted in moderate to very strong growth inhibition.