| Identification | Back Directory | [Name]
nimbolide | [CAS]
25990-37-8 | [Synonyms]
nimbolide
NSC 309909
(17R)-7α,15β:21,23-Diepoxy-6α-hydroxy-4,8-dimethyl-1-oxo-11-methoxycarbonyl-18,24-dinor-11,12-seco-5α-chola-2,13,20,22-tetrene-4α-carboxylic acid γ-lactone
methyl [(2aR,5aR,6S,6aR,8R,9aR,10aS,10bR,10cR)-8-furan-3-yl-2a,5a,6a,7-tetramethyl-2,5-dioxo-2a,5a,6,6a,8,9,9a,10a,10b,10c-decahydro-2H,5H-cyclopenta[d]naphtho[2,3-b:1,8-b''c'']difuran-6-yl]acetate
2H,5H-Cyclopenta[d']naphtho[1,8-bc:2,3-b']difuran-6-acetic acid, 8-(3-furanyl)-2a,5a,6,6a,8,9,9a,10a,10b,10c-decahydro-2a,5a,6a,7-tetramethyl-2,5-dioxo-, methyl ester, (2aR,5aR,6S,6aR,8R,9aR,10aS,10bR,10cR)- | [Molecular Formula]
C27H30O7 | [MDL Number]
MFCD31924824 | [MOL File]
25990-37-8.mol | [Molecular Weight]
466.52 |
| Chemical Properties | Back Directory | [Melting point ]
>223°C (dec.) | [Boiling point ]
608.6±55.0 °C(Predicted) | [density ]
1.32±0.1 g/cm3(Predicted) | [storage temp. ]
Hygroscopic, -20°C Freezer, Under Inert Atmosphere | [solubility ]
Chloroform, Ethyl Acetate | [form ]
powder | [color ]
Light Beige to Yellow |
| Safety Data | Back Directory | [Symbol(GHS) ]
GHS07 | [Signal word ]
Warning | [Hazard statements ]
H302 | [Precautionary statements ]
P301+P312+P330 | [RTECS ]
GY2370000 | [Toxicity]
hamster,LD50,intraperitoneal,> 500mg/kg (500mg/kg),Toxicology Letters. Vol. 30, Pg. 159, 1986. |
| Hazard Information | Back Directory | [Chemical Properties]
Light Beige Solid | [Uses]
Nimbolide, a natural triterpenoid present in the edible parts of the neem tree (Azadirachta indica), was found to be growth-inhibitory in human colon carcinoma HT-29 cells. Nimbolide treatment of cells at 2.5 - 10 μM resulted in moderate to very strong gr | [Biological Activity]
Nimbolide exhibits anti-malarialanti-bacterialand anti-cancer activities. It has been shown to induce apoptosis in osteosarcoma cells and inhibits cell migration of these cells by modulating the expression of integrin αvβ5. In human renal carcinoma cellsnimbolide induced cell cycle arrestDNA damageand apoptosis.It has been shown to modulate autophagy and apoptosis in pancreatic cancer. | [storage]
Store at -20°C |
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