1552-42-7

基本信息
6-二甲氨基-3,3-雙(4-二甲基氨基苯基)苯酞
6-二甲氨基-3
3,3-BIS(P-DIMETHYLAMINOPHENYL)-6-DIMETHYLAMINOPHTHALIDE
6-(dimethylamino)-3,3-bis(4-(dimethylamino)phenyl)-1(3h)-isobenzofuranone
6-(DIMETHYLAMINO)-3,3-BIS[P-(DIMETHYLAMINO)PHENYL]PHTHALIDE
CRYSTAL VIOLET LACTONE
CVL
LABOTEST-BB LT00160000
Pergascript Blue I 2R
3,3-bis(p-Dimethylaminophenyl)-6-dimethylaminophthalate
6-(dimethylamino)-3,3-bis[4-(dimethylamino)phenyl]-1(3h)-isobenzofuranon
6-(Dimethylamino)-3,3-bis[4-(dimethylamino)phenyl]phthalide
4-dimethylaminophenyl-6-dimethylaminophthalide
3,3-Bis-4-Dimethylaminophenyl7-6-Dimethylaminophthalide
CVL 3,3-BIS-4-DIMETHYLAMINOPHENYL7-6-DIMETHYLAMINOPHTHALIDE
1(3H)-Isobenzofuranone, 6-(dimethylamino)-3,3-bis4-(dimethylamino)phenyl-
6-Dimethylamino-3,3-bis(4-dimethylaminophenyl)-2-benzofuran-1-one
6-(Dimethylamino)-3,3-bis[4-(dimethylamino)phenyl]isobenzofuran-1(3H)-one
6-Dimethylamino-3,3-bis(p-dimethylaminophenyl)isobenzofuran-1(3H)-one
物理化學(xué)性質(zhì)
安全數(shù)據(jù)
制備方法
![2-[bis[4-(dimethylamino)phenyl]methyl]-5-(dimethylamino)benzoic acid](/CAS/GIF/1255-69-2.gif)
1255-69-2

1552-42-7
實(shí)施例1:向500 mL三口燒瓶中加入21.5 g(純度97.0%)的2-[4,4'-雙(二甲基氨基)二苯甲基]-5-二甲基氨基苯甲酸,隨后加入250 mL去離子水。將所得懸浮液攪拌下加入21.5 g活性炭(型號(hào):SHIRASAGI-C,武田化學(xué)工業(yè)公司生產(chǎn))和2.0 g 49% NaOH水溶液。將反應(yīng)體系加熱至90-95°C并保持此溫度范圍。在反應(yīng)過(guò)程中,以400 mL/min的速率向反應(yīng)體系中通入空氣,持續(xù)9小時(shí)。反應(yīng)完成后,趁熱過(guò)濾反應(yīng)混合物,收集濾餅并用去離子水重新漿化。向漿化液中緩慢加入19.5 g 36% HCl水溶液,直至固體完全溶解。隨后,過(guò)濾除去活性炭。用49% NaOH水溶液調(diào)節(jié)濾液pH至7.0,析出目標(biāo)產(chǎn)物晶體。抽濾收集晶體,用冷水洗滌,真空干燥,得到20.1 g 3,3-雙(4-二甲基氨基苯基)-6-二甲基氨基苯酞,收率95.4%。經(jīng)HPLC分析,副產(chǎn)物生成率為1.5%,反應(yīng)選擇性為98.4%。
參考文獻(xiàn):
[1] Patent: US5973168, 1999, A
[2] Journal of Organic Chemistry USSR (English Translation), 1986, vol. 22, # 10, p. 2012 - 2014
[3] Zhurnal Organicheskoi Khimii, 1986, vol. 22, # 10, p. 2240 - 2241
[4] Patent: US4595768, 1986, A
[5] Patent: US4271075, 1981, A