152-58-9
中文名稱
脫氧可的松
英文名稱
CORTEXOLONE
CAS
152-58-9
EINECS 編號(hào)
205-805-2
分子式
C21H30O4
MDL 編號(hào)
MFCD00003662
分子量
346.46
MOL 文件
152-58-9.mol
更新日期
2025/03/21 09:19:24
152-58-9 結(jié)構(gòu)式
基本信息
中文別名
脫氧皮醇脫氧可的松
可托多松
皮甾酮
腎上腺素皮質(zhì)甾酮
17-羥-11-去氧可體甾酮
17-羥-11-去氧皮甾酮
英文別名
11-DEOXY-17-HYDROXYCORTICOSTERONE11-DEOXYCORTISOL
11-DESOXY-17-HYDROXYCORTICOSTERONE
11-DESOXYCORTISOL
17,21-DIHYDROXY-4-PREGNENE-3,20-DIONE
17,21-DIHYDROXYPROGESTERONE
17ALPHA,21-DIHYDROXY-4-PREGNENE-3,20-DIONE
17ALPHA,21-DIHYDROXYPREGNA-4-ENE-3,20-DIONE
17ALPHA-HYDROXYCORTEXONE
4-PREGNEN-17,21-DIOL-3,20-DIONE
4-PREGNEN-17A 21-DIOL-3,20-DIONE
4-PREGNEN-17ALPHA,21-DIOL-3,20-DIONE
4-PREGNENE-17ALPHA,21-DIOL-3,20-DIONE
(8R,9S,10R,13S,14S,17R)-17-HYDROXY-17-(2-HYDROXY-ACETYL)-10,13-DIMETHYL-1,2,6,7,8,9,10,11,12,13,14,15,16,17-TETRADECAHYDRO-CYCLOPENTA[A]PHENANTHREN-3-ONE
CORTEXOLONE
CORTODOXONE
REICHSTEIN'S COMPOUND ''S''
REICHSTEIN'S SUBSTANCE S
REICHSTEIN'S SUBSTANCE ''S''
REICHSTEIN'S SUBSTANCE 'S'
所屬類別
分析化學(xué)：標(biāo)準(zhǔn)物質(zhì)物理化學(xué)性質(zhì)
熔點(diǎn)205-208 °C
沸點(diǎn)401.19°C (rough estimate)
密度1.22±0.1 g/cm3 (20 ºC 760 Torr)
折射率120 ° (C=1, Dioxane)
閃點(diǎn)9℃
儲(chǔ)存條件Sealed in dry,Room Temperature
溶解度Dioxane (Slightly, Heated, Sonicated), DMSO (Slightly), Methanol (Slightly, Heated)
酸度系數(shù)(pKa)12?+-.0.60(Predicted)
形態(tài)固體
顏色白色至灰白色
水溶解性44.08mg/L(37 ºC)
Merck2932
InChIKeyWHBHBVVOGNECLV-OBQKJFGGSA-N
CAS 數(shù)據(jù)庫152-58-9(CAS DataBase Reference)
安全數(shù)據(jù)
警示詞危險(xiǎn)
危險(xiǎn)性描述H225-H301+H311+H331-H370
危險(xiǎn)品標(biāo)志F,T
危險(xiǎn)類別碼11-23/24/25-39/23/24/25
安全說明S24/25-S22
危險(xiǎn)品運(yùn)輸編號(hào)UN1230 - class 3 - PG 2 - Methanol, solution
WGK Germany3
RTECS號(hào)TU5011500
海關(guān)編碼2937.23.5050
毒性mouse,LD50,intravenous,100mg/kg (100mg/kg),U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. Vol. NX#04684,
常見問題列表
用途
脫氧可的松主要用于生化研究。應(yīng)用
脫氧可的松是一種抗雄激素藥物，局部用于治療痤瘡。它還在開發(fā)更高濃度的藥物，用于治療雄激素依賴性頭皮脫發(fā)。
生物活性
Cortodoxone是一種糖皮質(zhì)類固醇激素，可氧化為皮質(zhì)醇 (Hydrocortisone) 。靶點(diǎn)
|
Human Endogenous Metabolite
|
知名試劑公司產(chǎn)品信息
Acros Organics
脫氧皮醇Cortexolone, 99%(152-58-9)
Sigma Aldrich
152-58-9(sigmaaldrich)TCI Shanghai
脫氧可的松Cortexolone,>98.0%(LC)(152-58-9)