1476-52-4
中文名稱
羥基氯喹EP雜質(zhì)D-d5二鹽酸
英文名稱
DESETHYL CHLOROQUINE
CAS
1476-52-4
分子式
C16H22ClN3
分子量
291.82
MOL 文件
1476-52-4.mol
更新日期
2025/01/14 09:41:24
1476-52-4 結(jié)構(gòu)式
基本信息
中文別名
脫乙基氯喹去乙基氯喹
羥氯喹雜質(zhì)D
氯喹相關(guān)物質(zhì)D
去乙基哌拉西林
去乙基氯喹-D4
去乙基硫酸羥氯喹
去乙基氯喹HBR
羥基氯喹EP雜質(zhì)D
去乙基羥氯喹HBR
英文別名
WR 29623NSC 13254
Deethylchloroquine
DESETHYL CHLOROQUINE
Chloroquine USP RC D
Monodeethylchloroquine
Monodesethylchloroquine
Desethyl Chloroquine sulfate
Chloroquine Related CoMpound D
Hydroxychloroquine Impurity 9 2HBr
所屬類別
分析化學(xué)：藥典標(biāo)準(zhǔn)品和雜質(zhì)標(biāo)準(zhǔn)品物理化學(xué)性質(zhì)
熔點(diǎn)94-97?C
沸點(diǎn)173-175 °C(Press: 0.05 Torr)
密度1.138±0.06 g/cm3(Predicted)
儲(chǔ)存條件-20°C冷凍
溶解度可溶于氯仿（少量）、二氯甲烷（少量）、乙酸乙酯（少量）
酸度系數(shù)(pKa)10.62±0.19(Predicted)
形態(tài)固體
顏色淡黃色至深黃色
生物來(lái)源synthetic
常見問(wèn)題列表
生物活性
Desethyl chloroquine 是 Chloroquine 的主要去乙基代謝產(chǎn)物。Chloroquine 是一種自噬和 toll-like receptors (TLRs) 的抑制劑。Desethyl chloroquine 具有抗瘧原蟲活性。體外研究
P. falciparum
體內(nèi)研究
Intraperitoneal injections of Chloroquine are administered to wild-type and Huntington's disease (Q175/Q175) mice. LC-MS/MS is used to compare the levels Chloroquine and its metabolites in blood, brain and muscle tissue. Concentrations of Chloroquine are lower (5-15M), but more stable in brain tissue compared to blood or muscle between 4 and 24 hours after the last dose. Levels of the active Chloroquine metabolite Desethyl chloroquine decreased in muscle and blood over the 24 hour post-injection period, while brain Desethyl chloroquine levels are lower and rose slightly over the same time frame.