104746-04-5
中文名稱(chēng)
(S)-10-羥基二氫-5H-二苯并[B,F]氮雜卓-5-甲酰胺
英文名稱(chēng)
S-10-MONOHYDROXY-DIHYDRO-CARBAMAZEPIN
CAS
104746-04-5
分子式
C15H14N2O2
分子量
254.288
MOL 文件
104746-04-5.mol
更新日期
2025/02/08 09:36:51
104746-04-5 結(jié)構(gòu)式
基本信息
中文別名
(S)-10-羥基二氫-5H-二苯并[B,F]氮雜卓-5-甲酰胺 英文別名
(10S)-(S)-Licarbazepine
S-10-MONOHYDROXY-DIHYDRO-CARBAMAZEPIN
(S)-10-Monohydroxydihydrocarbamazepine
(10S)-10,11-DIHYDRO-10-HYDROXY CARBAMAZEPINE
(S)-10-Monohydroxy-dihydro-carbamazepine (Eslicarbazepine)
(S)-10-Hydroxy-10,11-dihydro-5H-dibenzo[b,f]azepin-5-carboxamide
(S)-10-Monohydroxy-10,11-dihydro CarbaMazepine (Eslicarbazepine)
(S)-10-Hydroxy-10,11-dihydro-5H-dibenzo[b,f]azepine-5-carboxaMide
5H-Dibenz[b,f]azepine-5-carboxamide, 10,11-dihydro-10-hydroxy-, (10S)-
所屬類(lèi)別
有機(jī)原料：酰胺類(lèi)化合物物理化學(xué)性質(zhì)
熔點(diǎn)188-190°C
沸點(diǎn)431.3±55.0 °C(Predicted)
密度1.336
儲(chǔ)存條件-20°C冷凍
溶解度可溶于氯仿（輕微、加熱）、甲醇（輕微）、吡啶（輕微）
酸度系數(shù)(pKa)13.75±0.20(Predicted)
形態(tài)固體
顏色白色至淡黃色
InChIInChI=1S/C15H14N2O2/c16-15(19)17-12-7-3-1-5-10(12)9-14(18)11-6-2-4-8-13(11)17/h1-8,14,18H,9H2,(H2,16,19)/t14-/m0/s1
InChIKeyBMPDWHIDQYTSHX-AWEZNQCLSA-N
SMILESN1(C(N)=O)C2=CC=CC=C2[C@@H](O)CC2=CC=CC=C12
常見(jiàn)問(wèn)題列表
生物活性
Eslicarbazepine (BIA 2-194) 是一種口服抗驚厥試劑，可用于局部癲癇的輔助研究。體內(nèi)研究
Eslicarbazepine is an anti-epileptic drug, chemically related to carbamazepine but with a more favorable safety profile. Eslicarbazepine acetate is a prodrug for eslicarbazepine (S-licarbazepine), which is a dual a dual Inhibitor of β-Secretase and voltage-gated sodium channel.