Identification | More | [Name]
(R)-(+)-4-Isopropyl-2-oxazolidinone | [CAS]
95530-58-8 | [Synonyms]
(4R)-4-ISOPROPYL-1,3-OXAZOLIDIN-2-ONE (4R)-(+)-4-ISOPROPYL-2-OXAZOLIDINONE (4R)-(+)-ISOPROPYL-2-OXAZOLIDINONE 4-R-ISOPROPYL-OXAZOLIDIN-2-ONE (R)-(+)-4-ISOPROPYL-2-OXAZOLIDINONE (R)-4-ISOPROPYL-2-OXAZOLIDINONE (R)-(+)-4-ISOPROPYL-2-OXAZOLIDINONE, 99% (99% EE/GLC) (R)-Isopropyloxazolidinone (4R)-(+)-4-Isopropyl-2-oxazolidinone, 99% (99% ee) 2-Oxazolidinone, 4-(1-methylethyl)-, (4R)- (4R)-(+)-4-Isopropyl-2-oxazolidinone, 98+% 4-isopropyl-2-oxazolidinone R-4-Isopropyl-2-oxazolidone (4R)-(+)-4-Isopropyl-2-oxazolidone (4R)-4-Propan-2-yl-1,3-oxazolidin-2-one | [Molecular Formula]
C6H11NO2 | [MDL Number]
MFCD00075172 | [Molecular Weight]
129.16 | [MOL File]
95530-58-8.mol |
Chemical Properties | Back Directory | [Appearance]
white to light yellow crystal powde | [Melting point ]
70-73 °C | [alpha ]
-18 º (c=1, ethanol) | [Boiling point ]
239.22°C (rough estimate) | [density ]
1.04 g/cm3 | [refractive index ]
1.4300 (estimate) | [storage temp. ]
0-6°C | [solubility ]
very faint turbidity in EtOH | [form ]
Crystalline Powder | [pka]
12.72±0.40(Predicted) | [color ]
White | [Optical Rotation]
[α]20/D +17°, c = 6 in ethanol | [Water Solubility ]
Soluble | [Detection Methods]
HPLC(Purity),GC | [BRN ]
5376658 | [InChI]
InChI=1S/C6H11NO2/c1-4(2)5-3-9-6(8)7-5/h4-5H,3H2,1-2H3,(H,7,8)/t5-/m0/s1 | [InChIKey]
YBUPWRYTXGAWJX-YFKPBYRVSA-N | [SMILES]
O1C[C@@H](C(C)C)NC1=O | [CAS DataBase Reference]
95530-58-8(CAS DataBase Reference) |
Safety Data | Back Directory | [Hazard Codes ]
Xi | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S22:Do not breathe dust . S24/25:Avoid contact with skin and eyes . S36:Wear suitable protective clothing . S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice . | [WGK Germany ]
3
| [F ]
3 | [HS Code ]
29349990 |
Hazard Information | Back Directory | [Chemical Properties]
white to light yellow crystal powde | [Uses]
(R)-4-Isopropyloxazolidin-2-one is a biochemical reagent that can be used as a biological material or organic compound for life science related research. | [Synthesis]
To a dry Schlenk tube containing DMSO-d6 (1 mL) and cesium carbonate (33 mg, 0.1 mmol) was added (S)-1a (0.1114 mL, 1 mmol). The reaction mixture was frozen in a liquid nitrogen bath (-196 °C), followed by evacuation to remove air and replacement with CO2 gas. After thawing to 25 °C, a balloon (1 L) containing CO2 was connected to the reaction tube. The reaction system was stirred at 150°C for 24 hours. Upon completion of the reaction, the crude product was analyzed by 1H NMR and the yield was calculated using the internal standard N,N-dimethylformamide as reference. Subsequently, DMSO-d6 was removed by distillation under reduced pressure conditions (6 mmHg, 50 °C).The residue was purified by silica gel column chromatography (eluent: hexane/ethyl acetate, 3:1) to afford the target product (S)-4-isopropyloxazolidin-2-one ((S)-2a) as a white solid in 80% isolated yield (103.3 mg, 0.80 mmol). | [References]
[1] Journal of Organic Chemistry, 2000, vol. 65, # 15, p. 4759 - 4761 [2] Tetrahedron Letters, 2013, vol. 54, # 35, p. 4717 - 4720 |
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