| Identification | More | [Name]
2,4-Dichlorobenzylamine | [CAS]
95-00-1 | [Synonyms]
2,4-dichlorobenzenemethanamine
2,4-DICHLOROBENZYLAMINE
AKOS BBS-00003590
LABOTEST-BB LTBB000655
RARECHEM AL BW 0119
(2,4-Dichlorophenyl)methanamine
2,4-dichloro-benzenemethanamin
Benzylamine, 2,4-dichloro-
2,4-Dichlorobenzylamine,98%
(2,4Ddichlorophenyl)methanamine
o,p-Dichlorobenzylamine | [EINECS(EC#)]
202-382-6 | [Molecular Formula]
C7H7Cl2N | [MDL Number]
MFCD00008109 | [Molecular Weight]
176.04 | [MOL File]
95-00-1.mol |
| Safety Data | Back Directory | [Hazard Codes ]
C,Xi | [Risk Statements ]
R34:Causes burns.
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) .
S24/25:Avoid contact with skin and eyes .
S23:Do not breathe gas/fumes/vapor/spray (appropriate wording to be specified by the manufacturer) . | [RIDADR ]
UN 2735 8/PG 3
| [WGK Germany ]
3
| [F ]
9 | [TSCA ]
Yes | [HazardClass ]
8 | [PackingGroup ]
III | [HS Code ]
29214990 |
| Hazard Information | Back Directory | [Chemical Properties]
clear colourless liquid | [Synthesis]
Benzaldehyde oxime (CAS: 56843-28-8, 0.121 g, 1 mmol) was used as a starting material, mixed with nano Fe3O4 (0.046 g, 0.2 mmol, average particle size of about 70 nm) in a porcelain mortar and pestle and ground. Subsequently, ZrCl4 (0.233 g, 1 mmol) was added and the mixture was continued to be ground to homogeneity at room temperature. The mortar was heated in an oil bath to raise the temperature of the reaction mixture to 75-80°C. At this temperature, NaBH3CN (0.314 g, 5 mmol) was added in batches and the reaction mixture was continuously ground for 15 minutes. Upon completion of the reaction, the reaction was quenched by the addition of H2O (5 mL) and stirred for 5 min. The reaction mixture was extracted with EtOAc (2 x 5 mL), the organic phases were combined and dried with anhydrous Na2SO4. The solvent was removed by concentration under reduced pressure to give the pure 2,4-dichlorobenzenemethanamine liquid product in 93% yield (0.1 g, see Table 2, entry 1). | [References]
[1] Journal of the Chinese Chemical Society, 2005, vol. 52, # 1, p. 109 - 112
[2] Bulletin of the Korean Chemical Society, 2011, vol. 32, # 9, p. 3323 - 3326
[3] Bulletin of the Korean Chemical Society, 2011, vol. 32, # 9, p. 3448 - 3452
[4] Journal of the Iranian Chemical Society, 2015, vol. 12, # 5, p. 873 - 878
[5] Journal of Medicinal Chemistry, 1984, vol. 27, # 9, p. 1111 - 1118 |
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