| Identification | More | [Name]
D-Alanyl-D-alanine | [CAS]
923-16-0 | [Synonyms]
D-ALA-D-ALA
D-ALANYL-D-ALANINE
H-D-ALA-D-ALA-OH
(2R)-2-[[(2R)-2-aminopropanoyl]amino]propanoic acid
(R)-N-(D-Alanyl)-2-methylglycine
D-Ala-D-Ala-OH
N-(D-Alanyl)-D-alanine | [Molecular Formula]
C6H12N2O3 | [MDL Number]
MFCD00066038 | [Molecular Weight]
160.17 | [MOL File]
923-16-0.mol |
| Hazard Information | Back Directory | [Chemical Properties]
White to off-white powder | [Definition]
ChEBI: D-alanyl-D-alanine is a dipeptide comprising D-alanine with a D-alanyl residue attached to the alpha-nitrogen. It is a component of bacterial peptidoglycan and forms an important target for development of antibacterial drugs. It has a role as an Escherichia coli metabolite. It is a tautomer of a D-alanyl-D-alanine zwitterion. | [Biological Activity]
D-Ala-D-Ala is found in the stem termini of peptidoglycan side-chain pentapeptide found in the cell walls of gram positive bacteria. The D-ala-d-ala stem termini is the site of interaction of glycopeptide antibiotics such as vancomycin and teicoplanin. D-ala-D-ala is a substrate used to study kinetics of UDPMurNAc-tripeptide D-alanyl-D-alanine-adding (ligase) enzyme.''D-Ala-D-Alaa terminus moiety of bacterial peptidoglycansis used for affinity chromatography and binding mechanism studies of antibiotics such as teicoplaninristocetinvancomycin. |
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