| Identification | More | [Name]
CHLOROFORM-D | [CAS]
865-49-6 | [Synonyms]
CHLOROFORM-D
CHLOROFORM-D1
DEUTEROCHLOROFORM
TRICHLOROMETHANE-D
Deuterotrichloromethane
Trichloro(2H)methane
trichloro-deuterio-methane
trichlorodeutriomethane
chloroform-D 99.8 atom % D*contains 1% tms
Chloroformdiosotopicpurity
Chloroformdisotopicpuritytetramethylsilane
(2H)chloroform
CHLOROFORM-D, 99.8 ATOM % D, STABILIZEDWITH 0.5 WT. % SILVER FOIL
CHLOROFORM-D >99.5 % WITH 1% (V/V) TMS&
CHLOROFORM-D, 99.8 ATOM % D
CHLOROFORM-D+0.05% TMS (V/V) (AMGEN)
CHLOROFORM-D, "100" (MIN. 99.96 ATOM % D)STABILIZED WITH 0.5 WT. % SILVER WIRE
CHLOROFORM-D 99.8 ATOM% D CONTAINS 0.05% (V/V) TMS
CHLOROFORM, 1000MG, NEAT
CHLOROFORM-D EXTRA (MIN. 99.996 ATOM & | [EINECS(EC#)]
212-742-4 | [Molecular Formula]
CCl3D | [MDL Number]
MFCD00000827 | [Molecular Weight]
120.38 | [MOL File]
865-49-6.mol |
| Chemical Properties | Back Directory | [Appearance]
colourless liquid | [Melting point ]
−64 °C(lit.)
| [Boiling point ]
60.9 °C(lit.)
| [density ]
1.500 g/mL at 25 °C(lit.)
| [vapor pressure ]
211 hPa (20 °C) | [refractive index ]
n20/D 1.444(lit.)
| [Fp ]
62°C | [storage temp. ]
Store at +2°C to +8°C. | [solubility ]
Miscible with organic solvents, ethyl acetate and acetone. | [form ]
Liquid In Prescored Ampoules, (0.75Ml/ampoule) | [color ]
White to beige | [Specific Gravity]
1.505 | [Stability:]
Stable. Incompatible with strong bases, alkali metals, aluminium, magnesium, strong oxidizing agents. | [Water Solubility ]
4.6g/L | [Sensitive ]
Moisture Sensitive | [Detection Methods]
HPLC | [BRN ]
1697633 | [Exposure limits]
ACGIH: TWA 10 ppm
OSHA: Ceiling 50 ppm(240 mg/m3)
NIOSH: IDLH 500 ppm; STEL 2 ppm(9.78 mg/m3) | [InChIKey]
HEDRZPFGACZZDS-MICDWDOJSA-N | [LogP]
1.5-1.6 at 20-23℃ and pH9 | [Surface tension]
72.3mN/m at 998.5mg/L and 20℃ | [CAS DataBase Reference]
865-49-6(CAS DataBase Reference) | [Storage Precautions]
Moisture sensitive;Store under inert gas;Light sensitive | [EPA Substance Registry System]
Chloroform-d (865-49-6) |
| Safety Data | Back Directory | [Hazard Codes ]
Xn,T | [Risk Statements ]
R22:Harmful if swallowed.
R38:Irritating to the skin.
R40:Limited evidence of a carcinogenic effect.
R48/20/22:Harmful: danger of serious damage to health by prolonged exposure through inhalation and if swallowed . | [Safety Statements ]
S36/37:Wear suitable protective clothing and gloves . | [RIDADR ]
UN 1888 6.1/PG 3
| [WGK Germany ]
2
| [HazardClass ]
6.1 | [PackingGroup ]
III | [HS Code ]
28459000 | [Toxicity]
LD50 orally in Rabbit: 695 mg/kg LD50 dermal Rabbit > 3980 mg/kg |
| Questions And Answer | Back Directory | [Water peak]
The position of the water peak in different deuterated reagents is not the same. The water peak of heavy water is about 4.67 ppm. There is a trend that the more water the low field.
Chloroform-D is less soluble with water and the water content is low, so its water peak near 1.59 ppm. Deuterated acetone is about 2.8 ppm and the deuterated dimethylsulfoxide has a water peak of about 3.4 ppm. If water is added to deuterated acetone, the water peak will gradually move to a low field and eventually stop at about 4.7 ppm. | [Application]
Chloroform-d has been employed as solvent in a 1H NMR (Proton Nuclear Magnetic Resonance) spectroscopic study. It has been employed as solvent during the 31PNMR (Phosphorus-31 nuclear magnetic resonance) spectral investigation of triphenyl phosphate and tris(2-chloroethyl) phosphate. It has also been used as the deuterated solvent in the 1H NMR spectral studies of 2-(4-bromobenzyl)-3-hydroxypropanoic acid and 3-hydroxy-2-(4-methoxybenzyl)propanoic acid. It has also been used as the deuterated solvent for the 1HNMR
spectral studies of 3,3′-dihydroxy-4,4′-diamino-biphenyl (HAB) and
2,2′-bis-(3,4-dicarboxy-phenyl) hexafluoropropane dianhydride (6FDA)
polyimide.Chloroform-d has been employed as solvent in a 1H NMR (Proton Nuclear Magnetic Resonance) spectroscopic study. It has been employed as solvent during the 31PNMR (Phosphorus-31 nuclear magnetic resonance) spectral investigation of triphenyl phosphate and tris(2-chloroethyl) phosphate. It has also been used as the deuterated solvent in the 1H NMR spectral studies of 2-(4-bromobenzyl)-3-hydroxypropanoic acid and 3-hydroxy-2-(4-methoxybenzyl)propanoic acid. It has also been used as the deuterated solvent for the 1HNMR
spectral studies of 3,3′-dihydroxy-4,4′-diamino-biphenyl (HAB) and
2,2′-bis-(3,4-dicarboxy-phenyl) hexafluoropropane dianhydride (6FDA)
polyimide. |
| Hazard Information | Back Directory | [Description]
Deuterated chloroform (CDCl3), also known as chloroform-d, is an excellent everyday solvent choice for scientists who demand exceptional results. Commonly used as a solvent in proton NMR (1H NMR) spectroscopy, chloroform-d can dissolve a vast array of compounds with ease due to its weak polarity. It is often used in combination with methanol-d as a cosolvent. Plus, its low boiling point makes it relatively easy to recover a sample post-NMR analysis or during organic syntheses. | [Chemical Properties]
colourless liquid | [Uses]
Labelled Chloroform, generally in trimethylsilane solution, used in NMR spectroscopy as a solvent. Unlabelled chloroform has been used an an anaesthetic due to its action on the central nervous system
. | [Definition]
ChEBI: A deuterated compound that is is an isotopologue of chloroform in which the hydrogen atom is replaced with a deuterium. Commonly used as a solvent in proton MNR spectroscopy. | [General Description]
Chloroform-d (Deuterochloroform, CDCl3), deuterated chloroform, is a 100% isotopically enriched NMR (Nuclear Magnetic Resonance) solvent. It is widely employed in high resolution NMR studies due to its high chemical and isotopic purity. Quantitaive infrared spectral investigations of carbon-deuterium stretching bands of chloroform-d in various organic solvents have been reported. Raman difference spectroscopic studies of mixtures of chloroform-d and liquid chloroform have been conducted to evaluate frequency shifts in the in the ν1 and ν2 bands of CHCl3 and CDCl3. |
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