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ChemicalBook--->CAS DataBase List--->781661-94-7

781661-94-7

781661-94-7 Structure

781661-94-7 Structure
IdentificationMore
[Name]

YM155 (Sepantronium Bromide)
[CAS]

781661-94-7
[Synonyms]

YM155
SepantroniuM broMide
YM155 (SepantroniuM BroMide)
Sepantronium Bromide (YM155)
SepantroniuM broMide(YM155,YM-155)
4,9-Dihydro-1-(2-methoxyethyl)-2-methyl-4,9-dioxo-3-(2-pyrazinylmethyl)-1H-naphth[2,3-d]imidazolium bromide
1H-Naphth[2,3-d]imidazolium, 4,9-dihydro-1-(2-methoxyethyl)-2-methyl-4,9-dioxo-3-(2-pyrazinylmethyl)-, bromide (1:1)
YM 155 4,9-Dihydro-1-(2-methoxyethyl)-2-methyl-4,9-dioxo-3-(2-pyrazinylmethyl)-1H-naphth[2,3-d]imidazolium bromide
4,9-Dihydro-1-(2-methoxyethyl)-2-methyl-4,9-dioxo-3-(2-pyrazinylmethyl)-1H-naphth[2,3-d]imidazolium bromide YM 155
[Molecular Formula]

C20H19BrN4O3
[MDL Number]

MFCD11983133
[MOL File]

781661-94-7.mol
[Molecular Weight]

443.294
Chemical PropertiesBack Directory
[Melting point ]

>180°C (dec.)
[storage temp. ]

-20°
[solubility ]

Soluble in DMSO (up to 25 mg/ml).
[form ]

solid
[color ]

Tan to yellow
[Stability:]

Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
Hazard InformationBack Directory
[Usage]

YM155 is a novel small-molecule survivin suppressant that suppressed expression of survivin and induced apoptosis in PC-3 and PPC-1 human HRPC cell lines.
[Usage]

YM155 is a potent IAP (inhibitor of apoptosis proteins) inhibitor for survivin with IC50 of 0.54 nM.
[Description]

YM-155 (781661-94-7) is a novel small molecule survivin suppressant. YM-155 suppresses expression of survivin (a member of the IAP family) and induced apoptosis in human tumor cell lines at 10 nmol/L with little effect on other IAP or Bcl-2 family members.1?Overcomes erlotinib resistance in EGFR mutation-positive non-small cell lung cancer.2?Induces DNA damage.3?YM-155 induces an autophagy-dependent cell death in adenoid cystic carcinoma cells.4
[Uses]

YM155 is a novel small-molecule survivin suppressant that suppressed expression of survivin and induced apoptosis in PC-3 and PPC-1 human HRPC cell lines.
[Uses]

YM155 is a novel small-molecule survivin suppressant that suppressed expression of survivin and induced apoptosis in PC-3 and PPC-1 human HRPC. cell lines. Potent Survivin Inhibitor.
[Uses]

YM155 is a potent IAP (inhibitor of apoptosis proteins) inhibitor for survivin with IC50 of 0.54 nM.
[Definition]

ChEBI: Sepantronium bromide is an organic bromide salt consisting of sepantronium cations and bromide anions. It has been found to selectively inhibit survivin (BIRC5) gene promoter activity and to down-regulate survivin in vitro, so leading to induction of apoptosis. It has a role as an antineoplastic agent, a survivin suppressant and an apoptosis inducer. It contains a sepantronium.
[target]

Survivin
[storage]

Store at -20°C
[References]

1) Nakahara?et al. (2007),?YM155, a novel small-molecule surviving suppressant, induces regression of established human hormone-refractory prostate tumor xenografts; Cancer Res.?67?8014 2) Okamoto?et al. (2012),?Overcoming erlotinib resistance in EGFR mutation-positive non-small cell lung cancer cells by targeting survivin; Mol.Cancer Ther.?11?204 3) Glaros?et al. (2012),?The ‘survivin suppressants’ NSC 80467 and YM 155 induce a DNA damage response; Cancer Chemother. Pharmacol.?70?207 4) Wang?et al. (2014),?Induction of autophagy-dependent cell death by the survivin suppressant YM155 in salivary adenoid cystic carcinoma; Apoptosis?19?748
Safety DataBack Directory
[HS Code ]

29339900
Spectrum DetailBack Directory
[Spectrum Detail]

YM155(781661-94-7)1HNMR
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