| Identification | More | [Name]
4-(CHLOROMETHYL)THIAZOLE HYDROCHLORIDE | [CAS]
7709-58-2 | [Synonyms]
4-(CHLOROMETHYL)-1,3-THIAZOLE
4-(CHLOROMETHYL)-1,3-THIAZOLE HYDROCHLORIDE
4-CHLOROMETHYL-THIAZOLE
4-(CHLOROMETHYL)THIAZOLE HCL
4-(CHLOROMETHYL)THIAZOLE HYDROCHLORIDE
CHLOROMETHYLTHIAZOLE-4 HCL
chloromethylthiazolehydrochloride | [EINECS(EC#)]
672-064-3 | [Molecular Formula]
C4H5Cl2NS | [MDL Number]
MFCD02094738 | [Molecular Weight]
170.06 | [MOL File]
7709-58-2.mol |
| Safety Data | Back Directory | [Hazard Codes ]
Xi | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection . | [WGK Germany ]
3 | [HazardClass ]
IRRITANT | [HS Code ]
2934100090 |
| Hazard Information | Back Directory | [Chemical Properties]
White crystalline | [Uses]
4-(Chloromethyl)thiazole hydrochloride and its derivatives can be used to prepare 4-thiazole carboxylic acid. It has been shown that in the study of synthesis of conformationally restricted RGD-containing integrin ligands by efficient solid-phase intramolecular thioalkylation, the reaction of S-nucleophiles with the newly generated N-terminal 4-chloromethyl thiazoles afforded the desired cyclic RGD product 5 with high purity and good overall yield[1]. | [References]
[1] ADEL NEFZI Jason E F. N-terminus 4-chloromethyl thiazole peptide as a macrocyclization tool in the synthesis of cyclic peptides: application to the synthesis of conformationally constrained RGD-containing integrin ligands[J]. Tetrahedron Letters, 2011. DOI:10.1016/j.tetlet.2010.12.043. |
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