| Identification | More | [Name]
Dextromethorphan hydrobromide monohydrate | [CAS]
6700-34-1 | [Synonyms]
D-3-METHOXY-N-METHYLMORPHINAN HYDROBROMIDE
DEXTROMETHORPHAN HYDROBROMIDE
DEXTROMETHORPHAN HYDROBROMIDE MONOHYDRATE
dextromethorphansigmareference*standard
DMHM
DEXTROMETHORPHAN HYDROBROMIDE, PH EUR
DEXTROMETHORPHAN HYDROBROMIDE*MONOHYDRAT E USP
D-Methorphan hydrobromide monohydrate
Morphinan, 3-methoxy-17-methyl-, hydrobromide, monohydrate, (9.alpha.,13.alpha.,14.alpha.)-
Dextromethorphan monohydrate hydrobromide, (9S,13S,14S)-3-Methoxy-17-methylmorphinan hydrobromide
Dextromethorphan hydrobromicum, (9S,13S,14S)-3-Methoxy-17-methylmorphinan hydrobromide
Dextromethorphan monohydrate hydrobromide | [EINECS(EC#)]
629-741-3 | [Molecular Formula]
C18H28BrNO2 | [MDL Number]
MFCD02173901 | [Molecular Weight]
370.32 | [MOL File]
6700-34-1.mol |
| Chemical Properties | Back Directory | [Appearance]
White Solid | [Melting point ]
116-119°C | [alpha ]
[α]D25 +26～+30° (c=1.85, H2O) | [Fp ]
11 °C | [storage temp. ]
Store at RT | [solubility ]
Sparingly soluble in water, freely soluble in ethanol (96 per cent). | [form ]
solid | [color ]
White to Off-White | [PH]
pH (10g/l, 25℃) : 5.2～6.5 | [Usage]
An antitussive drug | [BRN ]
6453793 | [InChIKey]
QYPSYPPSHXDFLV-UHFFFAOYSA-N | [LogP]
1.351 (est) | [CAS DataBase Reference]
6700-34-1(CAS DataBase Reference) |
| Hazard Information | Back Directory | [Description]
Dextromethorphan (DXM) is a dextratrorotatory morphinan with structural similarity to levorphanol, codeine, and morphine. Because of its strong antitussive effects, dextromethorphan is widely used as a cough suppressant.1 However, it does not provoke opioid activity as is characteristic of several other morphine derivatives. DXM binds to and inhibits NMDA (IC50 = 0.55 μM) and nicotinic receptors (IC50s = 0.7-3.9 μM) and blocks receptor-gated and voltage-gated calcium channels (IC50 = 60 μM) and voltage-gated sodium channels (IC50 = 78 μM).1,2,3 DXM has been used in multimodal analgesic therapies for acute and neuropathic pain.1,4 | [Chemical Properties]
White Solid | [Uses]
An antitussive drug. Orally active synthetic morphine analog. Analgesic (narcotic). Racemethorphan and levomethorpham are controlled substances (opiates). | [Uses]
Antitussive;Opioid ligand | [Definition]
ChEBI: Dextromethorphan hydrobromide is the hydrobromide and monohydrate of the antitussive drug dextromethorphan. It is a hydrate and a hydrobromide. It contains a dextromethorphan. | [Brand name]
Benylin DM
(Parke-Davis); Dextromethorphan Hydrobromide OROS
Tablets (Ciba-Geigy); Drixoral Cough (Schering-Plough HealthCare); PediaCare 1 (McNeil Consumer); Romilar
(Hoffmann-LaRoche-International); St. Joseph Cough Syrup
(Schering-Plough HealthCare). | [Biological Activity]
Non-competitive, low affinity NMDA receptor antagonist. Antitussive, anticonvulsive and neuroprotective agent. | [Toxics Screening Level]
The Initial Threshold Screening Level (ITSL) is 0.4 μg/m3 annual average. |
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