| Identification | More | [Name]
2,3-Difluorophenol | [CAS]
6418-38-8 | [Synonyms]
2,3-DIFLUOROPHENOL
PHENOL, 2,3-DIFLUORO-
2,3-Difluorophenol,98+%
2,3-Difluorophenole
2,3-Difluorophenol 98% | [EINECS(EC#)]
264-750-2 | [Molecular Formula]
C6H4F2O | [MDL Number]
MFCD00010262 | [Molecular Weight]
130.09 | [MOL File]
6418-38-8.mol |
| Chemical Properties | Back Directory | [Appearance]
white crystalline low melting mass | [Melting point ]
39-42 °C (lit.) | [Boiling point ]
54 °C/25 mmHg (lit.) | [density ]
1.2483 (estimate) | [Fp ]
134 °F
| [storage temp. ]
Flammables area | [form ]
powder to lump to clear liquid | [pka]
7.71±0.10(Predicted) | [color ]
White or Colorless to Almost white or Almost colorless | [Usage]
Intermediates of Liquid Crystals | [BRN ]
2082265 | [InChI]
InChI=1S/C6H4F2O/c7-4-2-1-3-5(9)6(4)8/h1-3,9H | [InChIKey]
RPEPGIOVXBBUMJ-UHFFFAOYSA-N | [SMILES]
C1(O)=CC=CC(F)=C1F | [CAS DataBase Reference]
6418-38-8(CAS DataBase Reference) |
| Safety Data | Back Directory | [Hazard Codes ]
F,Xn,Xi,C | [Risk Statements ]
R11:Highly Flammable.
R22:Harmful if swallowed.
R36/37/38:Irritating to eyes, respiratory system and skin .
R34:Causes burns.
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection .
S16:Keep away from sources of ignition-No smoking . | [RIDADR ]
UN 1325 4.1/PG 2
| [WGK Germany ]
3
| [Hazard Note ]
Irritant | [HazardClass ]
4.1 | [PackingGroup ]
III | [HS Code ]
29081900 |
| Hazard Information | Back Directory | [Chemical Properties]
white crystalline low melting mass | [Uses]
Intermediates of Liquid Crystals | [Application]
2,3-Difluorophenol was used in the synthesis of material-poly{methyl[3-(2-hydroxy-3,4-difluoro)phenyl]propyl siloxane} (PMDFPS) sensitive to toxic organophosphate. | [Synthesis]
Step 1: In a 500 mL round-bottomed flask, dissolve 2,3-difluorophenylboronic acid (30 g, 189.98 mmol, 1.00 eq.) in dichloromethane (250 mL). Hydrogen peroxide (30 mL) was added slowly and dropwise under stirring conditions. The reaction mixture was stirred continuously at 25°C for 2 hours. Upon completion of the reaction, the reaction mixture was washed sequentially with water and saturated saline, the organic phase was dried over anhydrous magnesium sulfate, and subsequently concentrated under reduced pressure to afford 2,3-difluorophenol 23 g (93% yield) as a brown oil. | [References]
[1] K.P. RAJAPPAN NAIR . Supersonic jet microwave rotational spectrum of 2,3-difluorophenol[J]. Journal of Molecular Structure, 2019, 1195: Pages 479-484. DOI:10.1016/j.molstruc.2019.06.004.
[2] WEI HE . Analytical application of poly{methyl[3-(2-hydroxy-3,4-difluoro)phenyl]propyl siloxane} as a QCM coating for DMMP detection[J]. Talanta, 2008, 76 3: Pages 698-702. DOI:10.1016/j.talanta.2008.04.022.
[3] E. MARZI M. S J Gorecka. The regioexhaustive functionalization of difluorophenols and trifluorophenols through organometallic intermediates[J]. Synthesis-Stuttgart, 2004, 441 1: 1609-1618. DOI:10.1055/S-2004-829110. |
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