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ChemicalBook--->CAS DataBase List--->630-93-3

630-93-3

630-93-3 Structure

630-93-3 Structure
IdentificationMore
[Name]

Phenytoin sodium
[CAS]

630-93-3
[Synonyms]

5,5-diphenyl-2,4-imidazolidinedione monosodium salt
5,5-DIPHENYL-2,4-IMIDAZOLIDINEDIONE SODIUM SALT
5,5-DIPHENYLHYDANTOIN SODIUM
5,5-DIPHENYLHYDANTOIN SODIUM SALT
DILANTIN
DIPHENYLHYDANTOIN SODIUM SALT
PHENYLTOIN SODIUM
PHENYTOIN SODIUM
PHENYTOIN SODIUM SALT
sodium 5,5-diphenyl-2,4-imidazolidinedione
SODIUM 5,5-DIPHENYLHYDANTOIN
SODIUM DIPHENYLHYDANTOIN
4-imidazolidinedione,5,5-diphenyl-monosodiumsalt
5,5-diphenyl-hydantoimonosodiumsalt
5,5-diphenylhydantoinsodiumsigmaultra
5,5-diphenyl-hydantoisodiumsalt
alepsin
aleviatinsodium
auranile
denylsodium
[EINECS(EC#)]

211-148-2
[Molecular Formula]

C15H12N2NaO2
[MDL Number]

MFCD00069674
[Molecular Weight]

275.26
[MOL File]

630-93-3.mol
Chemical PropertiesBack Directory
[Appearance]

White or almost white, crystalline powder, slightly hygroscopic.
[storage temp. ]

Inert atmosphere,Room Temperature
[solubility ]

aqueous base: soluble
[form ]

Crystalline Powder
[color ]

White to almost white
[Merck ]

7322
[BCS Class]

2
[Stability:]

Hygroscopic
[InChI]

InChI=1S/C15H12N2O2.Na.H/c18-13-15(17-14(19)16-13,11-7-3-1-4-8-11)12-9-5-2-6-10-12;;/h1-10H,(H2,16,17,18,19);;
[InChIKey]

FJPYVLNWWICYDW-UHFFFAOYSA-M
[SMILES]

O=C1NC(=O)NC1(C1C=CC=CC=1)C1C=CC=CC=1.[NaH]
[CAS DataBase Reference]

630-93-3(CAS DataBase Reference)
[EPA Substance Registry System]

630-93-3(EPA Substance)
Safety DataBack Directory
[Hazard Codes ]

Xn
[Risk Statements ]

R22:Harmful if swallowed.
R43:May cause sensitization by skin contact.
R62:Possible risk of impaired fertility.
R63:Possible risk of harm to the unborn child.
[Safety Statements ]

S22:Do not breathe dust .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) .
[RIDADR ]

UN 2811 6.1/PG 3
[WGK Germany ]

3
[RTECS ]

MU1400000
[HazardClass ]

6.1(b)
[PackingGroup ]

III
[HS Code ]

29332100
[Safety Profile]

Confirmed carcinogen. Experimental teratogen. Other experimental reproductive effects. Poison by ingestion, subcutaneous, intravenous, and intraperitoneal routes. Human systemic effects by ingestion: anorexia, respiratory depression, nausea or vomiting, hemorrhage, dermatitis, and endocrine effects. Mutation data reported. An anticonvulsant and cardiac depressant used for the treatment of grand mal and psychomotor seizures. When heated to decomposition it emits very toxic fumes of NOx and Na2O.
[Toxicity]

LD50 orally in mice: 490 mg/kg (Fink, Swinyard)
Raw materials And Preparation ProductsBack Directory
[Raw materials]

Benzil-->5,5-Diphenylhydantoin-->Sodium hydroxide-->Sodium chloride
Material Safety Data Sheet(MSDS)Back Directory
[msds information]

5,5-Diphenylhydantoin sodium salt(630-93-3).msds
Hazard InformationBack Directory
[Chemical Properties]

White or almost white, crystalline powder, slightly hygroscopic.
[Uses]

antibacterial
[Uses]

Antiepileptic
[Brand name]

Diphenylan (Lannett); Phenytek (Mylan); Phenytex (Watson) [Name previously used: Diphenylhydantoin Sodium.].
[General Description]

Phenytoin sodium, 5,5-diphenyl-2,4-imidazolidinedione, 5,5-diphenylhydantoin,diphenyl-hydantoin sodium (Dilantin), has been used fordecades in the control of grand mal types of epilepticseizure. It is structurally analogous to the barbiturates butdoes not possess their extensive sedative properties. Thecompound is available as the sodium salt. Solutions for parenteraladministration contain 40% propylene glycol and10% alcohol to dissolve the sodium salt.
[Biological Activity]

Reduces incidence of grand mal seizures; appears to stabilize excitable membranes perhaps through effects on Na+K+and Ca2+ channels.
[Clinical Use]

Phenytoin sodium’s cardiovascular effects were uncoveredduring observation of toxic manifestations of the drugin patients being treated for seizure disorders. Phenytoinsodium was found to cause bradycardia, prolong the PRinterval, and produce T-wave abnormalities on electrocardiograms.It is a class IB antiarrhythmic agent. Today,phenytoin sodium’s greatest clinical use as an antiarrhythmicdrug is in the treatment of digitalis-induced arrhythmias.34 Its action is similar to that of lidocaine. It depressesventricular automaticity produced by digitalis, without adverseintraventricular conduction. Because it also reversesthe prolongation of AV conduction by digitalis, phenytoinsodium is useful in supraventricular tachycardias caused bydigitalis intoxication.
[Synthesis]

5,5-Diphenylhydantoin

57-41-0

Phenytoin sodium

630-93-3

Example 2: General procedure for the synthesis of 2,4-dioxo-5,5-diphenylimidazoline-1-sodium salt from 5,5-diphenylglycolide urea: 5,5-diphenylglycolide urea (20 g) was dissolved in 120 mL of deionized water and sodium hydroxide solution (3.56 g in 22.5 mL of water), and stirred in a 250 mL four-necked round-bottomed flask at 25-30 °C until complete dissolution. The reaction mixture was filtered. The reaction mixture was filtered, the clarified filtrate was collected and sodium chloride solution (4 g in 10 mL of water) was added to it. The reaction mixture was cooled to 5-10 °C under nitrogen protection and stirred for 60 min. The solid product was filtered under vacuum and washed with 20 mL of cold water. The solid was dried under nitrogen atmosphere at 50-60°C to give 18.5 g of dry 2,4-dioxo-5,5-diphenylimidazoline-1- sodium salt in about 85% yield. Example 3: 5,5-Diphenylglycolide (25 g) was dissolved in 150 mL of deionized water and sodium hydroxide solution (4.45 g in 25 mL of water) in a 250 mL four-necked round-bottomed flask with stirring at 25-30 °C until completely dissolved. The reaction mixture was filtered, the clarified filtrate was collected and sodium chloride solution (7.5 g in 22 mL of water) was added to it. The reaction mixture was cooled to 5-10°C under nitrogen protection and stirred for 60 minutes. The solid product was filtered under vacuum and washed with 20 mL of cold water. The solid was dried under nitrogen atmosphere at 50-60°C to give 25.3 g of dry 2,4-dioxo-5,5-diphenylimidazoline-1- sodium salt in about 93% yield. Example 4: 5,5-Diphenylglycolide (25 g) was dissolved in 150 mL of deionized water and sodium hydroxide solution (4.45 g in 25 mL of water) in a 250 mL four-necked round-bottomed flask with stirring at 25-30 °C until completely dissolved. The reaction mixture was filtered, the clarified filtrate was collected and sodium chloride solution (10 g in 28 mL of water) was added to it. The reaction mixture was cooled to 5-10°C under nitrogen protection and stirred for 60 minutes. The solid product was filtered under vacuum and washed with 20 mL of cold water. The solid was dried under nitrogen atmosphere at 50-60°C to give 25.9 g of dry 2,4-dioxo-5,5-diphenylimidazoline-1- sodium salt in about 95.3% yield. Example 5: Potassium hydroxide (152 g) was dissolved in 96 mL of deionized water in a 3L round-bottomed flask, methanol (480 mL) was added at 25-30°C and cooled to 0-5°C. The mixture was then purified by addition of urea. Urea (49.5 g) and diphenylethylenedione (100 g) were added at 0-5 °C. The reaction mixture was refluxed for 60 min. The reaction mixture was refluxed for 60 min, 144.0 mL of water was added and cooled to 0 °C. The reaction mixture was then cooled to 0 °C. 10 g of diatomaceous earth and 10 g of activated carbon were added and stirred at 0-5 °C for 30-60 min. The reaction mixture was filtered through a bed of diatomaceous earth, washed with cooled 100 mL of water, and the filtrate was collected in a 3L round bottom flask. The pH was adjusted to 6.0-7.0 with concentrated hydrochloric acid at 30-45 °C. The slurry was stirred for 30 min, filtered and washed with 1000 mL of hot water to give 178.1 g of wet 5,5-diphenylglycolide with a moisture content of 38.7% and an anhydrous weight of 109.2 g. Wet 5,5-diphenylglycolide (178 g) was dissolved in 600 mL of deionized water and a solution of sodium hydroxide ( 16.7 g was dissolved in 105 mL of water) in a 2L round-bottomed flask and stirred at 30-40 °C until complete dissolution. The reaction mixture was filtered, the clarified filtrate was collected and sodium chloride solution (2 g in 32 mL of water) was added to it. The filtrate was cooled to 5-10°C under nitrogen protection and stirred for 60 minutes. The solid product was filtered under vacuum and washed with 100 mL of cold water. The solid was dried under nitrogen atmosphere at 50-60°C to give 102.6 g of dry 2,4-dioxo-5,5-diphenylimidazoline-1- sodium salt.

[Carcinogenicity]

Phenytoin and its sodium salt are reasonably anticipated to be human carcinogens based on sufficient evidence from studies in experimental animals.
[Solubility in water]

1 g dissolves in ca. 66 ml of water. The aqueous solution is turbid unless the pH is adjusted above 11.7, which is the pH of the saturated solution. 1 g dissolves in 10.5 mL of alcohol. Practically insoluble in ether and chloroform.
[storage]

Store at RT
[Toxics Screening Level]

The IRSL for Dilantin is 0.07 μg/m3.
[References]

[1] Patent: WO2007/129184, 2007, A2. Location in patent: Page/Page column 3-6
[2] Patent: WO2007/129184, 2007, A2. Location in patent: Page/Page column 4
Spectrum DetailBack Directory
[Spectrum Detail]

Phenytoin sodium(630-93-3)1HNMR
Phenytoin sodium(630-93-3)IR1
Phenytoin sodium(630-93-3)IR2
Well-known Reagent Company Product InformationBack Directory
[Sigma Aldrich]

630-93-3(sigmaaldrich)
[TCI AMERICA]

5,5-Diphenylhydantoin Sodium Salt,>98.0%(T)(630-93-3)
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