| Identification | More | [Name]
Sodium formaldehydesulfoxylate dihydrate | [CAS]
6035-47-8 | [Synonyms]
FORMALDEHYDE SODIUM SULFOXYLATE
FORMALDEHYDE SULFOXYLATE SODIUM
FORMALDEHYDE SULFOXYLATE SODIUM DIHYDRATE
HYDROXYMETHANESULFINIC ACID, MONOSODIUM SALT DIHYDRATE
HYDROXYMETHANESULFINIC ACID SODIUM SALT
HYDROXYMETHANESULFINIC ACID SODIUM SALT DIHYDRATE
RONGALIT
RONGALITE
RONGALITE C
RONGALITE DIHYDRATE
RONGALITE(TM)
RONGALIT(R) DIHYDRATE
SODIUM FORMALDEHYDESULFOXALATE
SODIUM FORMALDEHYDE SULFOXYLATE
SODIUM FORMALDEHYDESULFOXYLATE DIHYDRATE
SODIUM HYDROXYMETHANESULFINATE
SODIUM HYDROXYMETHANESULFINATE DIHYDRATE
SODIUM HYDROXYMETHYLSULFINATE
SODIUM SULFOXYLATE FORMALDEHYDE
Methanesulfinicacid,hydroxy-,monosodiumsalt,dihydrate | [EINECS(EC#)]
205-739-4 | [Molecular Formula]
CH6Na2O5S | [MDL Number]
MFCD00040426 | [Molecular Weight]
176.1 | [MOL File]
6035-47-8.mol |
| Chemical Properties | Back Directory | [Appearance]
white crystalline powder | [Melting point ]
64-68 °C(lit.) | [bulk density]
950kg/m3 | [density ]
1.8 g/cm3 (20℃) | [vapor pressure ]
2.68 hPa (20 °C) | [storage temp. ]
Store below +30°C. | [solubility ]
alcohol: slightly soluble(lit.) | [form ]
powder to crystal | [color ]
White to Almost white | [PH]
9.5-10.5 (100g/l, H2O, 20℃) | [Water Solubility ]
H2O: 50mg/mL, clear, colorless | [CAS DataBase Reference]
6035-47-8(CAS DataBase Reference) |
| Safety Data | Back Directory | [Hazard Codes ]
Xn | [Risk Statements ]
31-68 | [Safety Statements ]
S24/25:Avoid contact with skin and eyes . | [WGK Germany ]
3
| [RTECS ]
PB0390000
| [HS Code ]
28311000 | [Toxicity]
LD50 orally in Rabbit: 6400 mg/kg |
| Hazard Information | Back Directory | [Chemical Properties]
When freshly prepared, sodium formaldehyde sulfoxylate occurs as
white, odorless crystals, which quickly develop a characteristic
garlic odor on standing. | [Chemical Properties]
white crystalline powder | [Uses]
Sodium hydroxymethanesulfinate dihydrate is a versatile reagent that can be used for a wide range of organic transformations such as:
- A SO2-2anion source for the preparation of sulfones and sultines.
- Debromination of vicinal dibromoalkanes.
- Reductive dehalogenation of aldehydes and ketones.
| [Uses]
Pharmaceutic aid (preservative). | [Production Methods]
Sodium formaldehyde sulfoxylate is manufactured from sodium
dithionate and formaldehyde in water. | [General Description]
Oxidation reation of hydroxymethanesulfinic acid with chlorite has been studied in the pH range 4-8. It is a sulfur-containing reducing agent. | [Pharmaceutical Applications]
Sodium formaldehyde sulfoxylate is a water-soluble antioxidant
and is generally used as the dihydrate. It is used in the formulation
of injection products at a level of up to 0.1% w/v in the final
preparation administered to the patient. | [Safety]
The toxicological properties of sodium formaldehyde sulfoxylate
have not been fully investigated. However, it is used in the
formulation of injection products at a level to 0.1% w/v in the
final preparation administered to the patient.
Sodium formaldehyde sulfoxylate is moderately toxic by
ingestion, and when heated to decomposition it emits toxic fumes
of sulfur dioxide and sodium oxide.
LD50 (mouse, oral): 4 g/kg
LD50 (rat, IP): >2 g/kg
LD50 (rat, oral): >2 g/kg | [storage]
Store in well-closed, light-resistant containers at controlled room
temperature (15–30℃). | [Incompatibilities]
Sodium formaldehyde sulfoxylate is incompatible with strong
oxidizing agents; it is decomposed by dilute acid. | [Regulatory Status]
Included in the FDA Inactive Ingredients Database (parenteral
products up to 0.1% via the IM, IV, and SC routes). Included in the
Canadian List of Acceptable Non-medicinal Ingredients. |
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