| Identification | More | [Name]
tert-Butyl 1-piperazinecarboxylate | [CAS]
57260-71-6 | [Synonyms]
1-BOC-PIPERAZINE
1-N-BOC-PIPERAZINE
1-(TERT-BUTOXYCARBONYL)PIPERAZINE
BOC-PAZ
BOC-PIPERAZINE
BUTTPARK 52\11-35
N-BOC-PIPERAZINE
N-(T-BOC)PIPERAZINE
N-T-BUTOXYCARBONYLPIPERAZINE
N-(TERT-BUTOXYCARBONYL)PIPERAZINE
N-(TERT-BUTYLOXYCARBONYL)-PIPERAZINE
PIBOC
PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
RARECHEM AR PA 0026
TERT-BUTYL 1-PIPERAZINECARBOXYLATE
TERT-BUTYL N-PIPERAZINE
TERT-BUTYL PIPERAZINE-1-CARBOXYLATE
TERT-BUTYL TETRAHYDROPYRAZINE-1(2H)-CARBOXYLATE
t-Butyl 1-piperazincarboxylate
1-(tert-Butoxycarbonyl)piperazine~tert-Butyl 1-piperazinecarboxylate | [EINECS(EC#)]
611-489-0 | [Molecular Formula]
C9H18N2O2 | [MDL Number]
MFCD00075265 | [Molecular Weight]
186.25 | [MOL File]
57260-71-6.mol |
| Chemical Properties | Back Directory | [Appearance]
Waxy Solid | [Melting point ]
43-47 °C(lit.)
| [Boiling point ]
98-100 | [density ]
1.030±0.06 g/cm3(Predicted) | [Fp ]
>230 °F
| [storage temp. ]
Keep in dark place,Inert atmosphere,2-8°C | [solubility ]
Soluble in DMSO | [form ]
Low Melting Crystalline Mass | [pka]
8.45±0.10(Predicted) | [color ]
White to light yellow | [Water Solubility ]
Soluble in ethyl acetate, methanol and water. | [Sensitive ]
Air Sensitive | [Detection Methods]
MS,NMR,HPLC | [BRN ]
879985 | [InChIKey]
CWXPZXBSDSIRCS-UHFFFAOYSA-N | [CAS DataBase Reference]
57260-71-6(CAS DataBase Reference) | [NIST Chemistry Reference]
T-butyl 1-piperaziencarboxylate(57260-71-6) |
| Safety Data | Back Directory | [Hazard Codes ]
Xi | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36:Wear suitable protective clothing . | [RIDADR ]
3263 | [WGK Germany ]
3
| [F ]
3-10-34 | [Hazard Note ]
Irritant | [HazardClass ]
IRRITANT | [HS Code ]
29335900 |
| Hazard Information | Back Directory | [Chemical Properties]
Waxy Solid | [Application]
Tert-Butyl 1-piperazinecarboxylate, also known as Olaparib Impurity 7, is an impurity of Olaparib. Olaparib is used alone or in combination with bevacizumab (Avastin) to help maintain the response of certain types of ovarian (female reproductive organs where eggs are formed), fallopian tube (tube that transports eggs released by the ovaries to the uterus), and peritoneal (layer of tissue that lines the abdomen) cancer in people who have completely responded or partially responded to their first or later chemotherapy treatments. Olaparib is also used to treat certain types of breast cancer that has spread to other parts of the body and has not improved or has worsened after treatment with other therapies. It is also used to treat certain types of early breast cancer in people who have already been treated with other chemotherapy treatments. | [General Description]
1-Boc-piperazine is an N-Boc protected piperazine. Crosscoupling of 1-Boc-piperazine with aryl iodides using CuBr/1,1′-bi-2-naphthol (catalyst) and K3PO4 (base) has been reported. 1-Boc-piperazine undergoes Buchwald-Hartwig coupling reactions with aryl halides. 1-Boc-piperazine can be prepared in 80% yield via solvent-free N-Boc protection catalyzed by iodine. |
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