Identification | More | [Name]
2,3-Dihydrobenzo[b]furan-5-carbaldehyde | [CAS]
55745-70-5 | [Synonyms]
2,3-DIBENZO[B]FURAN-5-CARBOXALDEHYDE 2,3-DIHYDRO-1-BENZOFURAN-5-CARBALDEHYDE 2,3-DIHYDROBENZO[B]FURAN-5-CARBALDEHYDE 2,3-DIHYDROBENZO[B]FURAN-5-CARBOXALDEHYDE 2,3-DIHYDROBENZOFURAN-5-CARBALDEHYDE 2,3-DIHYDROBENZOFURAN-5-CARBOXALDEHYDE AKOS MSC-0772 BUTTPARK 27\04-60 TIMTEC-BB SBB005559 2,3-dihyro-1-benzofuran-5-carbaldehyde 5-Benzofurancarboxaldehyde, 2,3-dihydro-(6CI,9CI) 2,3-Dihydro-5-benzofurancarbox 2,3-dihyro-1-benzofuran-5-carb 2,3-Dihydrobenzo[b]furan-5-carbaldehyde, 95+% 2,3-Dihydro-5-benzofurancarbaldehyde | [EINECS(EC#)]
259-788-1 | [Molecular Formula]
C9H8O2 | [MDL Number]
MFCD00068058 | [Molecular Weight]
148.16 | [MOL File]
55745-70-5.mol |
Chemical Properties | Back Directory | [Melting point ]
191~193℃ | [Boiling point ]
88-89 °C/0.1 mmHg (lit.) | [density ]
1.177 g/mL at 25 °C(lit.)
| [refractive index ]
n20/D 1.6000(lit.)
| [Fp ]
>230 °F
| [storage temp. ]
2-8°C(protect from light) | [form ]
clear liquid | [color ]
Colorless to Light orange to Yellow | [Detection Methods]
GC | [CAS DataBase Reference]
55745-70-5(CAS DataBase Reference) |
Safety Data | Back Directory | [Hazard Codes ]
Xi | [Risk Statements ]
R43:May cause sensitization by skin contact. | [Safety Statements ]
S37/39:Wear suitable gloves and eye/face protection . | [WGK Germany ]
3
| [Hazard Note ]
Irritant | [HazardClass ]
IRRITANT | [HS Code ]
29329990 |
Raw materials And Preparation Products | Back Directory | [Raw materials]
Sodium hydroxide-->Ethyl acetate-->Diethyl ether-->Tetrahydrofuran-->N,N-Dimethylformamide-->PETROLEUM ETHER-->Phosphorus oxychloride-->Magnesium sulfate-->n-Butyllithium-->Hexane-->1,2-Dibromoethane-->2,3-Dihydrobenzofuran-->2-Bromophenol | [Preparation Products]
1,2,6,7-Tetrahydro-8H-indeno[5,4-b]furan-8-one-->2,3-DIHYDRO-1-BENZOFURAN-5-YLMETHANOL-->2,6,7,8-Tetrahydro-1H-indeno[5,4-b]furan-8-ylethylamine-->2,3-Dihydro-1-benzofuran-5-propanoic acid |
Hazard Information | Back Directory | [Chemical Properties]
White to light yellow liquid | [Uses]
Hair dye composition. | [Synthesis]
2,3-Dihydrobenzofuran-5-carbaldehyde was synthesized as follows: in a dry reaction flask, 2,3-dihydrobenzofuran (100 g, 0.833 mol) was dissolved in N,N-dimethylformamide (355.0 ml). Under stirring, phosphorus oxychloride (255.58 g, 1.666 mol) was slowly added dropwise, and the reaction temperature was controlled to be maintained between 80°C and 85°C. The reaction mixture was stirred continuously at this temperature for 4 to 5 hours, during which the progress of the reaction was monitored by high performance liquid chromatography (HPLC). Upon completion of the reaction, the mixture was carefully poured into ice water to quench the reaction. Subsequently, the organic layer was separated by extraction with toluene (2000 ml). The organic layer was washed sequentially with 5% sodium bicarbonate solution (500 ml) and 10% brine solution (500 ml) to remove residual acid and DMF.The washed organic layer was subjected to distillation under reduced pressure at 50 °C to 60 °C to remove the solvent to give the crude product. By further purification, 2,3-dihydrobenzofuran-5-carbaldehyde was obtained in 85% to 90% yield and 90% to 92% purity. | [References]
[1] Patent: EP1792899, 2007, A1. Location in patent: Page/Page column 11 [2] Patent: WO2010/41271, 2010, A2. Location in patent: Page/Page column 28 [3] Letters in Drug Design and Discovery, 2013, vol. 10, # 7, p. 561 - 571 [4] Patent: CN102766135, 2017, B. Location in patent: Paragraph 0035-0036 [5] Journal of Medicinal Chemistry, 2002, vol. 45, # 19, p. 4222 - 4239 |
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