| Identification | More | [Name]
Methylprednisolone acetate | [CAS]
53-36-1 | [Synonyms]
1,4-PREGNADIEN-6-ALPHA-METHYL-11-BETA, 17,21-TRIOL-3,20-DIONE 21-ACETATE
1,4-PREGNADIEN-6-ALPHA-METHYL-17,21-DIOL-3,11,20-TRIONE ACETATE
6-ALPHA-METHYLPREDNISOLONE ACETATE
6-ALPHA-METHYLPREDNISONE ACETATE
6-METHYL PREDNISOLONE ACETATE
depo-medrate
MEDROL ACETATE
methylprednisolone 21-acetate
METHYLPREDNISOLONE ACETATE
11-beta)-h
4-diene-3,20-dione,11-beta,17,21-trihydroxy-6-alpha-methyl-pregna-21-aceta
4-diene-3,20-dione,21-(acetyloxy)-11,17-dihydroxy-6-methyl-pregna-(6-alp
depo-medrone
depo-methylprednisolone
depo-methylprednisoloneacetate
depot-medrol
u8210
urbasoncrystalsuspension
Methylprednisolone Acetate BP/USP/EP
6-alpha-methylprednisolone21-acetate | [EINECS(EC#)]
200-171-3 | [Molecular Formula]
C24H32O6 | [MDL Number]
MFCD00144786 | [Molecular Weight]
416.51 | [MOL File]
53-36-1.mol |
| Chemical Properties | Back Directory | [Appearance]
Off-White Solid | [Melting point ]
192-195°C | [alpha ]
D20 +101° (dioxane) | [Boiling point ]
454.82°C (rough estimate) | [density ]
1.1156 (rough estimate) | [refractive index ]
1.4593 (estimate) | [storage temp. ]
Refrigerator | [solubility ]
Practically insoluble in water, sparingly soluble in acetone and in ethanol (96 per cent). | [form ]
neat | [pka]
12.41±0.70(Predicted) | [color ]
White to Off-White | [optical activity]
[α]/D 85 to 105°, c =0.5 in chloroform-d | [Usage]
Glucocorticoid | [InChIKey]
PLBHSZGDDKCEHR-OJNHZLOINA-N | [SMILES]
[C@@]12([H])C[C@@H](C3=CC(=O)C=C[C@]3(C)[C@@]1([H])[C@H](C[C@]1(C)[C@@](CC[C@@]21[H])(O)C(=O)COC(=O)C)O)C |&1:0,3,10,12,14,16,18,21,r| | [CAS DataBase Reference]
53-36-1(CAS DataBase Reference) |
| Hazard Information | Back Directory | [Chemical Properties]
Off-White Solid | [Uses]
Methylprednisolone acetate is used as a glucocorticoid.
| [Definition]
ChEBI: An acetate ester resulting from the formal condensation of the 21-hydroxy function of 6alpha-methylprednisolone compound with acetic acid. | [Brand name]
Medrol (Pharmacia & Upjohn). | [Biological Activity]
Long-acting anti-inflammatory corticosteroid th at suppresses lymphocytes-mediated immunologic responses.
Methylprednisolone acetate (Depo-Medrol) is a long-acting anti-inflammatory corticosteroid th at suppresses lymphocytes-mediated immunologic responses. 6-Methylprednisolone acetate binds to intracellular glucocorticoid receptors and inhibits promoter domains of pro-inflammatory genes and hinders secretion of inflammatory cytokines. It effectively treats multiple ailments such as rheumatic and autoimmune diseases, leukemia, multiple myeloma, and Hodgkin's and non-Hodgkin's lymphoma symptoms along with other drugs. MPA improves COVID-19 pneumonia prognosis. | [Toxics Screening Level]
The initial threshold screening level (ITSL) for methylpredisolone acetate is 43 μg/m3 based on an annual averaging time. |
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