| Identification | More | [Name]
CYCLOOCTANONE | [CAS]
502-49-8 | [Synonyms]
CYCLOOCTAN-1-ONE
CYCLOOCTANONE
TIMTEC-BB SBB008888
Cyclooctanone,97%
Azelaone | [EINECS(EC#)]
207-940-2 | [Molecular Formula]
C8H14O | [MDL Number]
MFCD00001754 | [Molecular Weight]
126.2 | [MOL File]
502-49-8.mol |
| Chemical Properties | Back Directory | [Appearance]
colorless to white crystalline low melting solid | [Melting point ]
32-41 °C (lit.) | [Boiling point ]
195-197 °C (lit.) | [density ]
0.958 g/mL at 25 °C(lit.)
| [refractive index ]
1.4694 | [Fp ]
163 °F
| [storage temp. ]
Sealed in dry,Room Temperature | [solubility ]
15g/l | [form ]
Crystalline Low Melting Solid | [color ]
Colorless to white | [PH]
7 (15g/l, H2O, 20℃) | [Water Solubility ]
Soluble in water at 20°C 15g/L. Soluble in acetone, alcohol, chloroform, methanol and benzene. | [Detection Methods]
GC | [BRN ]
1280738 | [InChIKey]
IIRFCWANHMSDCG-UHFFFAOYSA-N | [LogP]
2.11 | [CAS DataBase Reference]
502-49-8(CAS DataBase Reference) | [EPA Substance Registry System]
502-49-8(EPA Substance) |
| Safety Data | Back Directory | [Hazard Codes ]
C | [Risk Statements ]
R34:Causes burns. | [Safety Statements ]
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection .
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice . | [RIDADR ]
1759 | [WGK Germany ]
3
| [RTECS ]
GX9800000
| [TSCA ]
Yes | [HazardClass ]
8 | [HS Code ]
29142990 |
| Hazard Information | Back Directory | [Chemical Properties]
colorless to white crystalline low melting solid | [Uses]
Cyclooctanone is a aliphatic cycle that exhibited inhibitory activity towards aldosterone synthase, a promising therapeutic target for the treatment of cardiovascular diseases related to abnormally high aldosterone level. | [Synthesis Reference(s)]
Journal of the American Chemical Society, 92, p. 5276, 1970 DOI: 10.1021/ja00720a078
The Journal of Organic Chemistry, 49, p. 3912, 1984 DOI: 10.1021/jo00195a007
Tetrahedron Letters, 36, p. 2921, 1995 DOI: 10.1016/0040-4039(95)00467-Q | [Purification Methods]
Purify the ketone by sublimation after drying with Linde type 13X molecular sieves. The semicarbazone has m 168-169o (from dioxane) [Kohler et al. J Am Chem Soc 61 1060 1939]. The oxime has m 36-37o after subliming at high vacuum or distillation and has b 128-129o /14mm. The iso-oxime has m 72-73o [Ruzicka et al. Helv Chim Acta 32 548 1949]. [Beilstein 7 III 77, 7 IV 49.] |
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