| Identification | More | [Name]
3,5-Dimethoxyphenol | [CAS]
500-99-2 | [Synonyms]
3,5-DIMETHOXYPHENOL
PHLOROGLUCINOL DIMETHYL ETHER
1-Hydroxy-3,5-dimethoxybenzene
Taxicatigenin
3,5-Dimethoxy Phenol, 98%min
3,5-DIMETHYOXY PHENYL HYDROXIDE
Phenol, 3,5-dimethoxy-
Phloroglucin dimethyl ether | [EINECS(EC#)]
207-917-7 | [Molecular Formula]
C8H10O3 | [MDL Number]
MFCD00008388 | [Molecular Weight]
154.16 | [MOL File]
500-99-2.mol |
| Chemical Properties | Back Directory | [Appearance]
slightly pink to yellow crystalline powder | [Melting point ]
40-43 °C (lit.) | [Boiling point ]
172-175 °C/17 mmHg (lit.) | [density ]
1.1690 (rough estimate) | [refractive index ]
1.4745 (estimate) | [Fp ]
173 °F
| [storage temp. ]
Store in dark! | [solubility ]
Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly) | [form ]
Liquid | [pka]
pK1:9.345 (25°C) | [color ]
Clear colorless to orange-red to pale pink-brownish | [Water Solubility ]
Soluble in methanol, ethanol, benzene, water (slightly), and chloroform. | [Sensitive ]
Air & Light Sensitive | [BRN ]
1239156 | [InChIKey]
XQDNFAMOIPNVES-UHFFFAOYSA-N | [LogP]
1.640 | [CAS DataBase Reference]
500-99-2(CAS DataBase Reference) | [NIST Chemistry Reference]
Phenol, 3,5-dimethoxy-(500-99-2) | [EPA Substance Registry System]
500-99-2(EPA Substance) |
| Safety Data | Back Directory | [Hazard Codes ]
Xi | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36:Wear suitable protective clothing .
S37/39:Wear suitable gloves and eye/face protection . | [WGK Germany ]
3
| [F ]
10 | [Hazard Note ]
Irritant | [HS Code ]
29095000 |
| Hazard Information | Back Directory | [Chemical Properties]
slightly pink to yellow crystalline powder | [Uses]
3,5-dimethoxyphenol is a marker for poisoning from Taxus baccata. | [Uses]
3,5-Dimethoxyphenol is a phenol derivative as antinitrosating agent. | [Definition]
ChEBI: 3,5-Dimethoxyphenol is a member of methoxybenzenes and a member of phenols. | [Synthesis]
Ethanethiol (1.25g, 1.5 ml, 0.02 mole) dissolved in N, N- dimethyl-formamide (20 ml) is added to a suspension of sodium hydride (1 g of 50%oil dispersion) in dry DMF (10 ml) under an atmosphere of nitrogen. The mixture is stirred for 5 min under anhydrous conditions. A solution of phloroglucinol trimethyl ether (1.14) (1 g,0.006 moles) in dry DMF (10 ml)is added, and the mixture is refluxed for 3 hr. The reaction mixture is cooled and acidified with hydrochloric acid (10%). It is extracted with ether(3 x 50 ml). The ether extract is washed with water and extracted with sodium hydroxide solution (5%). The clear alkaline extract is acidified with hydrochloric acid. The mixture is extracted with ether. The ether extract is washed with water, ried (anhydrous sodium sulphate), and drilled. 3,5-Dimethoxyphenol is obtained as an oil. Yield 0.9 g (98.1%).B.p.198-199°/30 mm.
 | [Purification Methods]
Purify the phenol by distillation followed by sublimation in a vacuum. [Beilstein 6 IV 7362.] |
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