| Identification | More | [Name]
7-Chloro-2-methylquinoline | [CAS]
4965-33-7 | [Synonyms]
2-METHYL-7-CHLOROQUINOLINE
7-CHLORO-2-METHYLQUINOLINE
7-CHLOROQUINALDINE
Chloroquinaldine,98%
Montelukast7-ChloroQuinaldine
7-ChloroQuinaldine98.5%
7ChloroQuinaldineMontelukast
7-CHLOROQUINALDINE 99%
7-Chloroquinaldine ,99% | [EINECS(EC#)]
440-600-3 | [Molecular Formula]
C10H8ClN | [MDL Number]
MFCD00075436 | [Molecular Weight]
177.63 | [MOL File]
4965-33-7.mol |
| Chemical Properties | Back Directory | [Appearance]
white to light yellow crystal powder | [Melting point ]
74-78 °C (lit.) | [Boiling point ]
87 °C / 0.5mmHg | [density ]
1.1810 (rough estimate) | [refractive index ]
1.6000 (estimate) | [storage temp. ]
Sealed in dry,Room Temperature | [solubility ]
Chloroform (Slightly), Methanol (Slightly) | [form ]
Solid | [pka]
4.25±0.50(Predicted) | [color ]
Pale Yellow to Light Beige | [Detection Methods]
HPLC,NMR | [BRN ]
115318 | [InChI]
InChI=1S/C10H8ClN/c1-7-2-3-8-4-5-9(11)6-10(8)12-7/h2-6H,1H3 | [InChIKey]
WQZQFYRSYLXBGP-UHFFFAOYSA-N | [SMILES]
N1C2C(=CC=C(Cl)C=2)C=CC=1C | [CAS DataBase Reference]
4965-33-7(CAS DataBase Reference) | [NIST Chemistry Reference]
Quinoline, 7-chloro-2-methyl-(4965-33-7) |
| Safety Data | Back Directory | [Hazard Codes ]
Xi | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36:Wear suitable protective clothing . | [WGK Germany ]
3
| [HazardClass ]
IRRITANT | [HS Code ]
29334900 |
| Hazard Information | Back Directory | [Chemical Properties]
white to light yellow crystal powder | [Uses]
7-Chloroquinaldine is used as the starting material in the synthesis of (E)-1-[3-[2-(7-Chloro-2-quinolinyl)ethenyl]phenyl]-2-propen-1-ol (C381415); an intermediate in the synthesis of the antiasthmatic, Montelukast Sodium Salt (M568000). | [Synthesis]
To a 50 mL round-bottomed flask equipped with a condenser and a PTFE stirrer was added m-chloroaniline (1 mmol), acetonitrile (5 mL), Catalyst 1 (10 mol%), and vinyl ether (3 mmol). The reaction mixture was heated in air at 80 °C for the reaction time referred to Table 1. The progress of the reaction was monitored by thin layer chromatography (TLC). Upon completion of the reaction, the solvent was removed by distillation under reduced pressure and the residue was purified by silica gel column chromatography (eluent: hexane/ethyl acetate) to afford 7-chloro-2-methylquinoline. The structure of the product was confirmed by comparing the spectral data reported in the literature. | [References]
[1] Tetrahedron Letters, 2014, vol. 55, # 15, p. 2406 - 2409 |
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