| Identification | More | [Name]
3-ETHOXYSALICYLALDEHYDE | [CAS]
492-88-6 | [Synonyms]
2-HYDROXY-3-ETHOXYBENZALDEHYDE
3-ETHOXY-2-HYDROXYBENZALDEHYDE
3-ETHOXYSALICYLALDEHYDE
AKOS BBS-00003146
O-ETHYLVANILLIN
TIMTEC-BB SBB008590
3-ethoxy-2-hydroxy-benzaldehyd
3-Ethoxy-2-hydroxybenzaldehye
Novovanillin
Salicylaldehyde, 3-ethoxy-
Ethoxysalicylaldehyde
o-Ethylvanilline
ORTHO-ETHYLVANILLIN | [EINECS(EC#)]
207-765-1 | [Molecular Formula]
C9H10O3 | [MDL Number]
MFCD00003323 | [Molecular Weight]
166.17 | [MOL File]
492-88-6.mol |
| Chemical Properties | Back Directory | [Melting point ]
66-68 °C (lit.) | [Boiling point ]
263-264 °C (lit.) | [density ]
1.1097 (rough estimate) | [refractive index ]
1.4500 (estimate) | [Fp ]
263-264°C | [storage temp. ]
under inert gas (nitrogen or Argon) at 2-8°C | [form ]
powder to crystal | [pka]
8.30±0.10(Predicted) | [color ]
Light yellow to Brown to Dark green | [Water Solubility ]
Soluble in cold water. Insoluble in methanol, ethanol, acetone and acetonitrile | [Sensitive ]
Air Sensitive | [InChI]
InChI=1S/C9H10O3/c1-2-12-8-5-3-4-7(6-10)9(8)11/h3-6,11H,2H2,1H3 | [InChIKey]
OFQBYHLLIJGMNP-UHFFFAOYSA-N | [SMILES]
C(=O)C1=CC=CC(OCC)=C1O | [CAS DataBase Reference]
492-88-6(CAS DataBase Reference) | [EPA Substance Registry System]
Benzaldehyde, 3-ethoxy-2-hydroxy- (492-88-6) |
| Safety Data | Back Directory | [Hazard Codes ]
Xi | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36:Wear suitable protective clothing . | [WGK Germany ]
3
| [RTECS ]
CU6123000
| [TSCA ]
Yes | [HS Code ]
29124990 | [Toxicity]
LD50 ipr-mus: 360 mg/kg COREAF 238,2576,54 |
| Hazard Information | Back Directory | [Description]
3-ethoxysalicylaldehyde is also known as o-ethyl vanillin. 3-ethoxysalicylaldehyde often appears as a by-product in the production process of ethyl vanillin, which gradually becomes an alternative to vanillin since it possesses a flavor and odor approximately 3 ～ 4 times as intense as vanillin. In recent years, it has been discovered that 3-ethoxysalicylaldehyde possesses potential applications in optical utilization, biology, catalysis, and corrosion inhibition. Moreover, 3-ethoxysalicyaldehyde has been applied in various medicinal applications[1]. | [Uses]
3-Ethoxysalicylaldehyde was used in the preparation of:
- Schiff base ligand via condensation with trans-1,2-diaminocyclohexane
- substituted salen-type Schiff base ligands
- a new Schiff base, 2-ethoxy-6-[(3-methylaminopropylimino)methyl]phenol, via reaction with N-methylpropane-1,3-diamine
| [Safety Profile]
A poison by intraperitoneal andintravenous routes. When heated to decomposition itemits acrid smoke and irritating vapors. | [References]
[1] Haifang Mao . “Solubility measurement and data correlation of 3-ethoxysalicylaldehyde in twelve pure solvents at temperatures from 278.15 to 313.15 K.” Journal of Chemical Thermodynamics 188 (2023): Article 107162.
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