| Identification | More | [Name]
Ethylmethyl-carbamic chloride | [CAS]
42252-34-6 | [Synonyms]
CARBAMIC CHLORIDE, ETHYLMETHYL-
Ethylmethyl-carbamic chloride
N-ETHYL-N-METHYLCARBAMONYL CHLORIDE
n-ethyl-n-methylcarbamoyl chloride
N,N-ETHYLMETHYL CARBAMOYL CHLORIDE
Rivastigmine Intermediate 1
ETHYLMETHYLCARBAMOYL CHLORIDE
cis-2-(2-benzylcarboxylamido-4-thiazolyl)-4-(3-methyl-2-butyleneoxycarboxyl)-2-butenoicacid | [EINECS(EC#)]
610-003-4 | [Molecular Formula]
C4H8ClNO | [MDL Number]
MFCD08061404 | [Molecular Weight]
121.57 | [MOL File]
42252-34-6.mol |
| Chemical Properties | Back Directory | [Boiling point ]
89°C/40mmHg(lit.) | [density ]
1.101±0.06 g/cm3(Predicted) | [refractive index ]
1.4500-1.4540 | [storage temp. ]
Inert atmosphere,2-8°C | [solubility ]
Chloroform (Sparingly), Ethyl Acetate (Slightly) | [form ]
clear liquid | [pka]
-1.85±0.70(Predicted) | [color ]
Colorless to Almost colorless | [Stability:]
Hygroscopic | [InChI]
InChI=1S/C4H8ClNO/c1-3-6(2)4(5)7/h3H2,1-2H3 | [InChIKey]
XZVYDRLPXWFRIS-UHFFFAOYSA-N | [SMILES]
C(Cl)(=O)N(CC)C | [CAS DataBase Reference]
42252-34-6(CAS DataBase Reference) |
| Hazard Information | Back Directory | [Chemical Properties]
Pale Yellow Oil | [Synthesis]
Example 1: A solution of N-ethylmethylamine (100 g, 1.69 mol) in dichloromethane (1.5 L) was slowly added dropwise to a suspension in dichloromethane (2 L) containing sodium bicarbonate (284 g, 3.384 mol) and triphosgene (332 g, 1.117 mol), the temperature was maintained at a controlled level of 10-15°C, and the dropwise process lasted for 2 hours. After completion of the dropwise addition, the reaction mixture was continued to be stirred at room temperature for 3 hours. Upon completion of the reaction, the resulting sodium chloride was removed by filtration and the filtrate was concentrated under reduced pressure to afford 189 g of N-methyl-N-ethylcarbamoyl chloride, the product being a light yellow oil (yield: 92%). Example 3: The procedure of Example 2 was repeated, only the solvent was changed to methylene chloride, and the rest of the reaction conditions remained unchanged. The experimental results are shown in Table 2, the yield consistently exceeded 98%. | [References]
[1] Patent: WO2007/80430, 2007, A1. Location in patent: Page/Page column 12; 13
[2] Research on Chemical Intermediates, 2014, vol. 40, # 2, p. 787 - 800
[3] Patent: WO2013/150529, 2013, A2. Location in patent: Page/Page column 24; 25; 28; 29
[4] Patent: WO2007/80430, 2007, A1. Location in patent: Page/Page column 13
[5] Patent: WO2007/80430, 2007, A1. Location in patent: Page/Page column 13 |
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