| Identification | More | [Name]
Trifluoroacetic anhydride | [CAS]
407-25-0 | [Synonyms]
BIS(TRIFLUOROACETIC) ANHYDRIDE
TFA
TFAA
TRIFLUORACETIC ANHYDRIDE
TRIFLUOROACETIC ACID ANHYDRIDE
TRIFLUOROACETIC ANHYDRIDE
Aceticacid,trifluoro-,anhydride
Anhydrid kyseliny trifluoroctove
anhydridkyselinytrifluoroctove
Hexafluoroacetic anhydride
hexafluoroaceticanhydride
Perfluoroacetic anhydride
perfluoroaceticanhydride
trifluoroacetic
trifluoro-aceticacianhydride
Trifluoroacetyl anhydride
trifluoroacetylanhydride
Trifluoroethanoicanhydride
Triflyuoroacetic anhydride
TRIFLUOROACETIC ANHYDRIDE, REAGENTPLUS, >=99% | [EINECS(EC#)]
206-982-9 | [Molecular Formula]
C4F6O3 | [MDL Number]
MFCD00000416 | [Molecular Weight]
210.03 | [MOL File]
407-25-0.mol |
| Chemical Properties | Back Directory | [Appearance]
Clear, colorless liquid | [Melting point ]
-65 °C (lit.) | [Boiling point ]
39.5-40 °C (lit.) | [density ]
1.511 g/mL at 20 °C(lit.)
| [vapor pressure ]
6.28 psi ( 20 °C)
| [refractive index ]
n20/D 1.3(lit.)
| [Fp ]
-26 °C | [storage temp. ]
2-8°C
| [solubility ]
Miscible with benzene, dichloromethane, diethyl ether, dimethylformamide, terahydrofuran and acetonitrile. | [form ]
Liquid | [pka]
0.43[at 20 ℃] | [color ]
Clear | [Specific Gravity]
1.487 | [Stability:]
Stable, but moisture sensitive. Reacts with water to liberate hydrogen (flammable!). Incompatible with water, strong oxidizing agents. | [Water Solubility ]
Hydrolysis | [Sensitive ]
Moisture Sensitive | [BRN ]
746197 | [LogP]
0.79 at 25℃ | [CAS DataBase Reference]
407-25-0(CAS DataBase Reference) | [NIST Chemistry Reference]
Acetic acid, trifluoro-, anhydride(407-25-0) | [Storage Precautions]
Moisture sensitive | [EPA Substance Registry System]
407-25-0(EPA Substance) |
| Safety Data | Back Directory | [Hazard Codes ]
C,T | [Risk Statements ]
R14:Reacts violently with water.
R20:Harmful by inhalation.
R35:Causes severe burns.
R52/53:Harmful to aquatic organisms, may cause long-term adverse effects in the aquatic environment .
R34:Causes burns.
R23/24/25:Toxic by inhalation, in contact with skin and if swallowed . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection .
S43:In case of fire, use ... (indicate in the space the precise type of fire-fighting equipment. If water increases the risk add-Never use water) .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) .
S61:Avoid release to the environment. Refer to special instructions safety data sheet .
S9:Keep container in a well-ventilated place .
S8:Keep container dry .
S27:Take off immediately all contaminated clothing . | [RIDADR ]
UN 3265 8/PG 1
| [WGK Germany ]
2
| [RTECS ]
AJ9800000
| [F ]
3-10 | [Hazard Note ]
Corrosive/Moisture Sensitive | [TSCA ]
T | [HazardClass ]
8 | [PackingGroup ]
I | [HS Code ]
29159080 | [Toxicity]
skn-rbt 500 mg/24H SEV 28ZPAK -,91,72 |
| Hazard Information | Back Directory | [Description]
Trifluoroacetic acid anhydride (TFAA), a perfluoroacylated acylation reagent, forms stable, volatile derivatives with alcohols, amines, and phenols. | [Chemical Properties]
Clear, colorless liquid | [Uses]
Used as analytical reagents, solvents, catalysts, dehydration condensing agent, protection agent of trifluoroacetylation of carboxyl and amino; used as Intermediate of fluorine fine chemicals, pharmaceutical, agrochemical. | [Preparation]
Trifluoroacetic anhydride is prepared by reaction of trifluoroacetyl chloride with an alkali metal or alkaline-earth metal salt of trifluoroacetic acid at approximately 50° C. | [reaction suitability]
reagent type: derivatization reagent
reaction type: Acylations
reagent type: derivatization reagent
reaction type: Esterifications | [Safety Profile]
A severe skin and eye irritant.Explosive reaction with dimethyl sulfoxide; nitric acid +1,3,5-triazine (at 36°C); nitric acid + 1,3,5-triacetylhexahydro-1,3,5-triazine (at 30°C). Incompatiblewith lithium tetrahydroaluminate. When heated todecomposit | [Purification Methods]
Purification by distilling over KMnO4, as for the acid above, is EXTREMELY DANGEROUS due to the possiblility of EXPLOSION. It is best purified by distilling from P2O5 slowly, and collecting the fraction boiling at 39.5o. Store it in a dry atmosphere. Highly TOXIC vapour and attacks skin, work in an efficient fume hood. [Beilstein 2 IV 469.] |
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