| Identification | More | [Name]
Methyl 2-amino-4-methylthiazole-5-carboxylate | [CAS]
3829-80-9 | [Synonyms]
2-AMINO-4-METHYL-THIAZOLE-5-CARBOXYLIC ACID METHYL ESTER
AKOS B000344
ART-CHEM-BB B000344
BUTTPARK 76\07-67
CHEMBRDG-BB 4142897
METHYL 2-AMINO-4-METHYL-1,3-THIAZOLE-5-CARBOXYLATE
METHYL 2-AMINO-4-METHYLTHIAZOLE-5-CARBOXYLATE
OTAVA-BB BB7216516553
SALOR-INT L481033-1EA
SPECS AG-670/25010006
TIMTEC-BB SBB000179
2-Amino-4-methylthiazole-5-methyl formate
Methyl 2-amino-4-methylthiazole-5-
Methyl 2-amino-4-methyl-5-thiazolecarboxylate | [EINECS(EC#)]
672-079-5 | [Molecular Formula]
C6H8N2O2S | [MDL Number]
MFCD01993690 | [Molecular Weight]
172.2 | [MOL File]
3829-80-9.mol |
| Chemical Properties | Back Directory | [Appearance]
white crysta | [Melting point ]
171-174 °C | [Boiling point ]
301.3±22.0 °C(Predicted) | [density ]
1.339±0.06 g/cm3(Predicted) | [storage temp. ]
2-8°C, protect from light | [form ]
solid | [pka]
3.83±0.10(Predicted) | [color ]
Yellow | [InChI]
InChI=1S/C6H8N2O2S/c1-3-4(5(9)10-2)11-6(7)8-3/h1-2H3,(H2,7,8) | [InChIKey]
TYUGYIMCRDPMPJ-UHFFFAOYSA-N | [SMILES]
S1C(C(OC)=O)=C(C)N=C1N | [CAS DataBase Reference]
3829-80-9(CAS DataBase Reference) |
| Hazard Information | Back Directory | [Chemical Properties]
white crysta | [Synthesis]
GENERAL METHODS: A mixture of methyl acetoacetate (0.5 mmol), thiourea (0.5 mmol), iodine (0.5 mmol), DMSO (2 mL), and MMT-K10 (20 mg) was reacted at 80 °C with stirring. The reaction progress was monitored by TLC (unfolding agent: petroleum ether/ethyl acetate, 4:1). Upon completion of the reaction, the catalyst was separated by filtration and the solvent was subsequently removed under reduced pressure. The crude product was dissolved in hot water and extracted with ether (3 x 30 mL), and the pH of the aqueous phase was adjusted to 9-10 with ammonia to precipitate the solid product. Finally, the resulting precipitate was recrystallized from ethanol to give methyl 2-amino-4-methylthiazole-5-carboxylate. | [References]
[1] RSC Advances, 2016, vol. 6, # 69, p. 64749 - 64755
[2] Research on Chemical Intermediates, 2016, vol. 42, # 12, p. 8175 - 8183
[3] Advanced Synthesis and Catalysis, 2018, vol. 360, # 8, p. 1584 - 1589
[4] Monatshefte fur Chemie, 2017, vol. 148, # 4, p. 745 - 749
[5] Journal of Molecular Structure, 2017, vol. 1144, p. 58 - 65 |
|
|