| Identification | More | [Name]
1-ISOPROPYL-1H-1,2,3-BENZOTRIAZOLE-5-CARBOXYLIC ACID | [CAS]
306935-41-1 | [Synonyms]
IBC 293
IPBT-5CA
BUTTPARK 36\04-50
1-ISOPROPYLBENZOTRIAZOLE-5-CARBOXYLIC ACID
1-propan-2-ylbenzotriazole-5-carboxylic acid
1-propan-2-yl-5-benzotriazolecarboxylic acid
1-ISOPROPYL-1H-BENZOTRIAZOLE-5-CARBOXYLIC ACID
1-Isopropyl-1,2,3-benzotriazole-5-carboxylic acid
1-(1-METHYLETHYL)-1H-BENZOTRIAZOLE-5-CARBOXYLIC ACID
1-ISOPROPYL-1H-1,2,3-BENZOTRIAZOLE-5-CARBOXYLIC ACID
1H-Benzotriazole-5-carboxylic acid, 1-(1-methylethyl)-
1-ISOPROPYL-1H-BENZO[D][1,2,3]TRIAZOLE-5-CARBOXYLIC ACID
1-(Prop-2-yl)-1H-benzotriazole-5-carboxylic acid, 5-Carboxy-1-isopropyl-1H-benzotriazole | [Molecular Formula]
C10H11N3O2 | [MDL Number]
MFCD01570664 | [Molecular Weight]
205.21 | [MOL File]
306935-41-1.mol |
| Chemical Properties | Back Directory | [Melting point ]
229-230°C | [Boiling point ]
413.9±18.0 °C(Predicted) | [density ]
1.37±0.1 g/cm3(Predicted) | [storage temp. ]
Store at RT | [solubility ]
Soluble in DMSO (up to 25 mg/ml). | [form ]
Light brown solid | [pka]
3.50±0.30(Predicted) | [color ]
Off-white | [Stability:]
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months. | [CAS DataBase Reference]
306935-41-1(CAS DataBase Reference) |
| Safety Data | Back Directory | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection . | [Hazard Note ]
Irritant | [HS Code ]
2933998090 |
| Hazard Information | Back Directory | [Description]
IPBT-5CA (306935-41-1) is a highly selective agonist for the human orphan G-protein-coupled receptor GPR109b (EC50 = 400 nM). No activity was reported at the highly homologous high-affinity niacin receptor GPR109a. | [Definition]
ChEBI: 1-propan-2-yl-5-benzotriazolecarboxylic acid is a member of benzotriazoles. | [Biological Activity]
Highly selective agonist for GPR109B (HM74), the human orphan G-protein-coupled receptor expressed in adipocytes. Selective for GPR109B over closely related niacin receptor GPR109A (HM74A); EC 50 values are 400 nM and > 1 μ M respectively. In vitro, inhibits isoproterenol-stimulated lipolysis in isolated human adipocytes.牋 | [References]
1) Semple et al. (2006) 1-Alkyl-benzotriazole-5-carboxylic acids are highly selective agonists of the human orphan G-protein-coupled receptor GPR109b; J. Med. Chem., 49 1227 |
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Shanghai Uchem Inc.
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15618758386 15618758386 |
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