| Identification | More | [Name]
SPERMINE TETRAHYDROCHLORIDE | [CAS]
306-67-2 | [Synonyms]
1,4-BIS(AMINOPROPYL)BUTANEDIAMINE TETRAHYDROCHLORIDE
DIAMINOPROPYLTETRAMETHYLENEDIAMINE HYDROCHLORIDE
GERONTINE TETRAHYDROCHLORIDE
MUSCULAMINE HYDROCHLORIDE
MUSCULAMINE TETRAHYDROCHLORIDE
NEURIDINE HYDROCHLORIDE
NEURIDINE TETRAHYDROCHLORIDE
N,N'-BIS(3-AMINOPROPYL)-1,4-BUTANEDIAMINE 4 H CL
N,N'-BIS(3-AMINOPROPYL)-1,4-BUTANEDIAMINE TETRAHYDROCHLORIDE
N,N'-BIS-(3-AMINOPROPYL)-1,4-DIAMINOBUTANE TETRAHYDROCHLORIDE
N,N'-BIS(3-AMINOPROPYL)-BUTANE-1,4-DIAMINE TETRAHYDROCHLORIDE
SPERMINE HYDROCHLORIDE
SPERMINE TETRAHYDROCHLORIDE
1,4-Butanediamine,N,N’-bis(3-aminopropyl)-,tetrahydrochloride
4-butanediamine,n,n’-bis(3-aminopropyl)-tetrahydrochloride
4,9-diazoniadodecamethylenediammonium tetrachloride
Spermine, TetraHCl
SPERMINE TETRAHYDROCHLORIDE MOLECULAR*BI OLOGY REAGE
SPERMINE TETRAHYDROCHLORIDE, F. MOLE-CUL AR BIOLOGY
Spermine tetrahydrochloride 0.1 M Solution | [EINECS(EC#)]
206-189-8 | [Molecular Formula]
C10H30Cl4N4 | [MDL Number]
MFCD00012914 | [Molecular Weight]
348.18 | [MOL File]
306-67-2.mol |
| Chemical Properties | Back Directory | [Melting point ]
310-311 °C (dec.)(lit.)
| [density ]
1.01 g/mL at 20 °C | [storage temp. ]
2-8°C
| [solubility ]
H2O: 1 M at 20 °C, clear, colorless
| [form ]
powder
| [color ]
White to Almost white | [PH]
4.5-7.0 (25℃, 1M in H2O) | [biological source]
synthetic | [Water Solubility ]
Soluble in water (348.2 g/L at 20°C). | [λmax]
λ: 260 nm Amax: 0.2
λ: 280 nm Amax: 0.15 | [BRN ]
3911771 | [InChI]
InChI=1S/C10H26N4.4ClH/c11-5-3-9-13-7-1-2-8-14-10-4-6-12;;;;/h13-14H,1-12H2;4*1H | [InChIKey]
XLDKUDAXZWHPFH-UHFFFAOYSA-N | [SMILES]
C(CNCCCN)CCNCCCN.Cl.Cl.Cl.Cl | [CAS DataBase Reference]
306-67-2(CAS DataBase Reference) | [EPA Substance Registry System]
Spermine tetrahydrochloride (306-67-2) |
| Safety Data | Back Directory | [Hazard Codes ]
Xi | [Risk Statements ]
R36/38:Irritating to eyes and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36:Wear suitable protective clothing . | [WGK Germany ]
3
| [RTECS ]
EJ7230000
| [F ]
3-10 | [TSCA ]
Yes | [HS Code ]
29212900 |
| Hazard Information | Back Directory | [Chemical Properties]
White to off-white powder | [Uses]
Spermine tetrahydrochloride was used to precipitate DNA for flow cytometric analysis from fresh frozen breast cancer tissue, archival tissue of salivary gland, renal and thyroid tumors and red blood cells of chicken. | [Uses]
Used to precipitate DNA from low salt aqueous buffers. | [Uses]
Spermine Tetrahydrochloride is an inhibitor of NOS1, NMDA, GluR, and PLCα. A useful reactant for Surface-?enhanced Raman spectroscopy (SERS) characterization of abasic sites in DNA duplexes. | [General Description]
This certified reference material (CRM) is produced and certified in accordance with ISO/IEC 17025 and ISO 17034. This CRM is traceable to primary material from an NMI, e.g. NIST or NMIJ.
Certified content by quantitative NMR incl. uncertainty and expiry date are given on the certificate.
Download your certificate at: http://www.sigma-aldrich.com. | [Biological Activity]
Polyamine which produces a variety of modulatory effects on the NMDA receptor channel, acting through a specific site on the complex which can cause both agonist and antagonist effects. | [Biochem/physiol Actions]
Mixed NMDA agonist/antagonist at the polyamine site. Neuroprotective effects have been observed at high concentrations (1 mM), while neurotoxicity is observed at lower concentrations. It enhances agonist effectiveness at the strychnine-insensitive glycine site. Plays a role in cellular proliferation and differentiation; inhibits neuronal nitric oxide synthase (nNOS). | [storage]
Store at RT | [Purification Methods]
Its pK values are similar to those of spermidine above. Purify it as for spermidine trihydrochloride above. [Beilstein 4 IV 1301.] |
|
|