| Identification | More | [Name]
4-HYDROXYMETHYL-5-METHYLIMIDAZOLE | [CAS]
29636-87-1 | [Synonyms]
4-Methyl-5-imidazolemethanol
Cimetidine Impurity I HCl(EP)
4-Hydoxymethyl-5-methylimidazol
5-methyl-1h-imidazole-4-methano
5-methyl-1H-imidazole-4-methanol
4-Methyl-1H-imidazole-5-methanol
5-Hydroxymethyl-4-methylimidazole
5-METHYL-4-HYDROXYMETHYLIMIDAZOLE
4-HYDROXYMETHYL-5-METHYLIMIDAZOLE
1H-Imidazole-5-methanol, 4-methyl-
(4-Methyl-1H-imidazol-5-yl)methanol
4-Hydroxymethyl-5-methylimidazole>
(5-METHYL-1H-IMIDAZOL-4-YL)-METHANOL
4-Methyl-5-hydroxymethyl-1H-imidazole
4-hydroxymethyl-5-methylimidazole base
4-(Hydroxymethyl)-5-methyl-1H-imidazole
4-Methyl-5-(hydroxymethyl)-1H-imidazole
Cimetidine Impurity 15（Cimetidine EP Impurity I） | [EINECS(EC#)]
249-740-8 | [Molecular Formula]
C5H8N2O | [MDL Number]
MFCD00792476 | [Molecular Weight]
112.13 | [MOL File]
29636-87-1.mol |
| Chemical Properties | Back Directory | [Melting point ]
136°C | [Boiling point ]
389.1±27.0 °C(Predicted) | [density ]
1.231 | [storage temp. ]
Sealed in dry,2-8°C | [solubility ]
DMSO (Heated), Methanol (Slightly) | [form ]
Solid | [pka]
13.62±0.10(Predicted) | [color ]
White to Off-White | [Water Solubility ]
almost transparency | [InChI]
InChI=1S/C5H8N2O/c1-4-5(2-8)7-3-6-4/h3,8H,2H2,1H3,(H,6,7) | [InChIKey]
AXJZCJSXNZZMDU-UHFFFAOYSA-N | [SMILES]
C1NC(CO)=C(C)N=1 | [LogP]
-0.62 at 23℃ and pH8.4 | [CAS DataBase Reference]
29636-87-1(CAS DataBase Reference) | [EPA Substance Registry System]
1H-Imidazole-4-methanol, 5-methyl- (29636-87-1) |
| Safety Data | Back Directory | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection . | [HS Code ]
2933299090 |
| Hazard Information | Back Directory | [Uses]
4-Hydroxymethyl-5-methylimidazole is used as an intermediate of Alosetron hydrochloride, a 5-HT3 antagonist used only for the treatment of irritable bowel syndrome (IBS) in women with predominantly severe diarrhoea. As the drug causes ischaemic colitis, a life-threatening condition in which intestinal tissue dies due to lack of blood flow to the colon. Therefore, it is no longer used. |
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