| Identification | More | [Name]
DL-Dithiothreitol | [CAS]
27565-41-9 | [Synonyms]
1,4-DITHIO-DL-THREITOL
1,4-DITHIOTHREITHOL
1,4-DITHIOTHREITOL
2,3-BUTANEDIOL, 1,4-DIMERCAPTO-(R*,R*)-
(2S,3S:2R,3R)-THREO-1,4-DIMERCAPTO-2,3-BUTANEDIOL
CGMP DTT
CLELAND REAGENT RACEMIC
CLELANDS REAGENT
CLELAND'S REAGENT
CLELAND'S REAGENT, IMMOBILIZED
CLELAND'S REDUCTACRYL(TM) REAGENT
(+/-)-DITHIOTHREITOL
DITHIOTHREITOL
DITHIOTHREITOL, 1,4-
DITHIOTHRIETOL
DITT
DL-1,4-DIMERCAPTO-2,3-BUTANEDIOL
DL-1,4-DITHIOTHREITOL
DL-2,3-DIHYDROXY-1,4-BUTANEDITHIOL
DL-DITHIOTHREITOL | [EINECS(EC#)]
222-468-7 | [Molecular Formula]
C4H10O2S2 | [MDL Number]
MFCD00004877 | [Molecular Weight]
154.25 | [MOL File]
27565-41-9.mol |
| Safety Data | Back Directory | [Hazard Codes ]
Xn | [Risk Statements ]
R25:Toxic if swallowed.
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) . | [WGK Germany ]
3
| [RTECS ]
EK1610000
| [F ]
3-10-16-23 | [HS Code ]
29309090 | [Toxicity]
mouse,LD50,intramuscular,108mg/kg (108mg/kg),BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD,Journal of Pharmacy and Pharmacology. Vol. 1, Pg. 576, 1949. |
| Hazard Information | Back Directory | [Chemical Properties]
White solid | [Uses]
Reagent for the quantitative reduction of disulfide group. Prevents the oxidation of cholecystokinin during its extraction from brain and duodenal tissues. Cleavage of disulfide bonds in proteins. | [Definition]
ChEBI: D-1,4-dithiothreitol is a 1,4-dithiothreitol. It is an enantiomer of a L-1,4-dithiothreitol. | [Preparation]
The preparation of DL-Dithiothreitol is as follows:To a round bottom flask was charged THPP (23mg, 0.11mmol, 1.10eq) and the basic buffer solution [tris-(hydroxymethyl)-aminomethane-CaCl2 based buffer; pH 8.00; 1.0mL]. The reaction mixture was stirred at room temperature for about 5 min and then to this homogenous solution was charged trans-4,5-Dihydroxy-1,2-dithiane (15.2mg, 0.10 mmol, 1.00eq.). The reaction mixture was stirred at room temperature until the reaction was complete (about 30 min). The product was readily identified by 1H-NMR analysis. | [Purification Methods]
Crystallise DTT from ether and sublime it at 37o/0.005mm. It should be stored at 0o. [Beilstein 1 III 2360.] |
|
|