| Identification | More | [Name]
trans-4-Aminocyclohexanol | [CAS]
27489-62-9 | [Synonyms]
AMINOCYCLOHEXANOL(TRANS-4)
AURORA KA-7506
TIMTEC-BB SBB005825
TRANS-4-AMINO-1-HYDROXYCYCLOHEXANE
trans-4-aminocyclohexan-1-ol
4-Trans amino cyclohexanol
trans-4-Aminocyclohexanol, 98+%
trans-4-hydroxycyclohexylamine
trans-4-Aminocyclohexanol 97%
Trans-4-Aminocyclohexanol ( For Ambroxol Hcl )
Cyclohexanol, 4-amino-, trans-
(1α)-4β-Aminocyclohexanol | [EINECS(EC#)]
248-492-8 | [Molecular Formula]
C6H13NO | [MDL Number]
MFCD00067698 | [Molecular Weight]
115.17 | [MOL File]
27489-62-9.mol |
| Chemical Properties | Back Directory | [Appearance]
white to light yellow crystal powder | [Melting point ]
108-113°C | [Boiling point ]
127 °C / 14mmHg | [density ]
0.9837 (rough estimate) | [refractive index ]
1.4713 (estimate) | [storage temp. ]
Keep in dark place,Inert atmosphere,Room temperature | [solubility ]
Chloroform (Slightly), Methanol (Slightly) | [form ]
Crystals | [pka]
15.12±0.40(Predicted) | [color ]
White to almost white | [Water Solubility ]
Soluble in water. | [Sensitive ]
Hygroscopic | [LogP]
-0.4 | [CAS DataBase Reference]
27489-62-9(CAS DataBase Reference) |
| Safety Data | Back Directory | [Hazard Codes ]
Xi,C | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin .
R34:Causes burns. | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S37/39:Wear suitable gloves and eye/face protection .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection . | [RIDADR ]
3259 | [Hazard Note ]
Irritant | [HazardClass ]
8 | [HazardClass ]
IRRITANT | [PackingGroup ]
Ⅲ | [HS Code ]
29221990 |
| Questions And Answer | Back Directory | [Description]
Trans-4-Aminocyclohexanol is also named as Cis-4-Aminocyclohexanol. It was a medical intermediate of ambroxol, which is used in the treatment of respiratory diseases associated with viscid or excessive mucus.1 It is used as a raw material in organic synthesis, such as in the synthesis of N-substituted 7-azabicyclo [2.2.1] hepatanes, which are good substrates for microbial oxidation of unactivated carbons by B.bassiana.2
| [Reference]
- Y. Jian, Improved Process of the Synthesis of Trans-4-aminocyclohexanol, Fine Chemicals, 2000, vol. 2
- H. F. Olivo, M. S. Hemenway, M. H. Gezginci, Synthesis and Microbial Hydroxylation of Some Azabicycloalkanes, Tetrahedron Letters, 1998, vol. 39, pp. 1309-1312
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